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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

AZD9773 is a novel and potent anti-TNFα polyclonal ovine immune Fab

Authors: P Newham, P Ceuppens, G Davies, J Growcott

Published in: Critical Care | Special Issue 1/2011

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Excerpt

The release of cytokines into the circulation is an essential part of the inflammatory cascade that underlies sepsis. Experimental and clinical data have shown that the proinflammatory cytokine TNFα is a principal mediator of this cascade [1‐3]. The investigational drug AZD9773, intended for intravenous infusion, contains ovine immune fragments (Fabs) of IgG that bind to human (hu)-TNFα. Here we describe the in vitro and in vivo pharmacology of AZD9773. …
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Metadata
Title
AZD9773 is a novel and potent anti-TNFα polyclonal ovine immune Fab
Authors
P Newham
P Ceuppens
G Davies
J Growcott
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9681

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