Published in:
01-10-2020 | Autopsy | Case Report
Tumor lysis syndrome in a patient with metastatic melanoma treated with nivolumab
Authors:
Saiho Sugimoto, Takeshi Terashima, Tatsuya Yamashita, Noriho Iida, Masaaki Kitahara, Yuji Hodo, Tetsuro Shimakami, Hajime Takatori, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Yukihiro Shirota, Katsuaki Sato, Eishiro Mizukoshi, Masao Honda, Kenichi Harada, Shuichi Kaneko
Published in:
Clinical Journal of Gastroenterology
|
Issue 5/2020
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Abstract
A 79-year-old man with metastatic melanoma of the right maxillary sinus and multiple liver metastases received a single dose of nivolumab. Eight days later, he experienced impaired consciousness, accompanied by abnormal laboratory and electrocardiographic findings. He was therefore diagnosed with tumor lysis syndrome (TLS). Laboratory and electrocardiographic findings improved immediately after continuous hemodiafiltration; however, he died 22 days after receiving nivolumab. Autopsy revealed massive tumor necrosis in the liver. There are few case reports of TLS associated with immune checkpoint inhibitors, indicating that we should be prepared to manage especially in a patient with liver involvement of high tumor burden.