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Critical Care
Published in: Critical Care 1/2020

01-12-2020 | Aspergillus Fumigatus | Research Letter

Impact of negative air pressure in ICU rooms on the risk of pulmonary aspergillosis in COVID-19 patients

Authors: Philippe Ichai, Faouzi Saliba, Patricia Baune, Asma Daoud, Audrey Coilly, Didier Samuel

Published in: Critical Care | Issue 1/2020

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Excerpt

From the start of the COVID-19 epidemic, one recommendation regarding the intensive care management of COVID-19 patients concerned the infrastructure in intensive care units (ICU) and particularly the air pressure system in ICU rooms [1]. Under normal circumstances and mainly in ICUs hosting immunocompromised patients, ICU rooms are equipped with positive air room pressure in order to protect patients against infections from the surrounding environment and particularly those due to Aspergillus fumigatus (AF). This link between positive pressure rooms and a reduction in Aspergillus infection rates has been demonstrated during several studies [2]. However, these studies included numerous other associated preventive measures. The relationship between the fungal levels in the air of neutral pressure rooms and those in positive pressure rooms has not been established [3]. …
Literature
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Phua J, Weng L, Ling L, Egi M, Lim CM, Divatia JV, et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506–17.CrossRef
2.
Humphreys H. Positive-pressure isolation and the prevention of invasive aspergillosis. What is the evidence? J Hosp Infect. 2004;56(2):93–100 quiz 63.CrossRef
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Ryan L, O'Mara N, Tansey S, Slattery T, Hanahoe B, Vellinga A, et al. A 2-year comparative study of mold and bacterial counts in air samples from neutral and positive pressure rooms in 2 tertiary care hospitals. Am J Infect Control. 2018;46(5):590–3.CrossRef
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Alanio A, Delliere S, Fodil S, Bretagne S, Megarbane B. Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19. Lancet Respir Med. 2020;8(6):e48–e9.CrossRef
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Koehler P, Cornely OA, Bottiger BW, Dusse F, Eichenauer DA, Fuchs F, et al. COVID-19 associated pulmonary aspergillosis. Mycoses. 2020;63(6):528–34.CrossRef
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Thevissen K, Jacobs C, Holtappels M, Toda M, Verweij P, Wauters J. International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe. Crit Care. 2020;24(1):84.CrossRef
Metadata
Title
Impact of negative air pressure in ICU rooms on the risk of pulmonary aspergillosis in COVID-19 patients
Authors
Philippe Ichai
Faouzi Saliba
Patricia Baune
Asma Daoud
Audrey Coilly
Didier Samuel
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03221-w

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