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01-09-2021 | Arterial Occlusive Disease | Original Article

Relationship between dry mouth and hypertension

Authors: Makiko Kawamoto, Shin-ichi Yamada, Takahiko Gibo, Ryo Kajihara, Sachiho Nagashio, Hirokazu Tanaka, Junichi Yajima, Atsushi Takizawa, Eiji Kondo, Hironori Sakai, Tomoki Kaneko, Takeshi Uehara, Hiroshi Kurita

Published in: Clinical Oral Investigations | Issue 9/2021

Abstract

Objectives

Salivary dysfunction, such as reduced salivary flow and an altered salivary composition, is caused by several diseases, medical conditions, and medications. The purpose of the present study was to clarify the relationship between hypertension and morphological changes in the submandibular glands.

Materials and methods

An epidemiological study was conducted to elucidate the relationship between hypertension and dry mouth. The effects of hypertension on morphological changes and the intima thickness of arteries in the submandibular glands were histopathologically investigated.

Results

Among 1933 subjects in the epidemiological study, 155 (8.0%) had dry mouth. A multivariate analysis revealed that dry mouth correlated with age (p < 0.001), sex (p < 0.001), and hypertension (p < 0.05). No significant differences were observed in the size of the submandibular glands between patients with or without hypertension. The average area of acinar cells was smaller in patients with than in those without hypertension (0.366 ± 0.153 vs. 0.465 ± 0.178, p < 0.05). The arteriosclerotic index was significantly higher in patients with than in those without hypertension (0.304 ± 0.034 vs 0.475 ± 0.053, p < 0.05).

Conclusions

Hypertension may contribute to the degeneration of the submandibular glands by decreasing the number of acinar cells and promoting fatty infiltration and stenosis of the arteries.

Clinical relevance

There may be a correlation between hypertension and the degeneration of the submandibular glands by decreasing the number of acinar cells and promoting fatty infiltration and stenosis of the arteries.

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Title: Relationship between dry mouth and hypertension
Authors: Makiko Kawamoto
Shin-ichi Yamada
Takahiko Gibo
Ryo Kajihara
Sachiho Nagashio
Hirokazu Tanaka
Junichi Yajima
Atsushi Takizawa
Eiji Kondo
Hironori Sakai
Tomoki Kaneko
Takeshi Uehara
Hiroshi Kurita
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Arterial Occlusive Disease
Hypertension
Hypertension
Published in: Clinical Oral Investigations / Issue 9/2021
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-021-03829-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between dry mouth and hypertension

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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