Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
The Cerebellum

Open Access 20-01-2024 | Aphasia | Research

Cerebellar-Induced Aphasia After Stroke: Evidence for the “Linguistic Cerebellum”

Authors: Djaina Satoer, Peter J. Koudstaal, Evy Visch-Brink, Ruben S. van der Giessen

Published in: The Cerebellum

Login to get access

Abstract

The cerebellum is traditionally known to subserve motor functions. However, for several decades, the concept of the “cerebellar cognitive affective syndrome” has evolved. Studies in healthy participants and patients have confirmed the cerebellar role in language. The exact involvement of the cerebellum regarding cerebellar aphasia remains uncertain. We included 43 cerebellar stroke patients who were tested at 3 months post-onset with the Boston Naming Test (BNT), the Token Test (TT), and the Diagnostic Instrument for Mild Aphasia (DIMA). Lesion side (left/right) and volume (cm3) were investigated. Patients significantly deviated on the following: BNT (p<0.001), TT (p<0.05), DIMA subtests: sentences repetition (p=0.001), semantic odd-picture-out (p<0.05), sentence completion (p<0.05) without an effect of lesion location (left/right) or volume (cm3) (p>0.05). Our clinical study confirms a non-lateralized cerebellar aphasia post-stroke, characterized by impairments in word retrieval, phonology, semantics, and syntax resembling cerebral-induced aphasia. The integral cerebellum appears to interact with eloquent cortico-subcortical language areas.
Literature
1.
Manto M, Bower JM, Conforto AB, Delgado-García JM, da Guarda SN, Gerwig M, et al. Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement. Cerebellum. 2012;11(2):457–87.PubMedPubMedCentralCrossRef
2.
Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121(Pt 4):561–79.PubMedCrossRef
3.
Marien P, Engelborghs S, Fabbro F, De Deyn PP. The lateralized linguistic cerebellum: a review and a new hypothesis. Brain Lang. 2001;79(3):580–600.PubMedCrossRef
4.
Kalashnikova LA, Zueva YV, Pugacheva OV, Korsakova NK. Cognitive impairments in cerebellar infarcts. Neurosci Behav Physiol. 2005;35(8):773–9.PubMedCrossRef
5.
6.
Molinari M, Leggio MG, Silveri MC. Verbal fluency and agrammatism. Int Rev Neurobiol. 1997;41:325–39.PubMedCrossRef
7.
Mariën P, Ackermann H, Adamaszek M, Barwood CH, Beaton A, Desmond J, et al. Consensus paper: Language and the cerebellum: an ongoing enigma. Cerebellum. 2014;13(3):386–410.PubMedPubMedCentral
8.
Mariën P, Saerens J, Nanhoe R, Moens E, Nagels G, Pickut BA, . . . De Deyn PP. Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings. J Neurol Sci. 1996;144(1-2):34-43.PubMedCrossRef
9.
10.
King M, Hernandez-Castillo CR, Poldrack RA, Ivry RB, Diedrichsen J. Functional boundaries in the human cerebellum revealed by a multi-domain task battery. Nat Neurosci. 2019;22(8):1371–8.PubMedPubMedCentralCrossRef
11.
Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage. 2009;44(2):489–501.PubMedCrossRef
12.
Frank B, Schoch B, Hein-Kropp C, Hövel M, Gizewski ER, Karnath HO, Timmann D. Aphasia, neglect and extinction are no prominent clinical signs in children and adolescents with acute surgical cerebellar lesions. Exp Brain Res. 2008;184(4):511–9.PubMedCrossRef
13.
Richter S, Schoch B, Kaiser O, Groetschel H, Hein-Kropp C, Maschke M, et al. Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J Neurophysiol. 2005;94(6):4108–20.PubMedCrossRef
14.
Frank B, Maschke M, Groetschel H, Berner M, Schoch B, Hein-Kropp C, et al. Aphasia and neglect are uncommon in cerebellar disease: negative findings in a prospective study in acute cerebellar stroke. Cerebellum. 2010;9(4):556–66.PubMedCrossRef
15.
Hilari K, Cruice M, Sorin-Peters R, Worrall L. Quality of life in aphasia: state of the art. Folia Phoniatr Logop. 2015;67(3):114–8.PubMedCrossRef
16.
Van der Giessen R, Satoer D, P., Koudstaal. The CODECS study: cognitive deficits in cerebellar stroke. Brain and Cognition. 2023;173:106102.PubMedCrossRef
17.
De Renzi E, Faglioni P. Normative data and screening power of a shortened version of the Token Test. Cortex. 1978;14(1):41–9.PubMedCrossRef
18.
19.
Satoer D, De Witte E, Bulté B, Bastiaanse R, Smits M, Vincent A, et al. Dutch Diagnostic Instrument for Mild Aphasia (DIMA): standardisation and a first clinical application in two brain tumour patients. Clin Linguist Phon. 2022;36(11):929–53.PubMedCrossRef
20.
Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. Williams and Wilkins: Lippincott; 2001a.
21.
Lezak MD. Neuropsychological Assessment. Oxford University Press; 2004.
22.
Lezak M, Howieson D, Bigler D, Tranel D. Neuropsychological assessment. Oxford University Press; 2012.
23.
Baillieux H, De Smet HJ, Dobbeleir A, Paquier PF, De Deyn PP, Mariën P. Cognitive and affective disturbances following focal cerebellar damage in adults: a neuropsychological and SPECT study. Cortex. 2010;46(7):869–79.PubMedCrossRef
24.
Fabbro F, Moretti R, Bava A. Language impairments in patients with cerebellar lesions. J Neurolinguistics. 2000;13:173–88.CrossRef
25.
Ackermann H, Mathiak K, Riecker A. The contribution of the cerebellum to speech production and speech perception: clinical and functional imaging data. Cerebellum. 2007;6(3):202–13.PubMedCrossRef
26.
Gasparini M, Di Piero V, Ciccarelli O, Cacioppo MM, Pantano P, Lenzi GL. Linguistic impairment after right cerebellar stroke: a case report. Eur J Neurol. 1999;6(3):353–6.PubMedCrossRef
27.
28.
Mariën P, Beaton A. The enigmatic linguistic cerebellum: clinical relevance and unanswered questions on nonmotor speech and language deficits in cerebellar disorders. Cerebellum Ataxias. 2014;1:12.PubMedPubMedCentralCrossRef
29.
30.
Chiricozzi FR, Clausi S, Molinari M, Leggio MG. Phonological short-term store impairment after cerebellar lesion: a single case study. Neuropsychologia. 2008;46(7):1940–53.PubMedCrossRef
31.
Kirschen MP, Davis-Ratner MS, Milner MW, Chen SH, Schraedley-Desmond P, Fisher PG, Desmond JE. Verbal memory impairments in children after cerebellar tumor resection. Behav Neurol. 2008;20(1-2):39–53.PubMedCrossRef
32.
Chen SH, Desmond JE. Cerebrocerebellar networks during articulatory rehearsal and verbal working memory tasks. Neuroimage. 2005;24(2):332–8.PubMedCrossRef
33.
34.
Justus T, Ravizza SM, Fiez JA, Ivry RB. Reduced phonological similarity effects in patients with damage to the cerebellum. Brain Lang. 2005;95(2):304–18.PubMedPubMedCentralCrossRef
35.
Leggio MG, Silveri MC, Petrosini L, Molinari M. Phonological grouping is specifically affected in cerebellar patients: a verbal fluency study. J Neurol Neurosurg Psychiatry. 2000;69(1):102–6.PubMedPubMedCentralCrossRef
36.
Whelan B-M, Murdoch BE. Unravelling subcortical linguistic substrates: comparison of thalamic versus cerebellar cognitive-linguistic regulation mechanisms. Aphasiology. 2005;19:1097–106.CrossRef
37.
D'Mello AM, Turkeltaub PE, Stoodley CJ. Cerebellar tDCS modulates neural circuits during semantic prediction: a combined tDCS-fMRI study. J Neurosci. 2017;37(6):1604–13.PubMedPubMedCentralCrossRef
38.
Xiang H, Lin C, Ma X, Zhang Z, Bower JM, Weng X, Gao JH. Involvement of the cerebellum in semantic discrimination: an fMRI study. Hum Brain Mapp. 2003;18(3):208–14.PubMedPubMedCentralCrossRef
39.
De Witte E, Satoer D, Robert E, Colle H, Verheyen S, Visch-Brink E, Mariën P. The Dutch Linguistic Intraoperative Protocol: a valid linguistic approach to awake brain surgery. Brain Lang. 2015;140:35–48.PubMedCrossRef
40.
Silveri MC. Contribution of the cerebellum and the basal ganglia to language production: speech, word fluency, and sentence construction-evidence from pathology. Cerebellum. 2021;20(2):282–94.PubMedCrossRef
41.
Silveri MC, Leggio MG, Molinari M. The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion. Neurology. 1994;44(11):2047–50.PubMedCrossRef
42.
Zettin M, Cappa SF, D'amico A, Rago R, Perino C, Perani D, Fazio F. Agrammatic speech production after a right cerebellar haemorrhage. Neurocase. 1997;3:373–80.CrossRef
43.
Miceli, G. (2019). Disturbi sintattici e dell’elaborazione di frasi nell’afasia. In P. L. Denes G., Guariglia C., Cappa S., Grossi D., & L. C. (Eds.), Manuale di neuropsicologia, normalità e patologia dei processi cognitivi. (pp. 68–281). Psicologia, Zanichelli.
44.
Dragoy O, Zyryanov A, Bronov O, Gordeyeva E, Gronskaya N, Kryuchkova O, et al. Functional linguistic specificity of the left frontal aslant tract for spontaneous speech fluency: evidence from intraoperative language mapping. Brain Lang. 2020;208:104836.PubMedCrossRef
45.
Zhang X, Chen Z, Li N, Liang J, Zou Y, Wu H, et al. Regional alteration within the cerebellum and the reorganization of the cerebrocerebellar system following poststroke aphasia. Neural Plast. 2022;2022:3481423.PubMedPubMedCentralCrossRef
46.
Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex. 2010;46(7):831–44.PubMedPubMedCentralCrossRef
47.
Kusano Y, Tanaka Y, Takasuna H, Wada N, Tada T, Kakizawa Y, Hongo K. Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report. J Neurosurg. 2006;104(2):329–31.PubMed
48.
49.
50.
Metadata
Title
Cerebellar-Induced Aphasia After Stroke: Evidence for the “Linguistic Cerebellum”
Authors
Djaina Satoer
Peter J. Koudstaal
Evy Visch-Brink
Ruben S. van der Giessen
Publication date
20-01-2024
Publisher
Springer US
Keywords
Aphasia
Stroke
Published in
The Cerebellum
Print ISSN: 1473-4222
Electronic ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-024-01658-1