Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
The journal of nutrition, health & aging
Published in: The journal of nutrition, health & aging 10/2018

01-12-2018 | Editorial

Bidirectional Communication Between Brain and Muscle

Author: John E. Morley

Published in: The journal of nutrition, health & aging | Issue 10/2018

Login to get access

Excerpt

Communication between the brain and muscle plays a key role in maintaining the function of an individual. A classical example of this failure to communicate is after a stroke which leads to a failure of the brain to communicate with the periphery resulting in the muscle becoming flaccid. With aging there is a gradual decline in the communication between the central nervous system and skeletal muscle. This leads to a decrease in speed of movement, weakness, an increased tendency to fall and eventually a decline in function. …
Literature
1.
Carson RG. Get a grip: Individual variations in grip strength are a marker of brain health. Neurobiol Aging 2018;71:189–222.CrossRefPubMed
2.
3.
Chu YH, Tang PF, Peng YC, Chen HY. Meta-analysis of type and complexity of a secondary task during walking on the prediction of elderly falls. Geriatr Gerontol Int 2013;13:289–297.CrossRefPubMed
4.
Manini TM, Hong SL, Clark BC. Aging and muscle: A neuron’s perspective. Curr Opin Clin Nutr Metab Care 2013 January; 16(1). Doi:10.1097/MCO.0b013e32835b5880.
5.
MacDonald SW, Karlsson S, Rieckmann A, et al. Aging-related increases in behavioral variability: Relations to losses of dopamine D1 receptors. J Neurosci 2012;32:8186–8191.CrossRefPubMedPubMedCentral
6.
Drey M, Grosch C, Neuwirth C, et al. The motor unit number index (MUNIX) in sarcopenic patients. Exp Gerontol 2013;48:381–384.CrossRefPubMed
7.
Kandel ER, Schwartz JH, Fessell TM, et al. Principles of Neural Science. 5. McGraw-Hill Companies, Inc; 2012.
8.
Firth J, Stubbs B, Vancampfort D, et al. Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. Neuroimage 2018;166:230–238.CrossRefPubMed
9.
Smith JC, Nielson KA, Antuono P, et al. Semantic memory functional MRI and cognitive function after exercise intervention in mild cognitive impairment. J Alzheimers Dis 2013;37:197–215.CrossRefPubMedPubMedCentral
10.
Loprinzi PD, Blough J, Ryu S, Kang M. Experimental effects of exercise on memory function among mild cognitive impairment: Systematic review and meta-analysis. Phys Sportsmed 2018;Sep 22. Doi:10.1080/00913847.2018.1527647 [Epub ahead of print].
11.
Du Z, Li Y, Li J, et al. Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials. Clin Interv Aging 2018;13:1593–1603.CrossRefPubMedPubMedCentral
12.
Auyeung TW, Lee JS, Kwok T, Woo J. Physical frailty predicts future cognitive decline–a four-year prospective study in 2737 cognitively normal older adults. J Nutr Health Aging 2011;15:690–694.CrossRefPubMed
13.
Miyawaki CE, Bouldin ED, Kumar GS, McGuire LC. Associations between physical activity and cognitive functioning among middle-aged and older adults. J Nutr Health Aging 2017;21:637–647.CrossRefPubMedPubMedCentral
14.
Guerrieri D, oon HY, van Praag H. Exercise in a pill: The latest on exercise-mimetics. Brain Plasticity 2 (2016/2017) 153–169.
15.
Alkadhi KA. Exercise as a positive modulator of brain function. Mol Neurobiol 2018;55:3112–3130.CrossRef
16.
Delezie J, Handschin C. Endocrine crosstalk between skeletal muscle and the brain. Front Neurol 2018 Aug 24 doi.org/10.3389/fneur.2018.00798.
17.
Son JS, Chae SA, Testroet ED, et al. Exercise-induced myokines: A brief review of controversial issues of this decade. Expert Rev Endocrinol Metab 2018;13:51–58.CrossRefPubMed
18.
Grygiel-Gorniak B, Puszczewicz M. A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity. Eur Rev Med Pharmacol Sci 2017;21:4687–4693.PubMed
19.
Kaluzna M, Hoppe K, Schwermer K, et al. Preanalytical, analytical, and postanalytical errors in the measurement of irisin levels. Authors’ reply. Pol Arch Intern Med 2017;127(9):643–644.CrossRefPubMed
20.
Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans–results from a randomized controlled training trial. BMC Med 2013 Nov 5;11:235. Doi:10.1186/1741-715-11-235.CrossRefPubMedPubMedCentral
21.
Taylor JL, Amann M, Duchateau J, et al. Neural contributions to muscle fatigue: From the brain to the muscle and back again. Med Sci Sports Exerc 2016 Nov;48(11):2294–2306.CrossRefPubMedPubMedCentral
22.
Cervenka I, Agudelo LZ, Ruas JL. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. Science 2017 Jul 28;357(6349). Doi:10.1126/science.aaf9794.
23.
Shortz AE, Pickens A, Zheng Q, Mehta RK. The effect of cognitive fatigue on prefrontal cortex correlates of neuromuscular fatigue in older women. J NeuroEngineering and Rehab 2015;12:115. Doi:10.1186/s12984-015-0108-3CrossRef
24.
Cordeiro LMS, Rabelo PCR, Moraes MM, et al. Physical exercise-induced fatigue: The role of serotonergic and dopaminergic systems. Braz J Med Biol Res 2017;50:e6432. Doi: 10.1590/1414-431X2017643.CrossRefPubMedPubMedCentral
25.
Schuch FB, Vancampfort D, Firth J, et al. Physical activity and incident depression: A meta-analysis of prospective cohort studies. A, J Psychiatry 2018;175:631–648.CrossRef
26.
Malmstrom TK, Morley JE. Frailty and cognition: Linking two common syndromes in older persons. J Nutr Health Aging 2013;17:723–725.CrossRefPubMed
27.
Kelaiditi E, Cesari M, Canevelli M, et al. Cognitive frailty: Rational and definition from an I.A.N.A./I.A.G.G.) international consensus group. J Nutr Health Aging 2013;17:726–734.CrossRef
28.
Yu R, Morley JE, Kwok T, et al. The effects of combinations of cognitive impairment and pre-frailty on adverse outcomes from a prospective community-based cohort study of older Chinese people. Front Med (Lausanne) 2018 Mar 6;5:50. DOI: 10.3389/fmed.2018.00050. eCollectionCrossRef
29.
Morley JE, Morris JC, Berg-Weger M, et al. Brain health: The importance of recognizing cognitive impairment: An IAGG consensus conference. J Am Med Dir Assoc 2015;16:731–739.CrossRefPubMedPubMedCentral
30.
Canevelli M, Cesari M. Cognitive frailty: What is still missing? J Nutr Health Aging 2015;19:273–275.CrossRefPubMed
31.
Morley JE. White matter lesions (leukoaraiosis): A major cause of falls. J Am Med Dir Assoc 2015;16:441–443.CrossRefPubMed
32.
Pantoni L, Fierini F, Poggesi A; LADIS Study Group. Impact of cerebral white matter changes on functionality in older adults: An overview of the LADIS study results and future directions. Geriatr Gerontol Int 2015;15(Suppl 10:10–16.CrossRefPubMed
33.
Pantoni L, Poggesi A, Inzitari D. The relation between white-matter lesions and cognition. Curr Opin Neurol 2007 Aug;20(4):390–397.CrossRefPubMed
34.
Chode S, Malmstrom TK, Miller DK, Morley JE. Frailty, diabetes, and mortality in middle-aged African Americans. J Nutr Health Aging 2016;20:854–859.CrossRefPubMed
35.
Banks WA, Farr SA, Morley JE. Entry of blood-borne cytokines into the central nervous system: Effects on cognitive processes. Neuroimmunomodulation 2002-2003;10:319–327.CrossRef
36.
Allali G, Ayers EI, Verghese J. Motoric cognitive risk syndrome subtypes and cognitive profiles. J Gerontol A Biol Sci Med Sci 2016;71:378–384.CrossRefPubMed
Metadata
Title
Bidirectional Communication Between Brain and Muscle
Author
John E. Morley
Publication date
01-12-2018
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 10/2018
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-018-1141-2

Other articles of this Issue 10/2018

The journal of nutrition, health & aging 10/2018 Go to the issue

OriginalPaper

Pre Frail 80: Multifactorial Intervention to Prevent Progression of Pre-Frailty to Frailty in the Elderly

OriginalPaper

Measuring Sarcopenia Severity in Older Adults and the Value of Effective Interventions

OriginalPaper

EuroQol Visual Analogue Scale (EQ-VAS) as a Predicting Tool for Frailty in Older Korean Adults: The Korean Frailty and Aging Cohort Study (KFACS)

OriginalPaper

Dietary Ingestion of Calories and Micronutrients Modulates the DNA Methylation Profile of Leukocytes from Older Individuals

OriginalPaper

Nutrition, Daily Walking and Resilience are Associated with Physical Function in the Oldest Old Men

Editorial

Resilience
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits