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European Journal of Nuclear Medicine and Molecular Imaging

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01-12-2012 | Editorial Commentary

Assessing the activity of cardiac sympathetic innervation with a novel PET tracer

Author: Ornella Rimoldi

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2012

Excerpt

When he was awarded the Nobel Prize in 1970, Ulf von Euler described cardiac adrenergic neurotransmission as follows: “Section of the adrenergic nerves to the heart and some other organs and subsequent degeneration caused the noradrenaline content to fall to very low values, or to disappear, which also indicated that it was normally bound to the nerves in the organs” … “With the aid of radioactively labelled noradrenaline it could be shown that uptake of transmitter occurred in the particles concomitantly with the release”. His seminal work in 1946 was the foundation for the noninvasive study of cardiac sympathetic activity [1]. …

Euler UV. Adrenergic neurotransmitter functions. 12 December 1970. Stockholm: Nobel Lecture. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1970/euler-lecture.pdf. Accessed 3 Oct 2012.

Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1986;73:615–21. doi:10.1161/01.cir.73.4.615.PubMedCrossRef

Böhm M, La Rosée K, Schwinger RHG, Erdmann E. Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol. 1995;25:146–53.PubMedCrossRef

Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212–21.PubMedCrossRef

John AS, Mongillo M, Depre C, Khan MT, Rimoldi OE, Pepper JR, et al. Pre- and post-synaptic sympathetic function in human hibernating myocardium. Eur J Nucl Med Mol Imaging. 2007;34:1973–80.PubMedCrossRef

Kies P, Wichter T, Schafers M, Paul M, Schafers KP, Eckardt L, et al. Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation. 2004;110:3017–22. doi:10.1161/01.CIR.0000146920.35020.44.PubMedCrossRef

Schafers M, Dutka D, Rhodes CG, Lammertsma AA, Hermansen F, Schober O, et al. Myocardial presynaptic and postsynaptic autonomic dysfunction in hypertrophic cardiomyopathy. Circ Res. 1998;82:57–62.PubMedCrossRef

Carrio I. Cardiac neurotransmission imaging. J Nucl Med. 2001;42:1062–76.PubMed

Goldstein DS, Eisenhofer G, Dunn BB, Armando I, Lenders J, Grossman E, et al. Positron emission tomographic imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: initial findings in humans. J Am Coll Cardiol. 1993;22:1961–71.PubMedCrossRef

10.

Yu M, Bozek J, Lamoy M, Kagan M, Benites P, Onthank D, et al. LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment. Eur J Nucl Med Mol Imaging. 2012. doi:10.1007/s00259-012-2204-y.

11.

Yu M, Bozek J, Lamoy M, Guaraldi M, Silva P, Kagan M, et al. Evaluation of LMI1195, a novel 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models. Circ Cardiovasc Imaging. 2011;4:435–43.PubMedCrossRef

12.

Bulow HP, Stahl F, Lauer B, Nekolla SG, Schuler G, Schwaiger M, et al. Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction. Nucl Med Commun. 2003;24:233–9.PubMedCrossRef

13.

Calkins H, Allman K, Bolling S, Kirsch M, Wieland D, Morady F, et al. Correlation between scintigraphic evidence of regional sympathetic neuronal dysfunction and ventricular refractoriness in the human heart. Circulation. 1993;88:172–9.PubMedCrossRef

14.

Goldberger JJ, Buxton AE, Cain M, Costantini O, Exner DV, Knight BP, et al. Risk stratification for arrhythmic sudden cardiac death. Circulation. 2011;123:2423–30.PubMedCrossRef

Title: Assessing the activity of cardiac sympathetic innervation with a novel PET tracer
Author: Ornella Rimoldi
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2264-z

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Assessing the activity of cardiac sympathetic innervation with a novel PET tracer

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