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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2019 | Osteoarthrosis | Research article

Prospective randomized controlled study on improving sleep quality and impact of zolpidem after total hip arthroplasty

Authors: Hirose Shakya, Duan Wang, Kai Zhou, Ze-Yu Luo, Suraj Dahal, Zong-Ke Zhou

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Abstract

Background

Total hip arthroplasty (THA) is a proven surgical option for patients with end-stage osteoarthritis in terms of improved function and pain relief. A prospective study was conducted to examine and evaluate the effect and impact of zolpidem postoperatively on the sleep quality, pain alleviation, and quality of life of patients who underwent total hip arthroplasty.

Methods

A total of 160 patients was randomized 1:1 to receive either zolpidem or placebo 2 days preoperative to 5 days postoperatively. Pain scores using visual analog scale (VAS), sleep quality using Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale, quality of life using QoR-40, and Hip disability and Osteoarthritis Outcome Score were recorded. The total amount of opioid analgesics and antiemetics taken was recorded as well.

Results

Patients in the intervention group had higher VAS score and took less analgesic and antiemetic. Moreover, the study demonstrated that QoR-40 was higher and Hip disability and Osteoarthritis Outcome Score had relatively lower mean value (P < 0.05) in the treatment group. Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were also lower in the treatment group (P < 0.05).

Conclusion

Patients taking zolpidem achieved greater improvement in the quality of life and reported better satisfaction. The study demonstrated zolpidem 10 mg can improve sleep quality effectively, relieve pain, increase early range of motion and muscle strength, reduce the perioperative anxiety and depression, and improve perioperative experience and satisfaction, thereby reducing the hospital stay and medical costs and promote the rapid recovery and quality of life.

Trial registration

The trial was registered on Chinese Clinical Trial Registry, ChiCTR-IOR-16007861.

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Title: Prospective randomized controlled study on improving sleep quality and impact of zolpidem after total hip arthroplasty
Authors: Hirose Shakya
Duan Wang
Kai Zhou
Ze-Yu Luo
Suraj Dahal
Zong-Ke Zhou
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Osteoarthrosis
Mood Disorders
Osteoarthrosis
Affective Disorder
Anxiety
Hip-TEP
Hip-TEP
Zolpidem
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1327-2

At a glance: The STEP trials

Springer Medicine

Prospective randomized controlled study on improving sleep quality and impact of zolpidem after total hip arthroplasty

Abstract

Background

Methods

Results

Conclusion

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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