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Malaria Journal
Published in: Malaria Journal 1/2010

Open Access 01-12-2010 | Research

Artemisone effective against murine cerebral malaria

Authors: Judith H Waknine-Grinberg, Nicholas Hunt, Annael Bentura-Marciano, James A McQuillan, Ho-Wai Chan, Wing-Chi Chan, Yechezkel Barenholz, Richard K Haynes, Jacob Golenser

Published in: Malaria Journal | Issue 1/2010

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Abstract

Background

Artemisinins are the newest class of drug approved for malaria treatment. Due to their unique mechanism of action, rapid effect on Plasmodium, and high efficacy in vivo, artemisinins have become essential components of malaria treatment. Administration of artemisinin derivatives in combination with other anti-plasmodials has become the first-line treatment for uncomplicated falciparum malaria. However, their efficiency in cases of cerebral malaria (CM) remains to be determined.

Methods

The efficacy of several artemisinin derivatives for treatment of experimental CM was evaluated in ICR or C57BL/6 mice infected by Plasmodium berghei ANKA. Both mouse strains serve as murine models for CM.

Results

Artemisone was the most efficient drug tested, and could prevent death even when administered at relatively late stages of cerebral pathogenesis. No parasite resistance to artemisone was detected in recrudescence. Co-administration of artemisone together with chloroquine was more effective than monotherapy with either drug, and led to complete cure. Artemiside was even more effective than artemisone, but this substance has yet to be submitted to preclinical toxicological evaluation.

Conclusions

Altogether, the results support the use of artemisone for combined therapy of CM.
Appendix
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Metadata
Title
Artemisone effective against murine cerebral malaria
Authors
Judith H Waknine-Grinberg
Nicholas Hunt
Annael Bentura-Marciano
James A McQuillan
Ho-Wai Chan
Wing-Chi Chan
Yechezkel Barenholz
Richard K Haynes
Jacob Golenser
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2010
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-9-227

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