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Published in: BMC Nephrology 1/2024

Open Access 01-12-2024 | Research

Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study

Authors: Mingan Li, Wenbo Yang, Lijun Song, Zhenghan Yang, Zhenchang Wang, Junfang Xian, Hao Wang

Published in: BMC Nephrology | Issue 1/2024

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Abstract

Objectives

To explore changes in cerebral blood flow (CBF) and white matter in hemodialysis patients.

Methods

Thirty-three hemodialysis patients who underwent two brain MRI at an interval of three years and 33 age- and sex-matched healthy controls (HC) underwent structural and arterial spin-labeling MRI examinations. Intergroup differences in CBF in the gray matter, white matter, and whole matter, and regional white matter hyperintensities (WMH) were analyzed. Based on the changes in CBF between the baseline and follow-up groups, the hemodialysis patients were divided into two subgroups: an increased CBF group and a decreased CBF group. Differences in CBF and WMH between the subgroups and HC were analyzed.

Results

Patients undergoing hemodialysis exhibited increased cerebral watershed (CW) WMH, deep WMH, and periventricular WMH (P < 0.01). The CBF of patients with decreased CBF was higher than that of HC at baseline (,P < 0.01) and lower than that of HC at follow-up (P < 0.01). Compared with the increased CBF group, obvious development of deep WMH was found in the decreased CBF group for the gray matter, white matter, and whole matter (P < 0.01).

Conclusions

WMH in hemodialysis patients were distributed in the deep white matter, periventricular white matter and CW, and progressed with the extension of hemodialysis duration. CBF in hemodialysis patients could manifest as both increased and decreased, and WMH in patients with decreased CBF developed severely with prolongation of hemodialysis duration.

Advances in knowledge

These findings provide a basis for exploring neuropathological changes of hemodialysis patients.
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Metadata
Title
Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study
Authors
Mingan Li
Wenbo Yang
Lijun Song
Zhenghan Yang
Zhenchang Wang
Junfang Xian
Hao Wang
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2024
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-024-03468-3

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