Issue Special Issue 3/2012
Lupus 2012: New targets, new approaches
Content (64 Articles)
Follicular helper T Cells and the B cells they help
A Poholek, J-Y Choi, S Hernandez, J Weinstein, S Kim, V Bunin, J Odegard, L DiPlacido, J Craft
Longitudinal analysis of mRNA transcripts and plasma proteins to define a biomarker associated with lupus disease activity
M Olferiev, W-T Huang, KA Kirou, E Gkrouzman, D Lundsgaard, KS Frederiksen, J Fleckner, MK Crow
MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant
Y Deng, J Zhao, D Sakurai, KM Kaufman, JC Edberg, RP Kimberly, DL Kamen, GS Gilkeson, CO Jacob, RH Scofield, CD Langefeld, JA Kelly, ME Alarcón-Riquelme, JB Harley, TJ Vyse, BI Freedman, PM Gaffney, KM Sivils, JA James, TB Niewold, RM Cantor, W Chen, BH Hahn, EE Brown, BP Tsao
Differential DNA methylation associated with anti-dsDNA autoantibody production in systemic lupus erythematosus
SA Chung, J French, KE Taylor, E Elboudwarej, HL Quach, LF Barcellos, LA Criswell
Area-level socioeconomic status and variation in medication use among Medicaid enrollees with incident systemic lupus erythematosus, 2000 to 2004
CH Feldman, LT Hiraki, J Lui, GS Alarcón, MA Fischer, J Yazdany, KH Costenbader
SLE risk alleles and cell development and activation
SJ Kim, N Manjarrez Orduno, PK Gregersen, B Diamond
Serum chemokine levels predict flares of disease activity in two independent systemic lupus erythematosus cohorts
H Bilgic, T Koeuth, J Wilson, M Petri, E Baechler Gillespie
Major congenital anomalies in children born to women with systemic lupus erythematosus
E Vinet, CA Pineau, AE Clarke, M Kaouache, C Gordon, R Platt, S Bernatsky
Contemporary estimates of the risk of end-stage renal disease in the first decade of proliferative lupus nephritis
MM Ward, M Tektonidou
Impact of systemic lupus erythematosus organ damage on unemployment or disability from a population-based cohort
SS Lim, M Agan, CM Drenkard
Population-based study of preventable infections in hospitalized patients with systemic lupus erythematosus
CE Barber, C Barnabe, D Marshall, J Esdaile
Lung cancer in systemic lupus erythematosus
M Kale, R Ramsey-Goldman, S Bernatsky, MB Urowitz, D Gladman, PR Fortin, M Petri, E Yelin, S Manzi, S Edworthy, O Nived, S-C Bae, D Isenberg, A Rahman, JG Hanly, C Gordon, S Jacobsen, E Ginzler, DJ Wallace, GS Alarcón, MA Dooley, L Gottesman, K Steinsson, A Zoma, J-L Senécal, S Barr, G Sturfelt, L Dreyer, L Criswell, J Sibley, JL Lee, AE Clarke
Lymphoma risk in systemic lupus: effects of treatment versus disease activity
AE Clarke, S Bernatsky, KH Costenbader, MB Urowitz, DD Gladman, PR Fortin, M Petri, S Manzi, DA Isenberg, A Rahman, D Wallace, C Gordon, C Peschken, MA Dooley, EM Ginzler, C Aranow, SM Edworthy, O Nived, S Jacobsen, G Ruiz-Irastorza, E Yelin, SG Barr, L Criswell, G Sturfelt, L Dreyer, I Blanco, L Gottesman, CH Feldman, R Ramsey-Goldman
Usual source of care and geographic region are largest predictors of healthcare quality for incident lupus nephritis in US Medicaid recipients
J Yazdany, C Feldman, J Liu, MM Ward, MA Fischer, KH Costenbader
Neuropsychiatric events in SLE: determination of attribution and assessment of outcome
JG Hanly
Seafood consumption and persistent organic pollutants as triggers of autoimmunity among Gullah African Americans
DL Kamen, MM Peden-Adams, JE Vena, GS Gilkeson, TC Hulsey, L Moultrie, BE Stevens
Rising prevalence of systemic autoimmune rheumatic disease: increased awareness, increased disease or increased survival?
CA Peschken, CA Hitchon
Soluble E-selectin may predict progression of subclinical atherosclerosis, as measured by coronary artery calcium score and aorta calcium score, in women with systemic lupus erythematosus
A Lertratanakul, P Wu, A Dyer, W Pearce, G Kondos, D Edmundowicz, J Carr, R Ramsey-Goldman
Serum α-chlorofatty acid as a biomarker for baseline subclinical cardiovascular disease in systemic lupus erythematosus
MA Mahieu, C Guild, CJ Albert, G Kondos, J Carr, D Edmundowicz, DA Ford, R Ramsey-Goldman
Differing environmental risk factors for membranous versus proliferative lupus nephritis
MA Dooley, CG Parks, GS Cooper
B cells at the adaptive-innate immune system interface in SLE
JH Anolik, A Palanichamy, J Bauer, J Barnard, J Biear, R Dedrick, I Sanz, J Liesveld, E Baechler
In situ cognate interactions between T-follicular helper cells and B cells characterize severe tubulointerstitial inflammation in human lupus nephritis
MR Clark, M Giger, Y Jiang, V Liarski
SLE patients and autoantibody-positive healthy individuals display unique cytokine profiles: shared features of inflammation as well as select features of immunosuppression in autoantibody-positive healthy individuals
LL Ritterhouse, HT Maecker, CG Fathman, JT Merrill, JM Guthridge, JA James
Regulatory natural autoantibodies suppress inflammation and SLE disease activity
GJ Silverman, J Vas, C Grönwall
Genetic polymorphisms leading to altered T-cell and dendritic cell function cooperate to produce expansion of proinflammatory T-cell subsets in NZB c1 congenic mice
N Talaei, C Landolt-Marticorena, B Noamani, E Pau, N-H Chang, JE Wither
Abstract withdrawn
Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity
JC Crispín
Spontaneous aggregation of the anti-viral MAVS protein in systemic lupus erythematosus: a possible cause of excessive type I interferon production
PL Cohen, B Hilliard, W-H Shao
IRF5 expression profiling in SLE patients: new leads to a pathogenic signature?
BJ Barnes, RC Stone, P Du, D Feng
Role of MIF gene polymorphisms in systemic lupus erythematosus and prospects for therapeutic intervention
R Bucala
Interplay of neutrophils and type I interferons in the development of end-organ damage in SLE
MJ Kaplan
Microparticles as autoantigens in human and murine lupus
A Ullal, DS Pisetsky
Innate sensors for nucleic acids and lupus pathogenesis
AN Theofilopoulos, R Gonzalez-Quintial, Y-T Koh, R Baccala, DH Kono
Evaluating the B-cell C3d:CR2 innate-adaptive immune interaction as a therapeutic target in lupus
VM Holers, JM Thurman, JP Hannan, L Kulik
PROMISSE: progress in understanding pregnancy complications in patients with SLE
JE Salmon
Complement deficiencies and susceptibility to systemic lupus erythematosus revisited
KB Elkon, DM Santer, A Wiedeman
Connecting the molecular dots from inaccessible antigen to organ injury in the pathogenesis of cardiac manifestations of neonatal lupus
JP Buyon
Skin-antigen specific antibodies are detected in UV irradiation and TLR7 agonist induced lupus-like disease in autoimmune prone NOD mice and in pediatric SLE
M Ghoreishi, L Tucker, JP Dutz
Renal flare as a biomarker of incident and progressive chronic kidney disease in patients with lupus nephritis
S Parikh, A McKinley, BH Rovin
Cytokine profiles of lupus patients with or without nephritis
BH Rovin, H Song, CL Hines, X Zhang
Which lupus trial endpoints best reflect clinical judgment or biomarker improvement?
A Thanou, M Munroe, S Kamp, F Carthen, JA James, JT Merrill
'MiLES' population-based survey of the incidence and prevalence of systemic lupus erythematosus in Southeastern Michigan
EC Somers, W Marder, P Cagnoli, EE Lewis, P DeGuire, C Gordon, CG Helmick, L Wang, JJ Wing, JP Dhar, J Liesen, WJ McCune
Sociodemographic characteristics of SLE patients in a large metropolitan area with a high Afro-Caribbean population
J Cabas-Vargas, NM Patel, J Cohen, EM Ginzler
High score on PREDICTS is associated with 10-fold increased odds for the progression of subclinical atherosclerosis in SLE
M McMahon, Lori Sahakian, J Grossman, B Skaggs, J Fitzgerald, C Charles-Schoeman, N Ragavendra, A Gorn, G Karpouzas, M Weisman, D Wallace, B Hahn
Thinking toward improved treatments of systemic lupus erythematosus
BH Hahn, J Grossman, B Skaggs, E Lourenco, M Wong
Risk of pulmonary embolism and deep vein thrombosis in systemic lupus erythematosus: a population-based cohort study
JA Aviña-Zubieta, D Lacaille, EC Sayre, J Kopec, HK Choi, JM Esdaile
Poor methodological reporting in lupus clinical trials found in Cochrane reviews
CH Goldsmith
Development validation and reliability of the Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50
Z Touma, DD Gladman, MB Urowitz
Clinical and immunological response to pneumococcal vaccination in pediatric systemic lupus erythematosus
D Rigdon, AC Gotte, MG Punaro, TB Wright
Role of anti-Ro autoantibodies in systemic lupus erythematosus patients with recurrent myositis
S Umer, S Hayat, G Caldito, SM Berney
Variation in renal biopsy and medication prescribing practices among pediatric Medicaid patients with lupus nephritis prior to end-stage renal disease in the US, 2000 to 2004
LT Hiraki, CH Feldman, J Liu, GS Alarcón, MA Fischer, WC Winkelmayer, KH Costenbader
Hospitalizations in patients with systemic lupus erythematosus: updated analyses from 2006 to 2011
K Chan, A Dekis, AE Clarke, CA Pineau, E Vinet, E Nashi, S Bernatsky
B-cell receptor signaling studies in patients with lupus: preliminary results
M Faludi, A Mao, E Vinet, A Clarke, C Pineau, S Bernatsky, E Nashi
Lupus cardiomyopathy: a reversible form of left ventricular dysfunction
ML Ishimori, M Agarwal, RK Ng, LD Nugent, DJ Wallace, RJ Siegel, MH Weisman
Prevalence of angina in patients with systemic lupus erythematosus
ML Ishimori, NJ Gal, A Rogatko, DS Berman, A Wilson, DJ Wallace, NB Merz, MH Weisman
Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients
MA Jensen, KC Patterson, AA Kumar, M Kumabe, BS Franek, TB Niewold
Nonlymphoma hematological malignancies in systemic lupus erythematosus
M Lu, R Ramsey-Goldman, S Bernatsky, M Petri, S Manzi, MB Urowitz, D Gladman, PR Fortin, E Ginzler, E Yelin, S-C Bae, DJ Wallace, S Jacobsen, MA Dooley, CA Peschken, GS Alarcón, O Nived, L Gottesman, L Criswell, G Sturfelt, L Dreyer, JL Lee, AE Clarke