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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2000

01-04-2000 | Review

Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men

Authors: Lars Fugger, Arne Svejgaard

Published in: Arthritis Research & Therapy | Issue 3/2000

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Abstract

Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
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Metadata
Title
Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
Authors
Lars Fugger
Arne Svejgaard
Publication date
01-04-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar89

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