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16-02-2024 | Bariatric Surgery | Original Contributions

Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance

Authors: Jessica M. V. Pino, Vitória F. Silva, Raquel M. S. Campos, Marcos Mônico-Neto, Kaique A. de Araujo, Danielle C. Seva, Melissa Y. Kato, Thales D. Galvão, Lia R. A. Bitterncourt, Sergio Tufik, Kil S. Lee

Published in: Obesity Surgery | Issue 4/2024

Abstract

Introduction

Bariatric surgery is an effective intervention to reduce obesity and improve associated comorbidities. However, its effects on cognitive function are still the subject of debate. Given that the bioavailability of circulating metabolites can influence brain metabolism and cognitive performance, we aimed to assess the effects of bariatric surgery on plasma metabolic profiles and cognitive performance.

Methods

We recruited 26 women undergoing gastric bypass surgery. We conducted anthropometric assessments and collected plasma samples for metabolomic analysis. A set of 4 cognitive tests were used to evaluate cognitive performance. Participants were reevaluated 1 year post-surgery.

Results

After surgery, attention capacity and executive function were improved, while immediate memory had deteriorated. Regarding metabolic profile, reduction of beta-tocopherol and increase of serine, glutamic acid, butanoic acid, and glycolic acid were observed. To better understand the relationship between cognitive function and metabolites, a cluster analysis was conducted to identify more homogeneous subgroups based on the cognitive performance. We identified cluster 1, which did not show changes in cognitive performance after surgery, and cluster 2, which showed improved attention and executive function, but reduced performance in the immediate memory test. Thus, cluster 2 was more homogeneous group that replicated the results of non-clustered subjects. Analysis of the metabolic profile of cluster 2 confirmed serine, glutamic acid, and glycolic acid as potential metabolites associated with cognitive performance.

Conclusions

Metabolites identified in this study have potential for biomarkers and alternative therapeutic target to prevent obesity-related cognitive decline.

Key points

• Attention capacity and executive function were improved 12 months post bariatric surgery.

• Immediate memory was worsened 12 months post bariatric surgery.

• Serine, glutamic acid, and glycolic acid are potential metabolites linked to the alteration of cognitive performance.

Graphical Abstract

Available only for authorised users

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Title: Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance
Authors: Jessica M. V. Pino
Vitória F. Silva
Raquel M. S. Campos
Marcos Mônico-Neto
Kaique A. de Araujo
Danielle C. Seva
Melissa Y. Kato
Thales D. Galvão
Lia R. A. Bitterncourt
Sergio Tufik
Kil S. Lee
Publication date: 16-02-2024
Publisher: Springer US
Keywords: Bariatric Surgery
Bariatric Surgery
Obesity
Obesity
Published in: Obesity Surgery / Issue 4/2024
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-024-07096-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance

Abstract

Introduction

Methods

Results

Conclusions

Key points

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

Key points

Graphical Abstract

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