Published in:
Open Access
01-12-2014 | Poster presentation
Associations between ACTN3 and OPPERA pain-related genes in malocclusion
Authors:
JH Godel, BF Foley, R Nicot, MJ Horton, ER Barton, J Ferri, G Raoul, AR Vieira, JJ Sciote
Published in:
Molecular Pain
|
Special Issue 1/2014
Login to get access
Excerpt
We have investigated an orthognathic surgery population to determine how variation in masticatory muscle gene expression and genotype plays a key role in development of both jaw-deformation malocclusion and temporomandibular joint disorders (TMD). A gene of particular interest is ACTN3 since the common R577X polymorphism results in α-actinin-3 protein loss, reduced myofiber Z-disc structural integrity in skeletal muscle and decreased osteoblast/osteoclast activity in bone formation. Secondly, since the prevalence of TMD in this population is quite high (30%) we sought to determine if genes related to pain processes─previously identified in the Orofacial Pain: Prospective Evaluation and Risk Assessment Study (OPPERA) were differentially expressed. …
