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07-04-2024 | Original Article

Associations between life’s essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018

Authors: Tongyue Yang, Jiayi Yi, Mingwei Shao, Zhao Linlin, Jiao Wang, Fengjuan Huang, Feng Guo, Guijun Qin, Yanyan Zhao

Published in: Acta Diabetologica

Abstract

Background

Metabolic unhealth (MUH) is closely associated with cardiovascular disease (CVD). Life’s Essential 8 (LE8), a recently updated cardiovascular health (CVH) assessment, has some overlapping indicators with MUH but is more comprehensive and complicated than MUH. Given the close relationship between them, it is important to compare these two measurements.

Methods

This population-based cross-sectional survey included 20- to 80-year-old individuals from 7 National Health and Nutrition Examination Survey (NHANES) cycles between 2005 and 2018. Based on the parameters provided by the American Heart Association, the LE8 score (which ranges from 0 to 100) was used to classify CVH into three categories: low (0–49), moderate (50–79), and high (80–100). The MUH status was evaluated by blood glucose, blood pressure, and blood lipids. The associations were assessed by multivariable regression analysis, subgroup analysis, restricted cubic spline models, and sensitivity analysis.

Results

A total of 22,582 participants were enrolled (median of age was 45 years old), among them, 11,127 were female (weighted percentage, 49%) and 16,595 were classified as MUH (weighted percentage, 73.5%). The weighted median LE8 scores of metabolic health (MH) and MUH individuals are 73.75 and 59.38, respectively. Higher LE8 scores were linked to lower risks of MUH (odds ratio [OR] for every 10 scores increase, 0.53; 95% CI 0.51–0.55), and a nonlinear dose–response relationship was seen after the adjustment of potential confounders. This negative correlation between LE8 scores, and MUH was strengthened among elderly population.

Conclusions

Higher LE8 and its subscales scores were inversely and nonlinearly linked with the lower presence of MUH. MUH is consistent with LE8 scores, which can be considered as an alternative indicator when it is difficult to collect the information of health behaviors.

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Title: Associations between life’s essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018
Authors: Tongyue Yang
Jiayi Yi
Mingwei Shao
Zhao Linlin
Jiao Wang
Fengjuan Huang
Feng Guo
Guijun Qin
Yanyan Zhao
Publication date: 07-04-2024
Publisher: Springer Milan
Published in: Acta Diabetologica
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-024-02277-2

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