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Open Access 01-12-2017 | Research article

Assessment of gray and white matter structural alterations in migraineurs without aura

Authors: Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu, Xiaoxia Du

Published in: The Journal of Headache and Pain | Issue 1/2017

Abstract

Background

Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function of the human brain is related to its structure, we further investigated white and gray matter structural alterations in migraineurs.

Methods

In current study, we used surface-based morphometry, voxel-based morphometry and diffusion tensor imaging analyses to detect structural alterations of the white matter and gray matter in 32 migraineurs without aura compared with 32 age- and gender-matched healthy controls.

Results

We found that migraineurs without aura exhibited significantly increased gray matter volume in the bilateral cerebellar culmen, increased cortical thickness in the lateral occipital-temporal cortex, decreased cortical thickness in the right insula, increased gyrification index in left postcentral gyrus, superior parietal lobule and right lateral occipital cortex, and decreased gyrification index in the left rostral middle frontal gyrus compared with controls. No significant change in white matter microstructure was found in DTI analyses.

Conclusion

The significantly altered gray matter brain regions were known to be associated with sensory discrimination of pain, multi-sensory integration and nociceptive information processing and were consistent with our previous fMRI study, and may be involved in the pathological mechanism of migraine without aura.

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Title: Assessment of gray and white matter structural alterations in migraineurs without aura
Authors: Jilei Zhang
Yi-Lan Wu
Jingjing Su
Qian Yao
Mengxing Wang
Ge-Fei Li
Rong Zhao
Yan-Hui Shi
Ying Zhao
Qiting Zhang
Haifeng Lu
Shuai Xu
Zhaoxia Qin
Guo-Hong Cui
Jianqi Li
Jian-Ren Liu
Xiaoxia Du
Publication date: 01-12-2017
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-017-0783-5

At a glance: The STEP trials

Springer Medicine

Assessment of gray and white matter structural alterations in migraineurs without aura

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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