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Published in: Endocrine 2/2019

01-11-2019 | Letter to the Editor

Author Response to “In Defense of the UVB-Vitamin D-Cancer Hypothesis.”

Author: Ronald B. Brown

Published in: Endocrine | Issue 2/2019

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Excerpt

In his letter criticizing my article on Vitamin D, cancer, and dysregulated phosphate metabolism, William B. Grant, Ph.D., declares a conflict of interest, writing that he receives funding from a well-known vitamin supplement firm. In researching my article, my main focus was purposively not placed on the plethora of research studies from the past showing mixed findings of vitamin D supplementation and cancer prevention—a body of research which Dr Grant referred to as supporting the UVB-vitamin D-cancer hypothesis. Rather, my objectives included briefly summarizing findings from the most recent large clinical trials of vitamin D supplementation and cancer, such as the Vitamin D and Omega 3 Trial (VITAL) [1] and the Vitamin D Assessment study (ViDA) [2]. Although these major studies do not support cancer prevention with vitamin D supplementation, nevertheless, my article stressed that vitamin D supplementation and cancer prevention remains an unsettled issue due to variable findings. …
Literature
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go back to reference J.E. Manson, N.R. Cook, I.-M. Lee, W. Christen, S.S. Bassuk, S. Mora, H. Gibson, D. Gordon, T. Copeland, D. D’Agostino, Vitamin D supplements and prevention of cancer and cardiovascular disease. N. Engl. J. Med. 380(1), 33–44 (2019)CrossRef J.E. Manson, N.R. Cook, I.-M. Lee, W. Christen, S.S. Bassuk, S. Mora, H. Gibson, D. Gordon, T. Copeland, D. D’Agostino, Vitamin D supplements and prevention of cancer and cardiovascular disease. N. Engl. J. Med. 380(1), 33–44 (2019)CrossRef
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go back to reference R. Scragg, K.-T. Khaw, L. Toop, J. Sluyter, C.M. Lawes, D. Waayer, E. Giovannucci, C.A. Camargo, Monthly high-dose vitamin D supplementation and cancer risk: a post hoc analysis of the vitamin D assessment randomized clinical trial. JAMA Oncol. 4(11), e182178–e182178 (2018)CrossRef R. Scragg, K.-T. Khaw, L. Toop, J. Sluyter, C.M. Lawes, D. Waayer, E. Giovannucci, C.A. Camargo, Monthly high-dose vitamin D supplementation and cancer risk: a post hoc analysis of the vitamin D assessment randomized clinical trial. JAMA Oncol. 4(11), e182178–e182178 (2018)CrossRef
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go back to reference C.F. Garland, F.C. Garland, Do sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol. 9(3), 227–231 (1980)CrossRef C.F. Garland, F.C. Garland, Do sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol. 9(3), 227–231 (1980)CrossRef
Metadata
Title
Author Response to “In Defense of the UVB-Vitamin D-Cancer Hypothesis.”
Author
Ronald B. Brown
Publication date
01-11-2019
Publisher
Springer US
Published in
Endocrine / Issue 2/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-019-02068-8

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