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BMC Geriatrics
Published in: BMC Geriatrics 1/2018

Open Access 01-12-2018 | Research article

Association between cognitive function and life-space mobility in older adults: results from the FRéLE longitudinal study

Authors: François Béland, Dominic Julien, Nathalie Bier, Johanne Desrosiers, Marie-Jeanne Kergoat, Louise Demers

Published in: BMC Geriatrics | Issue 1/2018

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Abstract

Background

Cross-sectional and longitudinal studies show conflicting results regarding the association between cognition and life-space mobility, and little is known regarding the mediators and moderators of the association.
The aim of this study was to investigate the association between cognition and life-space mobility in older adults, as well as the intervening variables modifying the relationship.

Methods

Community-dwelling older adults aged 65 years and older (N = 1643) were assessed at three time points over a period of 2 years. Growth mixture models with mediation and moderation analysis were utilised to investigate association between cognitive function and life-space mobility. The potential mediators and moderators were depressive symptoms, locus of control, gait speed and grip strength. Analysis was controlled for age, sex, education, annual income, number of chronic illnesses, and living site.

Results

The direct association between initial scores of cognitive function and life-space was mediated by initial scores of depressive symptoms and gait speed, and moderated by initial scores of grip strength. No direct association between change in cognitive function and change in life-space mobility was found; the scores were mediated by change in depressive symptoms.

Conclusions

We conclude that the relationship between change in cognitive function and life-space mobility in older adults is not well-defined over an observation period of 2 years.
Appendix
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Literature
1.
Baker PS, Bodner EV, Allman RM. Measuring life-space mobility in community-dwelling older adults. J Am Geriatr Soc. 2003;51(11):1610–4.CrossRefPubMed
2.
Xue Q-L, Fried LP, Glass TA, Laffan A, Chaves PH. Life-space constriction, development of frailty, and the competing risk of mortality: the Women's health and aging study I. Am J Epidemiol. 2007;167(2):240–8.CrossRefPubMed
3.
Webber SC, Porter MM, Menec VH. Mobility in older adults: a comprehensive framework. The Gerontologist. 2010;50(4):443–50.CrossRefPubMed
4.
Wettstein M, Wahl HW, Shoval N, Oswald F, Voss E, Seidl U, Frolich L, Auslander G, Heinik J, Landau R. Out-of-home behavior and cognitive impairment in older adults: findings of the SenTra project. J Appl Gerontol. 2015;34(1):3–25.CrossRefPubMed
5.
O'connor ML, Edwards JD, Wadley VG, Crowe M. Changes in mobility among older adults with psychometrically defined mild cognitive impairment. J Gerontol B Psychol Sci Soc Sci. 2010;65((3):306–16.CrossRef
6.
Ball K, Owsley C. Increasing mobility and reducing accidents of older drivers. In: Schaie KW, Pietrucha M, editors. Mobility and transportation in the elderly. New York: Springer Publishing Company, Inc.; 2000. p. 213–51.
7.
Barnes LL, Wilson RS, Bienias JL, Mendes de Leon CF, Kim H-JN, Buchman AS, Bennett DA. Correlates of life space in a volunteer cohort of older adults. Exp Aging Res. 2007;33(1):77–93.CrossRefPubMed
8.
Peel C, Sawyer Baker P, Roth DL, Brown CJ, Brodner EV, Allman RM. Assessing mobility in older adults: the UAB study of aging life-space assessment. Phys Ther. 2005;85(10):1008–119.PubMed
9.
Sartori AC, Wadley VG, Clay OJ, Parisi JM, Rebok GW, Crowe M. The relationship between cognitive function and life space: the potential role of personal control beliefs. PsycholAging. 2012;27(2):364–74.
10.
Rantakokko M, Iwarsson S, Portegijs E, Viljanen A, Rantanen T. Associations between environmental characteristics and life-space mobility in community-dwelling older people. J Aging Health. 2015;27(4):606–21.CrossRefPubMed
11.
Al Snih S, Peek KM, Sawyer P, Markides KS, Allman RM, Ottenbacher KJ. Life-space mobility in Mexican Americans aged 75 and older. J Am Geriatr Soc. 2012;60(3):532–7.CrossRefPubMedCentralPubMed
12.
Curcio C-L, Alvarado BE, Gomez F, Guerra R, Guralnik J, Zunzunegui MV. Life-space assessment scale to assess mobility: validation in Latin American older women and men. Aging Clin Exp Res. 2013;25(5):553–60.CrossRefPubMed
13.
Silberschmidt S, Kumar A, Raji MM, Markides K, Ottenbacher KJ, Al Snih S: Life-space mobility and cognitive decline among Mexican Americans aged 75 years and older. J Am Geriatr Soc 2017:Epub ahead of print.
14.
Allman RM, Baker PS, Maisiak RM, Sims RV, Roseman JM. Racial similarities and differences in predictors of mobility change over eighteen months. J Gen Intern Med. 2004;19(11):1118–26.CrossRefPubMedCentralPubMed
15.
Poranen-Clark T, von Bonsdorff MB, Rantakokko M, Portegijs E, Eronen J, Kauppinen M, Eriksson JG, Rantanen T, Viljanen A: Executive function and life-space mobility in old age. Aging Clin Exp Res 2017:Epub ahead of print.
16.
Shah RC, Maitra K, Barnes LL, James BD, Leurgans S, Bennett DA. Relation of driving status to incident life space constriction in community-dwelling older persons: a prospective cohort study. J Gerontol A: Biomed Sci Med Sci. 2012;67(9):984–9.CrossRef
17.
Baron RM, Kenny DA. The moderator–mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.CrossRefPubMed
18.
Atkinson HH, Rapp SR, Williamson JD, Lovato J, Absher JR, Gass M, Henderson VW, Johnson KC, Kostis JB, Sink KM. The relationship between cognitive function and physical performance in older women: results from the women’s health initiative memory study. J Gerontol A Biomed Sci Med Sci. 2009;65((3):300–6.
19.
Watson N, Rosano C, Boudreau R, Simonsick E, Ferrucci L, Sutton-Tyrrell K, Hardy S, Atkinson H, Yaffe K, Satterfield S. Executive function, memory, and gait speed decline in well-functioning older adults. J Gerontol A Biomed Sci Med Sci. 2010;65((10):1093–100.CrossRef
20.
Yaffe K, Blackwell T, Gore R, Sands L, Reus V, Browner WS. Depressive symptoms and cognitive decline in nondemented elderly women: a prospective study. Arch Gen Psychiatry. 1999;56(5):425–30.CrossRefPubMed
21.
Galand C, Béland F, Fletcher J. FRéLE team: FRéLE : une étude québécoise sur la fragilité [FRéLE: a study on fraily in Quebec]. In: Béland F, Michel H, editors. La fragilité des personnes âgées: définitions, controverses et perspectives d’action [Fraily in older adults: definitions, controversies, and perspectives of action]. Rennes: Presses de l’EHESP; 2013. p. 177–204.
22.
Muthén LK, Muthén BO: Mplus User’s guide, 7th edition edn. Los Angeles, CA: Muthén & Muthén; 1998-2017.
23.
Provencher V, Béland F, Demers L, Desrosiers J, Bier N, Avila-Funes JA, Galand C, Julien D, Fletcher J, Trottier L, et al. Are frailty components associated with disability in specific activities of daily living in community-dwelling older adults? A multicenter Canadian study. Arch Gerontol Geriatr. 2017;73:187–94.CrossRefPubMed
24.
Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.CrossRefPubMed
25.
Folstein MF, Folstein SE, McHugh PR. “mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.CrossRefPubMed
26.
Yesavage JA, Sheikh JI. 9/geriatric depression scale (GDS) recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1–2):165–73.CrossRef
27.
Pearlin LI, Menaghan EG, Lieberman MA, Mullan JT. The stress process. J Health Soc Behav. 1981:337–56.CrossRefPubMed
28.
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85–94.CrossRefPubMed
29.
Fess EE. Grip strength. In: Casanova JS, editor. Clinical assessment recommendations. 2nd ed. Chicago: American Society of Hand Therapist; 1992. p. 41–5.
30.
Groll DL, To T, Bombardier C, Wright JG. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol. 2005;58(6):595–602.CrossRefPubMed
31.
Muthén B, Asparouhov T. Causal effects in mediation modeling: an introduction with applications to latent variables. Struct Equ Model Multidiscip J. 2015;22(1):12–23.CrossRef
32.
Muthén B, Asparouhov T, Hunter AM, Leuchter AF. Growth modeling with nonignorable dropout: alternative analyses of the STAR* D antidepressant trial. Psychol Methods. 2011;16(1):17–33.CrossRefPubMedCentralPubMed
33.
Demirtas H, Schafer JL. On the performance of random-coefficient pattern-mixture models for non-ignorable drop-out. Stat Med. 2003;22(16):2553–75.CrossRefPubMed
34.
Cheong J, MacKinnon DP, Khoo ST. Investigation of mediational processes using parallel process latent growth curve modeling. Struct Equ Model. 2003;10(2):238–62.CrossRef
35.
MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V. A comparison of methods to test mediation and other intervening variable effects. Psychol Methods. 2002;7(1):83.CrossRefPubMedCentralPubMed
36.
Preacher KJ, Rucker DD, Hayes AF. Addressing moderated mediation hypotheses: theory, methods, and prescriptions. Multivar Behav Res. 2007;42(1):185–227.CrossRef
37.
Hayes AF. An index and test of linear moderated mediation. Multivar Behav Res. 2015;50(1):1–22.CrossRef
38.
Chmura Kraemer H, Kiernan M, Essex M, Kupfer DJ. How and why criteria defining moderators and mediators differ between the Baron & Kenny and MacArthur approaches. Health Psychol. 2008;27(2S):S101.CrossRef
39.
von Soest T, Hagtvet KA. Mediation analysis in a latent growth curve modeling framework. Struct Equ Model. 2011;18(2):289–314.CrossRef
40.
Holland PW, Rubin DB. Causal inference in retrospective studies. ETS Res Rep Ser. 1987;1987(1):203–31.CrossRef
41.
Luo W, Lee K, Koh ICH. Do competitive performance goals and cooperative social goals conflict? A latent interaction analysis. Learn Individ Differ. 2015;39:186–92.CrossRef
42.
Gardner P. The role of social engagement and identity in community mobility among older adults aging in place. Disabil Rehabil. 2014;36(15):1249–57.CrossRefPubMed
43.
Pinquart M, Sorensen S. Influences on loneliness in older adults: a meta-analysis. Basic Appl Soc Psychol. 2001;23(4):245–66.CrossRef
44.
Stav WB, Hallenen T, Lane J, Arbesman M. Systematic review of occupational engagement and health outcomes among community-dwelling older adults. Am J Occup Ther. 2012;66(3):301–10.CrossRefPubMed
45.
Infurna FJ, Grimm KJ. The use of growth mixture modeling for studying resilience to major life stressors in adulthood and old age: lessons for class size and identification and model selection. J Gerontol B. 2017;73(1):148–59.CrossRef
46.
Kuh D, Ben-Shlomo Y. A life course approach to chronic disease epidemiology. 2nd ed. Oxford: Oxford University Press; 2004.CrossRef
Metadata
Title
Association between cognitive function and life-space mobility in older adults: results from the FRéLE longitudinal study
Authors
François Béland
Dominic Julien
Nathalie Bier
Johanne Desrosiers
Marie-Jeanne Kergoat
Louise Demers
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2018
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-018-0908-y

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