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Clinical Rheumatology
Published in: Clinical Rheumatology 2/2019

01-02-2019 | Original Article

Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population

Authors: Si Chen, Xiaoting Wen, Qian Wang, Jing Li, Yuan Li, Liubing Li, Hui Yuan, Fengchun Zhang, Yongzhe Li

Published in: Clinical Rheumatology | Issue 2/2019

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Abstract

The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in the BANK1 gene and polymyositis/dermatomyositis (PM/DM) in a Chinese Han population. In total, 363 PM patients, 654 DM patients, and 1280 healthy controls were recruited and genotyped using the Sequenom MassArray system. A significant allele association was observed in rs3733197 among the PM/DM patients (OR 0.81, 95%CI 0.70–0.94, Pc = 1.83 × 10−2). Notably, rs3733197 was associated with DM and PM/DM patients with ILD involvement (Pc = 0.026; Pc = 6.0 × 10−3, respectively). However, no statistically significant difference was observed in the allele or genotype frequencies of three SNPs (rs4522865, rs17266594, and rs10516487) among the DM, PM, and PM/DM patients and healthy controls (all Pc > 0.05). This study was the first to demonstrate that a BANK1 gene SNP (rs3733197) could confer genetic predisposition in PM/DM patients and PM/DM patients with ILD in a Chinese Han population.
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Metadata
Title
Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population
Authors
Si Chen
Xiaoting Wen
Qian Wang
Jing Li
Yuan Li
Liubing Li
Hui Yuan
Fengchun Zhang
Yongzhe Li
Publication date
01-02-2019
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 2/2019
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-018-4257-1

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