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General Thoracic and Cardiovascular Surgery
Published in: General Thoracic and Cardiovascular Surgery 5/2023

28-08-2022 | Atrial Fibrillation | Original Article

Shunt and pace: a novel experimental model of atrial fibrillation with a volume-loaded left atrium

Authors: Hiroya Ohmori, Shun-ichiro Sakamoto, Yasuo Miyagi, Yosuke Ishii, Takashi Nitta

Published in: General Thoracic and Cardiovascular Surgery | Issue 5/2023

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Abstract

Background

Atrial fibrillation (AF) is frequently seen in patients with a volume-loaded left atrium (LA) such as mitral valve regurgitation (MR). Previous animal models have incomplete relevance to human AF associated with MR.

Methods

A novel experimental model with a combination of volume loading of LA by creating a shunt from the subclavian artery to pulmonary artery and electrical remodeling induced by continuous rapid LA pacing was designed and the electrophysiological effects were examined in 10 canines. Five weeks after the shunt surgery, the entire atrial epicardium was mapped during sustained AF with form-fitted electrode patches with 246 bipolar electrodes and a three-dimensional dynamic mapping system to characterize the induced AF.

Results

Three animals died of severe heart failure and pacing failure occurred in one. Remaining six animals were subjected to the analysis. The LA diameter increased progressively after the shunt surgery. Sustained AF was induced after 3 weeks of continuous rapid LA pacing in all animals. The activation maps revealed repetitive focal activations arising from the pulmonary veins, right or left atrial regions, and reentrant activations in the RA, which patterns of atrial activations are the same as those seen in human AF.

Conclusion

The animal model with a combination of LA volume load and electrical remodeling was relevant to human AF associated with LA volume load. Studies using the present model may provide further knowledges of AF and may be useful in examining the effects of pharmacological and non-pharmacological therapies.
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Metadata
Title
Shunt and pace: a novel experimental model of atrial fibrillation with a volume-loaded left atrium
Authors
Hiroya Ohmori
Shun-ichiro Sakamoto
Yasuo Miyagi
Yosuke Ishii
Takashi Nitta
Publication date
28-08-2022
Publisher
Springer Nature Singapore
Published in
General Thoracic and Cardiovascular Surgery / Issue 5/2023
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-022-01866-8

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