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Published in: Virology Journal 1/2012

Open Access 01-12-2012 | Case Report

Attenuation of an adult T-cell leukemia skin lesion after treatment of a concomitant herpes simplex infection: a case study

Authors: Hajime Tomita, Fumihide Ogawa, Sayaka Kuwatsuka, Fumi Toriyama, Shinichirou Yasumoto, Shimeru Kamihira, Atsushi Utani

Published in: Virology Journal | Issue 1/2012

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Abstract

We report the development and treatment of eczema herpeticum in a 51-year-old male suffering from adult T-cell leukemia (ATL). Lesions of eczema herpeticum coexisted with the skin lesions of ATL. Treatment of eczema herpeticum resulted in a concomitant improvement in the symptoms of ATL, including a reduction in the size of the ATL plaques, for over 2 months before relapse.
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Literature
1.
go back to reference Santmyire-Rosenberger BR, Nigra TP: Psoriasis herpeticum: three cases of Kaposi’s varicelliform eruption in psoriasis. J. Am. Acad. Dermatol. 2005, 53: 52-56. 10.1016/j.jaad.2005.01.140.PubMedCrossRef Santmyire-Rosenberger BR, Nigra TP: Psoriasis herpeticum: three cases of Kaposi’s varicelliform eruption in psoriasis. J. Am. Acad. Dermatol. 2005, 53: 52-56. 10.1016/j.jaad.2005.01.140.PubMedCrossRef
2.
go back to reference Toulza F, Heaps A, Tanaka Y, Taylor GP, Bangham CR: High frequency of CD4 + FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood. 2008, 111: 5047-5053. 10.1182/blood-2007-10-118539.PubMedPubMedCentralCrossRef Toulza F, Heaps A, Tanaka Y, Taylor GP, Bangham CR: High frequency of CD4 + FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood. 2008, 111: 5047-5053. 10.1182/blood-2007-10-118539.PubMedPubMedCentralCrossRef
3.
go back to reference Rouse BT, Suvas S: Regulatory cells and infectious agents: detentes cordiale and contraire. J Immunol. 2004, 173: 2211-2215.PubMedCrossRef Rouse BT, Suvas S: Regulatory cells and infectious agents: detentes cordiale and contraire. J Immunol. 2004, 173: 2211-2215.PubMedCrossRef
4.
go back to reference Fernandez MA, Puttur FK, Wang YM, Howden W, Alexander SI, Jones CA: T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. J Immunol. 2008, 180: 1556-1564.PubMedCrossRef Fernandez MA, Puttur FK, Wang YM, Howden W, Alexander SI, Jones CA: T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. J Immunol. 2008, 180: 1556-1564.PubMedCrossRef
5.
go back to reference Li-Weber M, Giaisi M, Chlichlia K, Khazaie K, Krammer PH: Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells. Eur J Immunol. 2001, 31: 2623-2632. 10.1002/1521-4141(200109)31:9<2623::AID-IMMU2623>3.0.CO;2-4.PubMedCrossRef Li-Weber M, Giaisi M, Chlichlia K, Khazaie K, Krammer PH: Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells. Eur J Immunol. 2001, 31: 2623-2632. 10.1002/1521-4141(200109)31:9<2623::AID-IMMU2623>3.0.CO;2-4.PubMedCrossRef
6.
go back to reference Howell MD, Wollenberg A, Gallo RL, Flaig M, Streib JE, Wong C, Pavicic T, Boguniewicz M, Leung DY: Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol. 2006, 117: 836-841. 10.1016/j.jaci.2005.12.1345.PubMedPubMedCentralCrossRef Howell MD, Wollenberg A, Gallo RL, Flaig M, Streib JE, Wong C, Pavicic T, Boguniewicz M, Leung DY: Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol. 2006, 117: 836-841. 10.1016/j.jaci.2005.12.1345.PubMedPubMedCentralCrossRef
7.
go back to reference Dodon MD, Li Z, Hamaia S, Gazzolo L: Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol. 2004, 85: 1921-1932. 10.1099/vir.0.79921-0.PubMedCrossRef Dodon MD, Li Z, Hamaia S, Gazzolo L: Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol. 2004, 85: 1921-1932. 10.1099/vir.0.79921-0.PubMedCrossRef
8.
go back to reference Kawakami Y, Tomimori Y, Yumoto K, Hasegawa S, Ando T, Tagaya Y, Crotty S, Kawakami T: Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med. 2009, 206: 1219-1225. 10.1084/jem.20082835.PubMedPubMedCentralCrossRef Kawakami Y, Tomimori Y, Yumoto K, Hasegawa S, Ando T, Tagaya Y, Crotty S, Kawakami T: Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med. 2009, 206: 1219-1225. 10.1084/jem.20082835.PubMedPubMedCentralCrossRef
9.
go back to reference Whittaker SJ, Foss FM: Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma. Cancer Treat Rev. 2007, 33: 146-160. 10.1016/j.ctrv.2006.08.006.PubMedCrossRef Whittaker SJ, Foss FM: Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma. Cancer Treat Rev. 2007, 33: 146-160. 10.1016/j.ctrv.2006.08.006.PubMedCrossRef
10.
go back to reference Suryawanshi A, Veiga-Parga T, Rajasagi NK, Reddy PB, Sehrawat S, Sharma S, Rouse BT: Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J Immunol. 2011, 187: 1919-30. 10.4049/jimmunol.1100736.PubMedPubMedCentralCrossRef Suryawanshi A, Veiga-Parga T, Rajasagi NK, Reddy PB, Sehrawat S, Sharma S, Rouse BT: Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J Immunol. 2011, 187: 1919-30. 10.4049/jimmunol.1100736.PubMedPubMedCentralCrossRef
Metadata
Title
Attenuation of an adult T-cell leukemia skin lesion after treatment of a concomitant herpes simplex infection: a case study
Authors
Hajime Tomita
Fumihide Ogawa
Sayaka Kuwatsuka
Fumi Toriyama
Shinichirou Yasumoto
Shimeru Kamihira
Atsushi Utani
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2012
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-9-224

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