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The Journal of Headache and Pain

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Open Access 01-12-2015 | Research article

Resting state brain activity in patients with migraine: a magnetoencephalography study

Authors: Hongxing Liu, Huaiting Ge, Jing Xiang, Ailiang Miao, Lu Tang, Ting Wu, Qiqi Chen, Lu Yang, Xiaoshan Wang

Published in: The Journal of Headache and Pain | Issue 1/2015

Abstract

Background

Recent advances in migraine research have shown that the cerebral cortex serves a primary role in the pathogenesis of migraine. Since aberrant brain activity in migraine can be noninvasively detected with magnetoencephalography (MEG), The object of this study was to investigate the resting state cortical activity differences between migraineurs and controls and its related clinical characteristics.

Methods

Twenty-two subjects with an acute migraine and twenty-two age- and gender-matched controls were studied using MEG. MEG recordings were recorded 120 seconds during the headache attack. Analyze MEG signals from low (1–4 Hz) to high (200–1000 Hz)-frequency ranges.

Results

In comparison with the controls, brain activity in migraine subjects was significantly different from that of the controls both in two frequency ranges (55–90 Hz, p < 0.001) and (90–200 Hz, p < 0.004). But the power value showed no significantly differences between control and migraines in all frequency ranges (p > 0.05). All the clinical characteristics had no significant correlation with aberrant brain activity.

Conclusions

The results demonstrated that migraine subjects in resting state had significantly aberrant ictal brain activity that can be measured with neuromagnetic imaging techniques. The findings may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability with TMS and other medications in the future.

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Title: Resting state brain activity in patients with migraine: a magnetoencephalography study
Authors: Hongxing Liu
Huaiting Ge
Jing Xiang
Ailiang Miao
Lu Tang
Ting Wu
Qiqi Chen
Lu Yang
Xiaoshan Wang
Publication date: 01-12-2015
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-015-0525-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Resting state brain activity in patients with migraine: a magnetoencephalography study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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