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Rheumatology International
Published in: Rheumatology International 10/2011

01-10-2011 | Original Article

Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom

Authors: Anant M. Ghelani, Ash Samanta, Adrian C. Jones, Sarabjit S. Mastana

Published in: Rheumatology International | Issue 10/2011

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Abstract

Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT1, GSTM1 and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R–R (OR = 3.16, CI 1.20–9.26, P < 0.05), A2M 1–1 (OR = 2.09, CI 1.21–3.64, P < 0.05) and GST T1null (OR = 1.97, CI 1.07–3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B–B genotype (OR = 2.08, CI 1.23–3.52, P < 0.05), A2M 2–2 genotype (OR = 3.99, CI 1.19–17.18, P < 0.05), and GST T1null genotype (OR = 2.81, CI 1.40–5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA.
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Metadata
Title
Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom
Authors
Anant M. Ghelani
Ash Samanta
Adrian C. Jones
Sarabjit S. Mastana
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 10/2011
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-010-1478-2

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