Skip to main content
Top
Published in: Behavioral and Brain Functions 1/2019

Open Access 01-12-2019 | Review

Behavioral models in psychopathology: epistemic and semantic considerations

Authors: Caio Maximino, Franz Josef van der Staay

Published in: Behavioral and Brain Functions | Issue 1/2019

Login to get access

Abstract

The use of animals in neurosciences has a long history. It is considered indispensable in areas in which “translational” research is deemed invaluable, such as behavioral pharmacology and comparative psychology. Animal models are being used in pharmacology and genetics to screen for treatment targets, and in the field of experimental psychopathology to understand the neurobehavioral underpinnings of a disorder and of its putative treatment. The centrality of behavioral models betrays the complexity of the epistemic and semantic considerations which are needed to understand what a model is. In this review, such considerations are made, and the breadth of model building and evaluation approaches is extended to include theoretical considerations on the etiology of mental disorders. This expansion is expected to help improve the validity of behavioral models and to increase their translational value. Moreover, the role of theory in improving construct validity creates the need for behavioral scientists to fully engage this process.
Footnotes
1
There are many different senses of the term “model” that can bring confusion. For example, the diathesis-stress theory is normally called “diathesis-stress model”, and “model” here has a very different meaning—that of a theoretical model. In an attempt to dispel the confusion, we reserve the term “model” to refer to behavioral models.
 
Literature
5.
go back to reference Baird D. Thing knowledge: a philosophy of scientific instruments. Berkeley: University of California Press; 2004. Baird D. Thing knowledge: a philosophy of scientific instruments. Berkeley: University of California Press; 2004.
6.
go back to reference Bakshi VP, Kalin NH. Animal models and endophenotypes of anxiety and stress disorders. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology. The fifth generation of progress. New York: American College of Neuropsychopharmacology; 2002. p. 883–900. Bakshi VP, Kalin NH. Animal models and endophenotypes of anxiety and stress disorders. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology. The fifth generation of progress. New York: American College of Neuropsychopharmacology; 2002. p. 883–900.
11.
go back to reference Braff DL, Freedman R. Endophenotypes in studies of the genetics of schizophrenia. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology. The fifth generation of progress. New York: American College of Neuropsychopharmacology; 2002. p. 703–16. Braff DL, Freedman R. Endophenotypes in studies of the genetics of schizophrenia. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology. The fifth generation of progress. New York: American College of Neuropsychopharmacology; 2002. p. 703–16.
12.
go back to reference Brunner D, Nestler E, Leahy E. In need of high-throughput behavioral systems. Drug Discov Today. 2002;7:107–12.CrossRef Brunner D, Nestler E, Leahy E. In need of high-throughput behavioral systems. Drug Discov Today. 2002;7:107–12.CrossRef
15.
go back to reference Cairncross KD, Cox B, Forster C, Wren AF. A new model for the detection of antidepressant drugs: Olfactory bulbectomy in the rat compared with existing models. J Pharmacol Methods. 1978;1:131–43.CrossRef Cairncross KD, Cox B, Forster C, Wren AF. A new model for the detection of antidepressant drugs: Olfactory bulbectomy in the rat compared with existing models. J Pharmacol Methods. 1978;1:131–43.CrossRef
16.
go back to reference Cassano GB, Rossi NB, Pini S. Comorbidity of depression and anxiety. In: Kasper S, den Boer JA, Ad Sitsen JM, editors. Handbook of depression and anxiety: second edition, revised and expanded (Segunda, pp. 69–90). Nova Iorque: Marcel Dekker, Inc.; 2003. p. 69–90. Cassano GB, Rossi NB, Pini S. Comorbidity of depression and anxiety. In: Kasper S, den Boer JA, Ad Sitsen JM, editors. Handbook of depression and anxiety: second edition, revised and expanded (Segunda, pp. 69–90). Nova Iorque: Marcel Dekker, Inc.; 2003. p. 69–90.
24.
go back to reference Einat H, Belmaker RH, Manji HK. New approaches to modeling bipolar disorder. Psychopharmacol Bull. 2003;37:47–63.PubMed Einat H, Belmaker RH, Manji HK. New approaches to modeling bipolar disorder. Psychopharmacol Bull. 2003;37:47–63.PubMed
28.
go back to reference Frigg R. Scientific representation and the semantic view of theories. Theoria. 2006;55:37–53. Frigg R. Scientific representation and the semantic view of theories. Theoria. 2006;55:37–53.
30.
go back to reference Gerlai R. High-throughput behavioral screens: The first step towards finding genes involved in vertebratebrain function using zebrafish. Molecules. 2010;15:2609–22.CrossRef Gerlai R. High-throughput behavioral screens: The first step towards finding genes involved in vertebratebrain function using zebrafish. Molecules. 2010;15:2609–22.CrossRef
31.
go back to reference Geyer MA, Markou A. The role of preclinical models in the development of psychotropic drugs. In: Davis KL, Charney DS, Coyle JT, Nemeroff CB, editors. Neuropsychopharmacology. The fifth generation of progress. 5th ed. New York: Raven Press/American College of Neuropsychopharmacology; 2002. p. 445–55. Geyer MA, Markou A. The role of preclinical models in the development of psychotropic drugs. In: Davis KL, Charney DS, Coyle JT, Nemeroff CB, editors. Neuropsychopharmacology. The fifth generation of progress. 5th ed. New York: Raven Press/American College of Neuropsychopharmacology; 2002. p. 445–55.
32.
go back to reference Glas G. A conceptual history of anxiety and depression. In: Kasper S, den Boer JA, Ad Sitsen JM, editors. Handbook of depression and anxiety: second edition, revised and expanded (Segunda ed, pp. 1–47). Nova Iorque: Marcel Dekker, Inc.; 2003. Glas G. A conceptual history of anxiety and depression. In: Kasper S, den Boer JA, Ad Sitsen JM, editors. Handbook of depression and anxiety: second edition, revised and expanded (Segunda ed, pp. 1–47). Nova Iorque: Marcel Dekker, Inc.; 2003.
33.
go back to reference Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–45.CrossRef Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–45.CrossRef
35.
go back to reference Gouveia A Jr, de Brito TM. Animal models of psychopathology and its relation to clinical practice. In: Gargiulo PÁ, Mesones-Arroyo HL, editors. Psychiatry and neuroscience update. Bridging the divide. New York: Springer; 2015. p. 305–9.CrossRef Gouveia A Jr, de Brito TM. Animal models of psychopathology and its relation to clinical practice. In: Gargiulo PÁ, Mesones-Arroyo HL, editors. Psychiatry and neuroscience update. Bridging the divide. New York: Springer; 2015. p. 305–9.CrossRef
36.
go back to reference Hau J. Animal models. In: Hau J, van Hoosier GL, editors. Handbook of laboratory animal science, vol. 2. 2nd ed. Boca Raton: CRC Press; 2003. p. 1–9. Hau J. Animal models. In: Hau J, van Hoosier GL, editors. Handbook of laboratory animal science, vol. 2. 2nd ed. Boca Raton: CRC Press; 2003. p. 1–9.
37.
go back to reference Hesse M. Models and analogies in science. London: Sheed and Ward; 1963. Hesse M. Models and analogies in science. London: Sheed and Ward; 1963.
38.
go back to reference Ingram RE, Luxton DD. Vulnerability-stress models. In: Hankin BL, Abela JRZ, editors. Development of psychopathology: a vulnerability stress perspective. Thousand Oaks: Sage Publications Inc; 2005. p. 32–46.CrossRef Ingram RE, Luxton DD. Vulnerability-stress models. In: Hankin BL, Abela JRZ, editors. Development of psychopathology: a vulnerability stress perspective. Thousand Oaks: Sage Publications Inc; 2005. p. 32–46.CrossRef
46.
go back to reference LaFollette H, Shanks N. Two models of models in biomedical research. Philos Q. 1995;45:141–60.CrossRef LaFollette H, Shanks N. Two models of models in biomedical research. Philos Q. 1995;45:141–60.CrossRef
49.
go back to reference Lipp HP. High-throughput and automated behavioural screening of normal and genetically modified mice. Bus Brief Future Drug Discov. 2005:1–5. Lipp HP. High-throughput and automated behavioural screening of normal and genetically modified mice. Bus Brief Future Drug Discov. 2005:1–5.
53.
go back to reference Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, et al. Stress-induced hyperthermiaand anxiety: Pharmacological validation. Eur J Pharmacol. 2003;463:117–32.CrossRef Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, et al. Stress-induced hyperthermiaand anxiety: Pharmacological validation. Eur J Pharmacol. 2003;463:117–32.CrossRef
56.
go back to reference Rodgers RJ, Cao B-J, Dalvi A, Holmes A. Animal models of anxiety: an ethological perspective. Braz J Med Biol Res. 1997;30:289–304.CrossRef Rodgers RJ, Cao B-J, Dalvi A, Holmes A. Animal models of anxiety: an ethological perspective. Braz J Med Biol Res. 1997;30:289–304.CrossRef
60.
go back to reference Schaffner KF. Extrapolation from animal models: social life, sex and super models. In: Machamer PK, Grush R, McLaughlin P, editors. Theory and method in the neurosciences. Pittsburgh: University of Pittsburgh Press; 2001. p. 200–30. Schaffner KF. Extrapolation from animal models: social life, sex and super models. In: Machamer PK, Grush R, McLaughlin P, editors. Theory and method in the neurosciences. Pittsburgh: University of Pittsburgh Press; 2001. p. 200–30.
61.
go back to reference Schaefer AT, Claridge-Chang A. The surveillance state of behavioral automation. Curr Opin Neurobiol. 2012;22:170–6.CrossRef Schaefer AT, Claridge-Chang A. The surveillance state of behavioral automation. Curr Opin Neurobiol. 2012;22:170–6.CrossRef
62.
go back to reference Shapiro KJ. Animal models of human psychology: critique of science, ethics, and policy. Seattle: Hogrefe & Huber; 1998. Shapiro KJ. Animal models of human psychology: critique of science, ethics, and policy. Seattle: Hogrefe & Huber; 1998.
67.
go back to reference Tecott LH, Nestler EJ. Neurobehavioral assessment in the information age. Nat Neurosci. 2004;7:462–6.CrossRef Tecott LH, Nestler EJ. Neurobehavioral assessment in the information age. Nat Neurosci. 2004;7:462–6.CrossRef
69.
go back to reference van de Weerd HA, Bulthuis RJA, Bergman AF, Schlingmann F, Tolboom J, van Loo PLP, et al. Validation ofa new system for the automatic registration of behaviour in mice and rats. Behav Processes. 2001;53:11–20.CrossRef van de Weerd HA, Bulthuis RJA, Bergman AF, Schlingmann F, Tolboom J, van Loo PLP, et al. Validation ofa new system for the automatic registration of behaviour in mice and rats. Behav Processes. 2001;53:11–20.CrossRef
74.
go back to reference van der Staay FK, Nordquist RE, Arndt SS. Large farm animal models of human neurobehavioral and psychiatric disorders: methodological and practical considerations. In: Conn PM, editor. Animal models for the study of human disease. 2nd ed. Cambridge: Academic Press; 2017. p. 71–100.CrossRef van der Staay FK, Nordquist RE, Arndt SS. Large farm animal models of human neurobehavioral and psychiatric disorders: methodological and practical considerations. In: Conn PM, editor. Animal models for the study of human disease. 2nd ed. Cambridge: Academic Press; 2017. p. 71–100.CrossRef
75.
go back to reference Wall PM, Messier C. Methodological and conceptual issues in the use of the elevated plus-maze as a psychological measurement instrument of animal anxiety-like behavior. Neurosci Biobehav Rev. 2001;25:275–86.CrossRef Wall PM, Messier C. Methodological and conceptual issues in the use of the elevated plus-maze as a psychological measurement instrument of animal anxiety-like behavior. Neurosci Biobehav Rev. 2001;25:275–86.CrossRef
78.
go back to reference Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatry. 1986;10:677–90.CrossRef Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatry. 1986;10:677–90.CrossRef
79.
go back to reference Willner P. Methods for assessing the validity of animal models of human psychopathology. In: Boulton AA, Baker GB, Martin-Iverson MT, editors. Animal models in psychiatry. Clifton: Humana Press; 1991. p. 1–23. Willner P. Methods for assessing the validity of animal models of human psychopathology. In: Boulton AA, Baker GB, Martin-Iverson MT, editors. Animal models in psychiatry. Clifton: Humana Press; 1991. p. 1–23.
Metadata
Title
Behavioral models in psychopathology: epistemic and semantic considerations
Authors
Caio Maximino
Franz Josef van der Staay
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2019
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-019-0152-4

Other articles of this Issue 1/2019

Behavioral and Brain Functions 1/2019 Go to the issue