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Open Access 01-12-2009 | Research article

Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study

Authors: Ignacio Cruz-González, Esther Corral, María Sánchez-Ledesma, Angel Sánchez-Rodríguez, Cándido Martín-Luengo, Rogelio González-Sarmiento

Published in: BMC Cardiovascular Disorders | Issue 1/2009

Abstract

Background

It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension.

Methods

A prospective case-control observational study was performed. From a series of 950 consecutive patients followed up during 42 months, 48 patients with resistant hypertension were detected. 232 patients with controlled high blood pressure were also included.

Results

No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. However, genotype -786CC was more frequent in the group of patients with resistant hypertension (33.3%) than in the group of patients with controlled high blood pressure (17.7%) (p 0.03). Furthermore carriers of allele T (-786TC and -786TT) were more frequent in patients with controlled hypertension (82.3%) than those with resistant hypertension (66.7%) (Multivariate analysis; RR 2.09; 95% CI 1.03–4.24; p 0.004).

Conclusion

Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/9/35/prepub

Title: Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study
Authors: Ignacio Cruz-González
Esther Corral
María Sánchez-Ledesma
Angel Sánchez-Rodríguez
Cándido Martín-Luengo
Rogelio González-Sarmiento
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2009
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/1471-2261-9-35

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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