Published in:
01-02-2004 | Poster presentation
Benzisothiazole derivative inhibits toll-like receptor 4 signal transduction and prevents mice from the lethal shock
Authors:
Y Hosaka, Y Shimizu, M Nakamura, Y Sato, Y Miyazaki, T Sato, M Mizuno, Y Kato, S Furusako
Published in:
Critical Care
|
Special Issue 1/2004
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Excerpt
Sepsis is a syndrome, a consequence of an overwhelming systemic response to infection. It rapidly leads to organ dysfunction, which accompanies systemic inflammation and hematological abnormalities. In Gram-negative bacteria, lipopolysaccharide (LPS) has a dominant role for the activation of various cells, which secrete several proinflammatory cytokines including TNF-α. These cytokines are also important in inducing a procoagulant effect in sepsis. On the other hand, toll-like receptor 4 (TLR4) is responsible for the LPS signaling and causes the activation of NF-κB. It is clear that an inappropriate TLR response to bacterial infection could have critical consequences. Therefore, TLR4 signal inhibitor is attractive as a therapeutic medication for sepsis. …
