Skip to main content
Top
Published in: Rheumatology International 1/2006

01-11-2006 | Original Article

Balneotherapy and tap water therapy in the treatment of knee osteoarthritis

Authors: Merih Yurtkuran, Mustafa Yurtkuran, Alev Alp, Aşkın Nasırcılar, Ümit Bingöl, Lale Altan, Gülnazik Sarpdere

Published in: Rheumatology International | Issue 1/2006

Login to get access

Abstract

To investigate if spa water is superior to tap water (TW) in relieving the symptoms of pain, joint motion, life quality in knee osteoarthritis (KOA) patients. In this randomized placebo-controlled trial, 52 patients with KOA were followed in two groups. In group I (n = 27), patients were treated in the pool full of spa water at 37°C for 20 min a day, 5 days a week, for a period of 2 weeks. In group II (n = 25), the same protocol was used but spa water was replaced by TW heated to 37°C. Patients in both groups were given a home-based standardized exercise program. Evaluation parameters were pain (pVAS), tenderness score (TS), 50-ft walking duration, quadriceps muscle strength (QMS), active flexion degree (AFD), WOMAC OA index, and Nottingham Health Profile (NHP). The first evaluation was done after the informed consent was obtained. Second and third evaluations were done at the 2nd and 12th week. PVAS, 50-ft walking duration, AFD, TS, WOMAC, and NHP variables improved in group I. Same variables except QMS improved also in group II. Comparison of the groups just after treatment showed that only pVAS (P = 0.015), NHP pain score (P = 0.020), and TS (P = 0.002) differed significantly in favor of group I at the 2nd or 12th week. Both of the thermal treatment modalities were found to be effective in the management of the clinical symptoms and quality of life in KOA patients. However, pain and tenderness improved statistically better with balneotherapy. There were no significant differences between the groups for the other variables.
Literature
1.
go back to reference Pritzker K (2003) Pathology of osteoarthritis. In: Brandt K, Doherty M, Lohmander LS (eds) Osteoarthritis, 2nd edn. Oxford University Press, Oxford, pp 49–58 Pritzker K (2003) Pathology of osteoarthritis. In: Brandt K, Doherty M, Lohmander LS (eds) Osteoarthritis, 2nd edn. Oxford University Press, Oxford, pp 49–58
2.
go back to reference Jordan KM, Arden NK, Doherty M et al (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62:1145–1155PubMedCrossRef Jordan KM, Arden NK, Doherty M et al (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62:1145–1155PubMedCrossRef
3.
go back to reference Dieppe P, Lohmander S (2005) Pathogenesis and management of pain in osteoarthritis. Lancet 365:965–973PubMedCrossRef Dieppe P, Lohmander S (2005) Pathogenesis and management of pain in osteoarthritis. Lancet 365:965–973PubMedCrossRef
4.
5.
go back to reference Woof AD, Akesson K (2001) Understanding the burden of musculoskeletal conditions. The burden is huge and not reflected in national health priorities. BMJ 322:1079–1080CrossRef Woof AD, Akesson K (2001) Understanding the burden of musculoskeletal conditions. The burden is huge and not reflected in national health priorities. BMJ 322:1079–1080CrossRef
6.
go back to reference Dieppe P, Basler HD, Chard J, Croft P, Dixon J, Hurley M (1999) Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilisation. Rheumatology (Oxford) 38:73–77CrossRef Dieppe P, Basler HD, Chard J, Croft P, Dixon J, Hurley M (1999) Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilisation. Rheumatology (Oxford) 38:73–77CrossRef
7.
go back to reference American College of Rheumatology Subcommittee on Osteoarthritis Guidelines (2000) Recommendations for the medical management of osteoarthritis of the hip and knee. Arthritis Rheum 43:1905–1915 American College of Rheumatology Subcommittee on Osteoarthritis Guidelines (2000) Recommendations for the medical management of osteoarthritis of the hip and knee. Arthritis Rheum 43:1905–1915
8.
go back to reference Pendleton A, Arden N, Dougados M et al (2000) EULAR recommendations for the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 59:936–944PubMedCrossRef Pendleton A, Arden N, Dougados M et al (2000) EULAR recommendations for the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 59:936–944PubMedCrossRef
9.
go back to reference Yurtkuran M, Kocagil T (1999) TENS, electroacupuncture and ice massage: comparison of treatment for osteoarthritis of the knee. Am J Acupunct 27:133–140PubMed Yurtkuran M, Kocagil T (1999) TENS, electroacupuncture and ice massage: comparison of treatment for osteoarthritis of the knee. Am J Acupunct 27:133–140PubMed
10.
go back to reference Ay A, Yurtkuran M (2005) Influence of aquatic and weight-bearing exercises on quantitative ultrasound variables in postmenopausal women. Am J Phys Med Rehabil 84(1):52–61PubMedCrossRef Ay A, Yurtkuran M (2005) Influence of aquatic and weight-bearing exercises on quantitative ultrasound variables in postmenopausal women. Am J Phys Med Rehabil 84(1):52–61PubMedCrossRef
11.
go back to reference Sukenik S, Flusser D, Abu-Shakra (1999) The role of spa therapy in various rheumatic disease. Rheum Dis North Am 25:883–897CrossRef Sukenik S, Flusser D, Abu-Shakra (1999) The role of spa therapy in various rheumatic disease. Rheum Dis North Am 25:883–897CrossRef
12.
go back to reference Yurtkuran M, Kahraman Z, Sivriglu K, Afşin Y, Doğan M (1997) Balneotherapy in low back pain. Eur J Phys Med Rehabil 7:120–123 Yurtkuran M, Kahraman Z, Sivriglu K, Afşin Y, Doğan M (1997) Balneotherapy in low back pain. Eur J Phys Med Rehabil 7:120–123
13.
go back to reference Yurtkuran M, Yurtkuran MA, Dilek K, Güllülü M, Karakoç Y, Özbek L et al (1999) A randomized, controlled study of balneotherapy in patients with rheumatoid arthritis. Phys Rehabil Kur Med 9:92–96 Yurtkuran M, Yurtkuran MA, Dilek K, Güllülü M, Karakoç Y, Özbek L et al (1999) A randomized, controlled study of balneotherapy in patients with rheumatoid arthritis. Phys Rehabil Kur Med 9:92–96
14.
go back to reference Sukenik S, Baradin R, Codish S, Neumann L, Flusser D, Abu-Shakra M et al (2001) Balneotherapy at the Dead Sea area for patients with psoriatic arthritis and concomitant fibromyalgia. Isr Med Assoc J 3:147–150PubMed Sukenik S, Baradin R, Codish S, Neumann L, Flusser D, Abu-Shakra M et al (2001) Balneotherapy at the Dead Sea area for patients with psoriatic arthritis and concomitant fibromyalgia. Isr Med Assoc J 3:147–150PubMed
15.
go back to reference Neumann L, Sukenik S, Bolotin M, Abu-Shakra M, Amir M, Flusser D (2001) The effect of balneotherapy at the Dead Sea on the quality of life of patients with fibromyalgia syndrome. Clin Rheumatol 20:15–19PubMedCrossRef Neumann L, Sukenik S, Bolotin M, Abu-Shakra M, Amir M, Flusser D (2001) The effect of balneotherapy at the Dead Sea on the quality of life of patients with fibromyalgia syndrome. Clin Rheumatol 20:15–19PubMedCrossRef
16.
go back to reference Altan L, Bingöl U, Aykaç M, Koc Z, Yurtkuran M (2004) Investigation of the effects of pool-based exercise on fibromyalgia syndrome. Rheumatol Int 24(5):272–277PubMedCrossRef Altan L, Bingöl U, Aykaç M, Koc Z, Yurtkuran M (2004) Investigation of the effects of pool-based exercise on fibromyalgia syndrome. Rheumatol Int 24(5):272–277PubMedCrossRef
17.
go back to reference Verhagen AP, Bierma-Zeinstra SMA, Cardoso JR, de Bie RA, Boers M, de Vet HCW (2005) Balneotherapy for rheumatoid arthritis. Cochrane Database Syst Rev 1 Verhagen AP, Bierma-Zeinstra SMA, Cardoso JR, de Bie RA, Boers M, de Vet HCW (2005) Balneotherapy for rheumatoid arthritis. Cochrane Database Syst Rev 1
18.
go back to reference Elkayam O, Wigler I, Tishler M, Rosenblum I, Caspi D, Segal R (1991) Effect of spa therapy in Tiberias on patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 18:1799–1803PubMed Elkayam O, Wigler I, Tishler M, Rosenblum I, Caspi D, Segal R (1991) Effect of spa therapy in Tiberias on patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 18:1799–1803PubMed
19.
go back to reference Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long term efficacy of radon spa therapy in rheumatoid arthritis; a randomized sham-controlled study and follow-up. Rheumatology 39:894–902PubMedCrossRef Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long term efficacy of radon spa therapy in rheumatoid arthritis; a randomized sham-controlled study and follow-up. Rheumatology 39:894–902PubMedCrossRef
20.
go back to reference Lehmann JE (ed) (1990) Krusen’s handbook of physical Medicine and rehabilitation. W.B. Saunders Company, Philadelphia Lehmann JE (ed) (1990) Krusen’s handbook of physical Medicine and rehabilitation. W.B. Saunders Company, Philadelphia
21.
go back to reference Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomized controlled trial. Br J Rheumatol 36:77–81PubMedCrossRef Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomized controlled trial. Br J Rheumatol 36:77–81PubMedCrossRef
22.
go back to reference Guillemin F, Virion JM, Escudier P, De Talance N, Weryha G (2001) Effect on osteoarthritis of spa therapy at Bourbonne-les Bains. Joint Bone Spine 68:499–503PubMedCrossRef Guillemin F, Virion JM, Escudier P, De Talance N, Weryha G (2001) Effect on osteoarthritis of spa therapy at Bourbonne-les Bains. Joint Bone Spine 68:499–503PubMedCrossRef
23.
go back to reference Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Knipschild PG (2001) Balneotherapy for rheumatoid arthritis and osteoarthritis (Cochrane review). In: The Cochrane Library, Issue 1. Oxford: Update Software Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Knipschild PG (2001) Balneotherapy for rheumatoid arthritis and osteoarthritis (Cochrane review). In: The Cochrane Library, Issue 1. Oxford: Update Software
24.
go back to reference Altman RD, Blach DA, Bole GG, Brandt KD, Cooke DV, Greenwald RA (1999) Development of criteria for osteoarthritis. J Rheumatol 26:1959–1963 Altman RD, Blach DA, Bole GG, Brandt KD, Cooke DV, Greenwald RA (1999) Development of criteria for osteoarthritis. J Rheumatol 26:1959–1963
25.
go back to reference Kellgren JS, Lawrence JS (1957) Radiological assessment of osteoarthrosis. Ann Rheum Dis 16:494–502PubMed Kellgren JS, Lawrence JS (1957) Radiological assessment of osteoarthrosis. Ann Rheum Dis 16:494–502PubMed
26.
go back to reference Huskisson EC (1983) Visual analogue scale. In: Melzack R (ed) Pain measurement and assessment. Raven Press, New York, pp 33–37 Huskisson EC (1983) Visual analogue scale. In: Melzack R (ed) Pain measurement and assessment. Raven Press, New York, pp 33–37
27.
go back to reference Fisher AA (1986) Pressure threshold meter: its use for quantification of tender spots. Arch Phys Med Rehabil 67:836–838 Fisher AA (1986) Pressure threshold meter: its use for quantification of tender spots. Arch Phys Med Rehabil 67:836–838
28.
go back to reference Yurtkuran M, Çeliktaş M (1996) A randomised controlled trial of balneotherapy in the treatment of patients with primary fibromyalgia syndrome. Phys Rehabil Kur Med 6:109–112 Yurtkuran M, Çeliktaş M (1996) A randomised controlled trial of balneotherapy in the treatment of patients with primary fibromyalgia syndrome. Phys Rehabil Kur Med 6:109–112
29.
go back to reference Bellamy N, Buchanan WW, Goldsmith CH, Camphell J, Stiff LW (1986) Validation study of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum 29:1039–1049 Bellamy N, Buchanan WW, Goldsmith CH, Camphell J, Stiff LW (1986) Validation study of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum 29:1039–1049
30.
go back to reference Bellamy N, Buchanan WW, Goldsmith CH, Camphell J, Stiff LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip and knee. J Rheumatol 15:1833–1840PubMed Bellamy N, Buchanan WW, Goldsmith CH, Camphell J, Stiff LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip and knee. J Rheumatol 15:1833–1840PubMed
31.
go back to reference Bores M, Brooks P, Strand VC et al (1998) The OMERACT filter for outcome measures in rheumatology. J Rheumatol 25:198–199 Bores M, Brooks P, Strand VC et al (1998) The OMERACT filter for outcome measures in rheumatology. J Rheumatol 25:198–199
32.
go back to reference Martini CJM, Waugh IM (1978) A method for self. Assessment of disability before and after hip replacement operation. BMJ 2:258–259 Martini CJM, Waugh IM (1978) A method for self. Assessment of disability before and after hip replacement operation. BMJ 2:258–259
33.
go back to reference Kucukdeveci AA, Mckenna SP, Kutlay S, Gursel Y, Whalley D, Arasıl T (2000) The development and psychometric assessment of the Turkish version of the Nottingham Health Profile. Int J Rehabil Res 23:31–38PubMedCrossRef Kucukdeveci AA, Mckenna SP, Kutlay S, Gursel Y, Whalley D, Arasıl T (2000) The development and psychometric assessment of the Turkish version of the Nottingham Health Profile. Int J Rehabil Res 23:31–38PubMedCrossRef
34.
go back to reference Becker BE (1994) The biologic aspects of hydrotherapy. J Back Musculoskeletal Rehabil 4:255–264 Becker BE (1994) The biologic aspects of hydrotherapy. J Back Musculoskeletal Rehabil 4:255–264
35.
36.
go back to reference Sukenik S (1994) Spa treatment for arthritis at the Dead Sea area. Editorial. Isr J Med Sci 30:919–921PubMed Sukenik S (1994) Spa treatment for arthritis at the Dead Sea area. Editorial. Isr J Med Sci 30:919–921PubMed
37.
go back to reference O’hare JP, Heywood A, Summerhayes C et al (1985) Observations on the effect of immersion in bath spa water. BMJ 291:1747–1751PubMedCrossRef O’hare JP, Heywood A, Summerhayes C et al (1985) Observations on the effect of immersion in bath spa water. BMJ 291:1747–1751PubMedCrossRef
38.
go back to reference Lange U, Muller-Ladner U, Schmidt KL (2005) Balneotherapy in rheumatic diseases—an overview of novel and known aspects. Rheumatol Int 12:1–3 Lange U, Muller-Ladner U, Schmidt KL (2005) Balneotherapy in rheumatic diseases—an overview of novel and known aspects. Rheumatol Int 12:1–3
39.
go back to reference Forestier R (2001) Magnitude and duration of the effects of two spa therapy courses on knee and hip osteoarthritis: an open prospective study in 51 consecutive patients. With fibromyalgia syndome. Clin Rheumatol 20:15–19CrossRef Forestier R (2001) Magnitude and duration of the effects of two spa therapy courses on knee and hip osteoarthritis: an open prospective study in 51 consecutive patients. With fibromyalgia syndome. Clin Rheumatol 20:15–19CrossRef
40.
go back to reference Lehmann J, Lateur B (1994) Ultrasound, shortwave, microwave, laser, superficial heat and cold in the treatment of pain. In: Wall P, Melzack R (eds) Textbook of pain. Churchill Livingstone, London, pp 1237–1246 Lehmann J, Lateur B (1994) Ultrasound, shortwave, microwave, laser, superficial heat and cold in the treatment of pain. In: Wall P, Melzack R (eds) Textbook of pain. Churchill Livingstone, London, pp 1237–1246
41.
go back to reference Yurtkuran M, Ulus H, İrdesel J (1993) The effect of balneotherapy on plasma endorphine level in patients with osteoarthritis. Phys Rehabil Kur Med 3:130–138CrossRef Yurtkuran M, Ulus H, İrdesel J (1993) The effect of balneotherapy on plasma endorphine level in patients with osteoarthritis. Phys Rehabil Kur Med 3:130–138CrossRef
42.
go back to reference Davis B, Harrison R (1988) Treatment of specific conditions. In: Davis B, Harrison R (eds) Hydrotherapy in practise. Churchill Livingstone, Singapore, pp 137–170 Davis B, Harrison R (1988) Treatment of specific conditions. In: Davis B, Harrison R (eds) Hydrotherapy in practise. Churchill Livingstone, Singapore, pp 137–170
43.
go back to reference Kondrad K, Tatrai T, Hunka A, Vereckei E, Korondi I (1992) Controlled trial of balneotherapy in treatment of low back pain. Ann Rheum Dis 51:820–822CrossRef Kondrad K, Tatrai T, Hunka A, Vereckei E, Korondi I (1992) Controlled trial of balneotherapy in treatment of low back pain. Ann Rheum Dis 51:820–822CrossRef
44.
go back to reference Böhmer H, Resch KL, Gutenbrunner C (1999) Sulfat-Heilwässer-eine zeitgemäße medikamentöse Alternative? Phys Rehabil Kur Med 9:1–5 Böhmer H, Resch KL, Gutenbrunner C (1999) Sulfat-Heilwässer-eine zeitgemäße medikamentöse Alternative? Phys Rehabil Kur Med 9:1–5
45.
go back to reference Karagülle MZ, Tütüncü ZN, Aslan O et al (1996) Effects of therma sulfur bath cure on adjuvant arthritic rats. Phys Rehabil Kur Med 6:53–57 Karagülle MZ, Tütüncü ZN, Aslan O et al (1996) Effects of therma sulfur bath cure on adjuvant arthritic rats. Phys Rehabil Kur Med 6:53–57
46.
go back to reference Kovacs I, Bender T (2002) The therapeutic effects of Cserkeszölö thermal water in osteoarthritis of the knee: a double blind, controlled, follow up study. Rheumatol Int 21:258–261CrossRef Kovacs I, Bender T (2002) The therapeutic effects of Cserkeszölö thermal water in osteoarthritis of the knee: a double blind, controlled, follow up study. Rheumatol Int 21:258–261CrossRef
47.
go back to reference Sukenic S, Flusser D, Codish S, Ahu-Shakra M (1999) Balneotherapy at the dead sea area for knee osteoarthritis. Isr Med Assoc J 1:83–85 Sukenic S, Flusser D, Codish S, Ahu-Shakra M (1999) Balneotherapy at the dead sea area for knee osteoarthritis. Isr Med Assoc J 1:83–85
48.
go back to reference Wigler I, Elkayam O, Paran D, Yaron M (1995) Spa therapy for gonarthrosis: a prospective study. Rheumatol Int 15:65–68PubMedCrossRef Wigler I, Elkayam O, Paran D, Yaron M (1995) Spa therapy for gonarthrosis: a prospective study. Rheumatol Int 15:65–68PubMedCrossRef
49.
go back to reference Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a Spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomized controlled trial. Br J Rheumatol 36:77–81PubMedCrossRef Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a Spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomized controlled trial. Br J Rheumatol 36:77–81PubMedCrossRef
50.
go back to reference Goldsmith CH, Boers M, Bombardier C, Tugwell P (1993) Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patient and trial profiles. OMERACT committee. J Rheumatol 20:561–565PubMed Goldsmith CH, Boers M, Bombardier C, Tugwell P (1993) Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patient and trial profiles. OMERACT committee. J Rheumatol 20:561–565PubMed
51.
go back to reference Bellamy N, Kirwan J, Boers M, Brooks P, Strand V, Tugwell P (1997) Recommendations for a core set outcome measure for future phase III clinical trials in knee, hip and hand OA. Consensus development at OMERACT III. J Rheumatol 24:799–802PubMed Bellamy N, Kirwan J, Boers M, Brooks P, Strand V, Tugwell P (1997) Recommendations for a core set outcome measure for future phase III clinical trials in knee, hip and hand OA. Consensus development at OMERACT III. J Rheumatol 24:799–802PubMed
52.
go back to reference Angst F, Aeschlimann A, Steiner W, Stucki G (2001) Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention. Ann Rheum Dis 60:834–840PubMed Angst F, Aeschlimann A, Steiner W, Stucki G (2001) Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention. Ann Rheum Dis 60:834–840PubMed
53.
go back to reference Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W (2004) Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain 8(4):283–291PubMedCrossRef Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W (2004) Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain 8(4):283–291PubMedCrossRef
54.
go back to reference Wann-Hansson C, Hallberg I, Risberg B et al (2004) A comparison of the Nottingham Health Profile and Short Form 36 Health Survey in patients with chronic lower limb ischaemia in a longitudinal perspective. Health Qual Life Outcomes 2(1):9PubMedCrossRef Wann-Hansson C, Hallberg I, Risberg B et al (2004) A comparison of the Nottingham Health Profile and Short Form 36 Health Survey in patients with chronic lower limb ischaemia in a longitudinal perspective. Health Qual Life Outcomes 2(1):9PubMedCrossRef
55.
go back to reference Szücs L, Ratko L, Lesko T, Szoor I, Genti G et al (1989) Double blind trial on the effectiveness of the Puspokladany thermal water on arthrosis of the knee joint. Roy Soc Health J 109:7–9 Szücs L, Ratko L, Lesko T, Szoor I, Genti G et al (1989) Double blind trial on the effectiveness of the Puspokladany thermal water on arthrosis of the knee joint. Roy Soc Health J 109:7–9
Metadata
Title
Balneotherapy and tap water therapy in the treatment of knee osteoarthritis
Authors
Merih Yurtkuran
Mustafa Yurtkuran
Alev Alp
Aşkın Nasırcılar
Ümit Bingöl
Lale Altan
Gülnazik Sarpdere
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 1/2006
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-006-0158-8

Other articles of this Issue 1/2006

Rheumatology International 1/2006 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.