Published in:
01-06-2007 | Original Article
Atrial natriuretic peptide increases urinary albumin excretion in people with normoalbuminuric type-2 diabetes
Published in: Irish Journal of Medical Science (1971 -) | Issue 2/2007
Login to get accessAbstract
Background
Atrial natriuretic peptide (ANP) is elevated in patients with type-2 diabetes and microalbuminuria. The purpose of this study is to evaluate if ANP increases Urinary Albumin Eaxcretion Rate (UAER) in type-2 diabetes.
Methods
Eight normoalbuminuric diabetic subjects underwent a randomised single blind study of 60 min intravenous infusion of ANP or vehicle. Eight non-diabetic controls underwent ANP infusion alone. Seven normoalbuminuric type-2 diabetes subjects received further ANP infusions during euglycaemia and during hyperglycaemia.
Results
ANP increased urinary sodium (191.3 ± 80.7 to 529.2 ± 263.4 μmol/min, mean ± SD, and P < 0.001) and UAER (72.2 ± 73.4 to 224.9 ± 182.9.5 μg/min, and P < 0.01) in diabetic subjects. In controls, UAER did not change significantly (P = 0.16); however, the natriuretic response to ANP was similar to diabetic subjects (P = 0.98). Hyperglycaemic did not enhance the albuminuric response to ANP (P = 0.88).
Conclusion
ANP increases UAER in normoalbuminuric type-2 diabetic subjects.