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01-02-2020 | Astrocytoma | Correspondence

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

Authors: Philipp Sievers, Daniel Schrimpf, Damian Stichel, David E. Reuss, Martin Hasselblatt, Christian Hagel, Ori Staszewski, Jürgen Hench, Stephan Frank, Sebastian Brandner, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Guido Reifenberger, Andreas von Deimling, Felix Sahm, David T. W. Jones

Published in: Acta Neuropathologica | Issue 2/2020

Excerpt

Low-grade glial (LGG) and glioneuronal tumors (LGGNT) of the central nervous system (CNS) are an extremely diverse group of tumors with overlapping morphological features [6], making their histological diagnosis sometimes challenging. Molecular analyses can be very useful in distinguishing these entities from their clinical or histological mimics and raises the possibility of personalized targeted therapy [7, 15]. In recent years, genome-wide DNA methylation profiling has proven to be a powerful technique to distinguish biological subgroups of brain tumors with characteristic alterations [1, 3, 11]. …

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Title: Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation
Authors: Philipp Sievers
Daniel Schrimpf
Damian Stichel
David E. Reuss
Martin Hasselblatt
Christian Hagel
Ori Staszewski
Jürgen Hench
Stephan Frank
Sebastian Brandner
Andrey Korshunov
Wolfgang Wick
Stefan M. Pfister
Guido Reifenberger
Andreas von Deimling
Felix Sahm
David T. W. Jones
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Astrocytoma
Astrocytoma
Astrocytoma
Published in: Acta Neuropathologica / Issue 2/2020
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-019-02097-7

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Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

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