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Open Access 01-12-2009 | Research article

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure

Authors: Alfredo José Mansur, Rosana Seleri Fontes, Regina Airoldi Canzi, Raphael Nishimura, Airlane Pereira Alencar, Antonio Carlos Pedroso de Lima, José Eduardo Krieger, Alexandre Costa Pereira

Published in: BMC Cardiovascular Disorders | Issue 1/2009

Abstract

Background -

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure. We evaluated these polymorphisms relative to clinical characteristics and prognosis of alarge cohort of patients with heart failure of different etiologies.

Methods -

We studied 501 patients with heart failure of different etiologies. Mean age was 58 years (standard deviation 14.4 years), 298 (60%) were men. Polymorphisms were identified by polymerase chain reaction-restriction fragment length polymorphism.

Results -

During the mean follow-up of 12.6 months (standard deviation 10.3 months), 188 (38%) patients died. Distribution of genotypes of polymorphism Arg16Gly was different relative to body mass index (χ² = 9.797;p = 0.04). Overall the probability of survival was not significantly predicted by genotypes of Gln27Glu, Arg16Gly, or Thr164Ile. Allele and haplotype analysis also did not disclose any significant difference regarding mortality. Exploratory analysis through classification trees pointed towards a potential association between the Gln27Glu polymorphism and mortality in older individuals.

Conclusion -

In this study sample, we were not able to demonstrate an overall influence of polymorphisms Gln27Glu and Arg16Gly of beta-2 receptor gene on prognosis. Nevertheless, Gln27Glu polymorphism may have a potential predictive value in older individuals.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/9/50/prepub

Title: Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure
Authors: Alfredo José Mansur
Rosana Seleri Fontes
Regina Airoldi Canzi
Raphael Nishimura
Airlane Pereira Alencar
Antonio Carlos Pedroso de Lima
José Eduardo Krieger
Alexandre Costa Pereira
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2009
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/1471-2261-9-50

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure

Abstract

Background -

Methods -

Results -

Conclusion -

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background -

Methods -

Results -

Conclusion -

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