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BMC Geriatrics
Published in: BMC Geriatrics 1/2009

Open Access 01-12-2009 | Research article

Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population

Authors: Omar F Khabour, Essa S Abdelhalim, Ahmad Abu-Wardeh

Published in: BMC Geriatrics | Issue 1/2009

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Abstract

Background

Aging in animals is associated with high body oxidative stress, which might affect susceptibility and onset of age-related diseases, and the subsequent life span. Therefore, genes that modulate oxidative stress might play a role in determining longevity. In this study, we investigated whether the gene pool relevant to the SOD2-9T/C and MTHFR 677C/T polymorphisms changes as the Jordanian population ages.

Methods

Polymorphisms were genotyped in 130 elderly subjects (57 females and 73 males, mean age: 90.01 years) and 135 young control subjects (67 females and 68 males, mean age: 33.43 years).

Results

No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05).

Conclusion

SOD2-9T/C and MTHFR 677C/T gene polymorphisms do not seem to be important in Jordanian population for longevity phenotype.
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Metadata
Title
Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population
Authors
Omar F Khabour
Essa S Abdelhalim
Ahmad Abu-Wardeh
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2009
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/1471-2318-9-57

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