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The journal of nutrition, health & aging
Published in: The journal of nutrition, health & aging 1/2018

01-01-2018

Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults

Authors: Takehiko Doi, H. Makizako, K. Tsutsumimoto, R. Hotta, S. Nakakubo, K. Makino, T. Suzuki, H. Shimada

Published in: The journal of nutrition, health & aging | Issue 1/2018

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Abstract

Objectives

Frailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults.

Design

Cross-sectional study.

Setting

Cohort study that was part of the “National Center for Geriatrics and Gerontology–Study of Geriatric Syndromes.”

Participants

The study participants were 4133 older adults (mean age, 71.8 ± 5.4 years).

Measurements

We assessed serum IGF-1 levels and frailty status and collected demographic variables, including cognitive function, as covariates.

Results

Frailty and pre-frailty were present in 274 subjects (7%) and 1930 subjects (47%), respectively. Subjects were divided into four groups based on quartiles of IGF-1 levels. Multinomial logistic analysis showed that the lowest group had significant odds of pre-frailty (crude model: odds ratio [OR] 1.58, 95% confidence interval [CI] 1.30–1.90, p <.001; adjusted model: OR 1.38, 95% CI 1.13–1.68, p =.002) and frailty (crude model: OR 3.42, 95% CI 2.38-4.92, p <.001; adjusted model: OR 1.54, 95% CI 1.02–2.32, p =.039), compared with the highest group.

Conclusion

Lower serum IGF-1 levels were independently related with frailty in older adults.
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Metadata
Title
Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults
Authors
Takehiko Doi
H. Makizako
K. Tsutsumimoto
R. Hotta
S. Nakakubo
K. Makino
T. Suzuki
H. Shimada
Publication date
01-01-2018
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 1/2018
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-017-0916-1

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