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Pediatric Radiology

Published in:

01-05-2003 | Original Article

Volumetric localization of somatosensory cortex in children using synthetic aperture magnetometry

Authors: Jing Xiang, Stephanie Holowka, Rohit Sharma, Amrita Hunjan, Hiroshi Otsubo, Sylvester Chuang

Published in: Pediatric Radiology | Issue 5/2003

Abstract

Background

Magnetic signal from the human brain can be measured noninvasively by using magnetoencephalography (MEG).

Objective

This study was designed to localize and reconstruct the neuromagnetic activity in the somatosensory cortex in children

Materials and methods

Twenty children were studied using a 151-channel MEG system with electrical stimulation applied to median nerves. Data were analyzed using synthetic aperture magnetometry (SAM).

Results

A clear deflection (M1) was clearly identified in 18 children (90%, 18/20). Two frequency bands, 30–60 Hz and 60–120 Hz, were found to be related to somatosensory cortex. Magnetic activity was localized in the posterior bank of the central sulcus in 16 children. The extent of the reconstructed neuromagnetic activity of the left hemisphere was significantly larger than that of the right hemisphere (P<0.01).

Conclusion

Somatosensory cortex was accurately localized by using SAM. The extent of the reconstructed neuromagnetic activity suggested that the left hemisphere was the dominant side in the somatosensory system in children. We postulate that the volumetric characteristics of the reconstructed neuromagnetic activity are able to indicate the functionality of the brain.

Hari R, Joutsiniemi SL, Sarvas J (1988) Spatial resolution of neuromagnetic records: theoretical calculations in a spherical model. Electroencephalogr Clin Neurophysiol 71:64–72PubMed

Kakigi R, Hoshiyama M, Shimojo M, et al (2000) The somatosensory evoked magnetic fields. Prog Neurobiol 61:495–523CrossRefPubMed

Roberts T, Rowley H, Kucharczyk J (1995) Applications of magnetic source imaging to presurgical brain mapping. Neuroimaging Clin N Am 5:251-266PubMed

Otsubo H, Snead OC, III (2001) Magnetoencephalography and magnetic source imaging in children. J Child Neurol 16:227–235PubMed

Alberstone CD, Skirboll SL, Benzel EC, et al (2000) Magnetic source imaging and brain surgery: presurgical and intraoperative planning in 26 patients. J Neurosurg 92:79–90PubMed

Kawamura T, Nakasato N, Seki K, et al (1996) Neuromagnetic evidence of pre- and post-central cortical sources of somatosensory evoked responses. Electroencephalogr Clin Neurophysiol 100:44–50CrossRefPubMed

Xiang J, Hoshiyama M, Koyama S, et al (1997) Somatosensory evoked magnetic fields following passive finger movement. Brain Res Cogn Brain Res 6:73–82

Kamada K, Oshiro O, Takeuchi F, et al (1993) Identification of central sulcus by using somatosensory evoked magnetic fields and brain surface MR images: three dimensional projection analysis. J Neurol Sci 116:29–33PubMed

Orrison WW Jr (1999) Magnetic source imaging in stereotactic and functional neurosurgery. Stereotact Funct Neurosurg 72:89–94PubMed

10.

Nakasato N, Yoshimoto T (2000) Somatosensory, auditory, and visual evoked magnetic fields in patients with brain diseases. J Clin Neurophysiol 17:201–211PubMed

11.

Xiang J, Kakigi R, Hoshiyama M, et al (1997) Somatosensory evoked magnetic fields and potentials following passive toe movement in humans. Electroencephalogr Clin Neurophysiol 104:393–401

12.

Robinson SD, Vrba J (1999) Functional neuroimaging by synthetic aperture magnetometr (SAM). In: Yoshimoto T, Kotani M, Kuriki S (eds) Recent advances in biomagnetism, Tohoku Univsersity Press, Sendai, pp 302–305

13.

Xiang J, Wilson D, Otsubo H, et al (2001) Neuromagnetic spectral distribution of implicit processing of words. Neuroreport 12:3923–3927PubMed

14.

Hirata M, Kato A, Taniguchi M, et al (2002) Frequency-dependent spatial distribution of human somatosensory evoked neuromagnetic fields. Neurosci Lett 318:73–76CrossRefPubMed

15.

Roberts TP, Poeppel D, Rowley HA (1998) Magnetoencephalography and magnetic source imaging. Neuropsychiatry Neuropsychol Behav Neurol 11:49–64PubMed

16.

Hamzei F, Liepert J, Dettmers C, et al (2001) Structural and functional cortical abnormalities after upper limb amputation during childhood. Neuroreport 12:957–962PubMed

17.

Mogilner A, Grossman JA, Ribary U, et al (1993) Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc Natl Acad Sci U S A 90:3593–3597PubMed

18.

Pantev C, Lutkenhoner B (2000) Magnetoencephalographic studies of functional organization and plasticity of the human auditory cortex. J Clin Neurophysiol 17:130–142PubMed

19.

Vrba J, Betts K, Burbank M, et al (1993) Whole cortex, 64 channel SQUID biomagnetometer system. IEEE Trans Appl Suppl 3:1878–1882CrossRef

20.

Makela JP, Kirveskari E, Seppa M, et al (2001) Three-dimensional integration of brain anatomy and function to facilitate intraoperative navigation around the sensorimotor strip. Hum Brain Mapp 12:180–192PubMed

21.

Minassian BA, Otsubo H, Weiss S, et al (1999) Magnetoencephalographic localization in pediatric epilepsy surgery: comparison with invasive intracranial electroencephalography. Ann Neurol 46:627–633CrossRefPubMed

22.

Kamada K, Takeuchi F, Kuriki S, et al (1993) Functional neurosurgical simulation with brain surface magnetic resonance images and magnetoencephalography. Neurosurgery 33:269–272PubMed

23.

Hari R, Portin K, Kettenmann B, et al (1997) Right-hemisphere preponderance of responses to painful CO₂ stimulation of the human nasal mucosa. Pain 72:145–151CrossRefPubMed

24.

Elbert T, Flor H, Birbaumer N, et al (1994) Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. Neuroreport 5:2593–2597PubMed

25.

Elbert T, Sterr A, Flor H, et al (1997) Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans. Exp Brain Res 117:161–164CrossRefPubMed

26.

Hari R, Karhu J, Hamalainen M, et al (1993) Functional organization of the human first and second somatosensory cortices: a neuromagnetic study. Eur J Neurosci 5:724–734PubMed

27.

Papanicolaou AC, Simos PG, Breier JI, et al (2001) Brain plasticity for sensory and linguistic functions: a functional imaging study using magnetoencephalography with children and young adults. J Child Neurol 16:241–252PubMed

Title: Volumetric localization of somatosensory cortex in children using synthetic aperture magnetometry
Authors: Jing Xiang
Stephanie Holowka
Rohit Sharma
Amrita Hunjan
Hiroshi Otsubo
Sylvester Chuang
Publication date: 01-05-2003
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 5/2003
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-003-0883-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Volumetric localization of somatosensory cortex in children using synthetic aperture magnetometry

Abstract

Background

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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