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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2019

Open Access 01-12-2019 | Research article

Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study

Authors: Xiang Zeng, Dongling Liu, Xiangmei Zhao, Ling Chao, Yuchun Li, Huijun Li, Wen Li, Lihui Gui, Weidong Wu

Published in: BMC Pulmonary Medicine | Issue 1/2019

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Abstract

Background

Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, the relationship between BMD and lung function is inconsistent in the general population.

Methods

To investigate the association between BMD and lung function in a Chinese general population, a total of 1024 adults aged 40–70 years old from Qiliying (an industrial polluted exposure area) and Langgongmiao (the reference area with non-industrial pollution) were recruited and underwent BMD and spirometry tests.

Results

Both BMD and lung function levels were lower in the exposed area compared to the reference area. In addition, BMD and lung function levels were also lower in females compared to males. Both Spearman and partial correlation analyses showed that BMD was positively correlated with FVC and FEV1. After adjusting linear regression analyses for potential confounding factors, every 0.1 g/cm2 drop in BMD was associated with 53.0 mL decrease in FVC and 33.5 mL decrease in FEV1.

Conclusions

A reduction of BMD is associated with lower lung function in a general population from China.
Appendix
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Metadata
Title
Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study
Authors
Xiang Zeng
Dongling Liu
Xiangmei Zhao
Ling Chao
Yuchun Li
Huijun Li
Wen Li
Lihui Gui
Weidong Wu
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2019
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-019-1008-2

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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