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Published in: World Journal of Surgical Oncology 1/2012

Open Access 01-12-2012 | Case report

Autologous formalin-fixed tumor vaccine suppressed re-recurrence of HCV-related hepatocellular carcinoma following 29 unsuccessful treatments with extensive conventional therapy: a case report

Authors: Toshio Inui, Tadao Ohno

Published in: World Journal of Surgical Oncology | Issue 1/2012

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Abstract

Treatment of hepatocellular carcinoma (HCC) with autologous formalin-fixed tumor vaccine after primary resection has been shown to suppress the recurrence of hepatitis B virus-associated HCC, but the effect of this treatment on hepatitis C virus (HCV)-related disease has not yet been clarified. Here, we report a case of a patient with repeat recurrent HCC that was associated with HCV who had endured 29 episodes of HCC recurrence despite a variety of therapy using conventional methods. Finally, treatment with a single course of autologous formalin-fixed tumor vaccine resulted in suppression of potential further re-recurrence of HCC for more than 43 months without any additional treatment.
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Literature
1.
go back to reference Kuang M, Peng BG, Lu MD, Liang LJ, Huang JF, He Q, Hua YP, Totsuka S, Liu SQ, Leong KW, Ohno T: Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004, 10: 1574-1579. 10.1158/1078-0432.CCR-03-0071.CrossRefPubMed Kuang M, Peng BG, Lu MD, Liang LJ, Huang JF, He Q, Hua YP, Totsuka S, Liu SQ, Leong KW, Ohno T: Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004, 10: 1574-1579. 10.1158/1078-0432.CCR-03-0071.CrossRefPubMed
2.
go back to reference Nagano H, Monden M: FAIT (FU arterial infusion and interferon therapy) for hepatocellular carcinoma. Nihon Rinsho. 2006, 64: 1314-1318.PubMed Nagano H, Monden M: FAIT (FU arterial infusion and interferon therapy) for hepatocellular carcinoma. Nihon Rinsho. 2006, 64: 1314-1318.PubMed
3.
go back to reference Nagano H, Miyamoto A, Wada H, Ota H, Marubashi S, Takeda Y, Dono K, Umeshita K, Sakon M, Monden M: Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer. 2007, 110: 2493-2501. 10.1002/cncr.23033.CrossRefPubMed Nagano H, Miyamoto A, Wada H, Ota H, Marubashi S, Takeda Y, Dono K, Umeshita K, Sakon M, Monden M: Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer. 2007, 110: 2493-2501. 10.1002/cncr.23033.CrossRefPubMed
4.
go back to reference Wada H, Nagano H, Noda T, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Sakon M, Wakasa K, Monden M: Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection. J Gastroenterol. 2007, 42: 501-506. 10.1007/s00535-007-2028-x.CrossRefPubMed Wada H, Nagano H, Noda T, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Sakon M, Wakasa K, Monden M: Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection. J Gastroenterol. 2007, 42: 501-506. 10.1007/s00535-007-2028-x.CrossRefPubMed
5.
go back to reference Ishikawa E, Tsuboi K, Yamamoto T, Muroi A, Enomoto T, Takano S, Matsumura A, Ohno T: A clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci. 2007, 98: 1226-1233. 10.1111/j.1349-7006.2007.00518.x.CrossRefPubMed Ishikawa E, Tsuboi K, Yamamoto T, Muroi A, Enomoto T, Takano S, Matsumura A, Ohno T: A clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci. 2007, 98: 1226-1233. 10.1111/j.1349-7006.2007.00518.x.CrossRefPubMed
6.
go back to reference Ikeda K, Kobayashi M, Saitoh S, Someya T, Hosaka T, Akuta N, Suzuki F, Tsubota A, Suzuki Y, Arase Y, Kumada H: Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients. Oncology. 2003, 65: 204-210. 10.1159/000074472.CrossRefPubMed Ikeda K, Kobayashi M, Saitoh S, Someya T, Hosaka T, Akuta N, Suzuki F, Tsubota A, Suzuki Y, Arase Y, Kumada H: Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients. Oncology. 2003, 65: 204-210. 10.1159/000074472.CrossRefPubMed
Metadata
Title
Autologous formalin-fixed tumor vaccine suppressed re-recurrence of HCV-related hepatocellular carcinoma following 29 unsuccessful treatments with extensive conventional therapy: a case report
Authors
Toshio Inui
Tadao Ohno
Publication date
01-12-2012
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-10-144

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