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Published in: Journal of Bone and Mineral Metabolism 4/2009

01-07-2009 | Case Report

Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man

Authors: Alexis de Rougemont, Marie-Gabrielle Mourot, Jean-Paul Riou

Published in: Journal of Bone and Mineral Metabolism | Issue 4/2009

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Abstract

For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of α-TSH suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge such a case has never been reported in the literature.
Literature
1.
go back to reference Zuniga S, Mendoza V, Espinoza IF, Zarate A, Mason M, Mercado M (1997) A plurihormonal TSH-secreting pituitary microadenoma: report of a case with an atypical clinical presentation and transient response to bromocriptine therapy. Endocr Pathol 8(1):81–86PubMedCrossRef Zuniga S, Mendoza V, Espinoza IF, Zarate A, Mason M, Mercado M (1997) A plurihormonal TSH-secreting pituitary microadenoma: report of a case with an atypical clinical presentation and transient response to bromocriptine therapy. Endocr Pathol 8(1):81–86PubMedCrossRef
2.
go back to reference Gurnell M, Rajanayagam O, Barbar I, Jones MK, Chatterjee VK (1998) Reversible pituitary enlargement in the syndrome of resistance to thyroid hormone. Thyroid 8(8):679–682PubMedCrossRef Gurnell M, Rajanayagam O, Barbar I, Jones MK, Chatterjee VK (1998) Reversible pituitary enlargement in the syndrome of resistance to thyroid hormone. Thyroid 8(8):679–682PubMedCrossRef
3.
go back to reference Sanno N, Teramoto A, Osamura RY (2001) Thyrotropin-secreting pituitary adenomas. Clinical and biological heterogeneity and current treatment. J Neurooncol 54(2):179–186PubMedCrossRef Sanno N, Teramoto A, Osamura RY (2001) Thyrotropin-secreting pituitary adenomas. Clinical and biological heterogeneity and current treatment. J Neurooncol 54(2):179–186PubMedCrossRef
4.
go back to reference Bonneville JF (2000) Pituitary adenomas: value of MR imaging. J Radiol 81(9):939–942PubMed Bonneville JF (2000) Pituitary adenomas: value of MR imaging. J Radiol 81(9):939–942PubMed
5.
go back to reference Wu YY, Chang HY, Lin JD, Chen KW, Huang YY, Jung SM (2003) Clinical characteristics of patients with thyrotropin-secreting pituitary adenoma. J Formos Med Assoc 102(3):164–171PubMed Wu YY, Chang HY, Lin JD, Chen KW, Huang YY, Jung SM (2003) Clinical characteristics of patients with thyrotropin-secreting pituitary adenoma. J Formos Med Assoc 102(3):164–171PubMed
6.
go back to reference Beck-Peccoz P, Persani L, Mantovani S, Cortelazzi D, Asteria C (1996) Thyrotropin-secreting pituitary adenomas. Metabolism 45(8 suppl 1):75–79PubMedCrossRef Beck-Peccoz P, Persani L, Mantovani S, Cortelazzi D, Asteria C (1996) Thyrotropin-secreting pituitary adenomas. Metabolism 45(8 suppl 1):75–79PubMedCrossRef
7.
go back to reference Boni G, Ferdeghini M, Bellina CR, Matteucci F, Castro Lopez E, Parenti G, Canapicchi R, Bianchi R (1995) [111In-DTPA-D-Phe]-octreotide scintigraphy in functioning and non-functioning pituitary adenomas. Q J Nucl Med 39(4 Suppl 1):90–93PubMed Boni G, Ferdeghini M, Bellina CR, Matteucci F, Castro Lopez E, Parenti G, Canapicchi R, Bianchi R (1995) [111In-DTPA-D-Phe]-octreotide scintigraphy in functioning and non-functioning pituitary adenomas. Q J Nucl Med 39(4 Suppl 1):90–93PubMed
8.
go back to reference Socin HV, Chanson P, Delemer B, Tabarin A, Rohmer V, Mockel J, Stevenaert A, Beckers A (2003) The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol 148(4):433–442PubMedCrossRef Socin HV, Chanson P, Delemer B, Tabarin A, Rohmer V, Mockel J, Stevenaert A, Beckers A (2003) The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol 148(4):433–442PubMedCrossRef
9.
go back to reference Sarlis NJ, Gourgiotis L, Koch CA, Skarulis MC, Brucker-Davis F, Doppman JL, Oldfield EH, Patronas NJ (2003) MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation. AJR Am J Roentgenol 181(2):577–582PubMed Sarlis NJ, Gourgiotis L, Koch CA, Skarulis MC, Brucker-Davis F, Doppman JL, Oldfield EH, Patronas NJ (2003) MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation. AJR Am J Roentgenol 181(2):577–582PubMed
10.
go back to reference Pasquini E, Faustini-Fustini M, Sciarretta V, Saggese D, Roncaroli F, Serra D, Frank G (2003) Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. Eur J Endocrinol 148(2):253–257PubMedCrossRef Pasquini E, Faustini-Fustini M, Sciarretta V, Saggese D, Roncaroli F, Serra D, Frank G (2003) Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. Eur J Endocrinol 148(2):253–257PubMedCrossRef
11.
go back to reference Lindboe CF, Unsgard G, Myhr G, Scott H (1993) ACTH and TSH producing ectopic suprasellar pituitary adenoma of the hypothalamic region: case report. Clin Neuropathol 12(3):138–141PubMed Lindboe CF, Unsgard G, Myhr G, Scott H (1993) ACTH and TSH producing ectopic suprasellar pituitary adenoma of the hypothalamic region: case report. Clin Neuropathol 12(3):138–141PubMed
12.
go back to reference Katznelson L, Alexander JM, Klibanski A (1993) Clinical review 45: clinically nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 76(5):1089–1094PubMedCrossRef Katznelson L, Alexander JM, Klibanski A (1993) Clinical review 45: clinically nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 76(5):1089–1094PubMedCrossRef
13.
go back to reference Akiyoshi F, Okamura K, Fujikawa M, Sato K, Yoshinari M, Mizokami T, Hattori K, Kuwayama A, Takahashi Y, Fujishima M (1996) Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma. Thyroid 6(6):619–625PubMedCrossRef Akiyoshi F, Okamura K, Fujikawa M, Sato K, Yoshinari M, Mizokami T, Hattori K, Kuwayama A, Takahashi Y, Fujishima M (1996) Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma. Thyroid 6(6):619–625PubMedCrossRef
14.
go back to reference Safer JD, Colan SD, Fraser LM, Wondisford FE (2001) A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma. Thyroid 11(3):281–291PubMedCrossRef Safer JD, Colan SD, Fraser LM, Wondisford FE (2001) A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma. Thyroid 11(3):281–291PubMedCrossRef
15.
go back to reference Vlaeminck-Guillem V, Wemeau JL (1999) Thyroid hormone resistance syndromes: clinical aspects. Rev Med Interne 20(12):1114–1122PubMedCrossRef Vlaeminck-Guillem V, Wemeau JL (1999) Thyroid hormone resistance syndromes: clinical aspects. Rev Med Interne 20(12):1114–1122PubMedCrossRef
16.
go back to reference Glezer A, D’Alva CB, Salgado LR, Musolino NR, Serafini P, Vieira JG, Bronstein MD (2002) Pitfalls in pituitary diagnosis: peculiarities of three cases. Clin Endocrinol (Oxf) 57(1):135–139CrossRef Glezer A, D’Alva CB, Salgado LR, Musolino NR, Serafini P, Vieira JG, Bronstein MD (2002) Pitfalls in pituitary diagnosis: peculiarities of three cases. Clin Endocrinol (Oxf) 57(1):135–139CrossRef
17.
18.
go back to reference Prader A, Illig R, Uehlinger E, Stalder G (1959) Rickets following bone tumor. Helv Paediatr Acta 14:554–565PubMed Prader A, Illig R, Uehlinger E, Stalder G (1959) Rickets following bone tumor. Helv Paediatr Acta 14:554–565PubMed
19.
go back to reference Sahin M, Basoglu T, Albayrak S, Canbaz F, Yapici O (2001) Pentavalent technetium-99 m DMSA uptake in pseudofractures of osteomalacia. Clin Nucl Med 26(1):62–64PubMedCrossRef Sahin M, Basoglu T, Albayrak S, Canbaz F, Yapici O (2001) Pentavalent technetium-99 m DMSA uptake in pseudofractures of osteomalacia. Clin Nucl Med 26(1):62–64PubMedCrossRef
20.
go back to reference Garcia CA, Spencer RP (2002) Bone and In-111 octreotide imaging in oncogenic osteomalacia: a case report. Clin Nucl Med 27(8):582–583PubMedCrossRef Garcia CA, Spencer RP (2002) Bone and In-111 octreotide imaging in oncogenic osteomalacia: a case report. Clin Nucl Med 27(8):582–583PubMedCrossRef
21.
22.
go back to reference Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M (2003) TSH is a negative regulator of skeletal remodeling. Cell 115(2):151–162PubMedCrossRef Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M (2003) TSH is a negative regulator of skeletal remodeling. Cell 115(2):151–162PubMedCrossRef
23.
go back to reference Simsek G, Karter Y, Aydin S, Uzun H (2003) Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism. Chin J Physiol 46(4):181–186PubMed Simsek G, Karter Y, Aydin S, Uzun H (2003) Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism. Chin J Physiol 46(4):181–186PubMed
Metadata
Title
Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man
Authors
Alexis de Rougemont
Marie-Gabrielle Mourot
Jean-Paul Riou
Publication date
01-07-2009
Publisher
Springer Japan
Published in
Journal of Bone and Mineral Metabolism / Issue 4/2009
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-009-0050-1

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