Published in:
Open Access
01-04-2021 | Azathioprine | Guidelines
The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis
Authors:
Guiqiang Wang, Atsushi Tanaka, Hong Zhao, Jidong Jia, Xiong Ma, Kenichi Harada, Fu-Sheng Wang, Lai Wei, Qixia Wang, Ying Sun, Yuan Hong, Huiying Rao, Cumali Efe, George Lau, Diana Payawal, Rino Gani, Keith Lindor, Wasim Jafri, Masao Omata, Shiv Kumar Sarin
Published in:
Hepatology International
|
Issue 2/2021
Login to get access
Excerpt
Autoimmune hepatitis (AIH) is not a common disease but with increasing incidence in Asia–Pacific area. Although the etiology and pathogenesis are not completely clear, the disease is the result of loss of autoimmune tolerance in genetically predisposed individuals. AIH is characterized by autoantibodies, hypergammaglobulinemia, and interface hepatitis. Corticosteroids and azathioprine are standard regimens for AIH, which should be started after diagnosis. Alternative therapy should be considered for those who do not respond to standard regimens. End-stage AIH patient could be saved by liver transplantation. …