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BMC Neurology
Published in: BMC Neurology 1/2023

Open Access 01-12-2023 | Apallic Syndrome | Research

EEG complexity correlates with residual consciousness level of disorders of consciousness

Authors: Yangfeng Liu, Wentao Zeng, Na Pan, Xiaoyu Xia, Yonghua Huang, Jianghong He

Published in: BMC Neurology | Issue 1/2023

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Abstract

Background and objective

Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders of consciousness (DOC) to improve consciousness detection. We tested the relationships between neural complexity measured on EEG and residual consciousness levels in DOC patients.

Methods

Resting-state EEG was recorded from twenty-five patients with DOC. Lempel–Ziv complexity (LZC) and permutation Lempel–Ziv complexity (PLZC) were measured on the EEG, and their relationships were analyzed with the consciousness levels of the patients.

Results

PLZC and LZC values significantly distinguished patients with a minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/UWS), and healthy controls. PLZC was significantly correlated with the Coma Recovery Scale-Revised (CRS-R) scores of DOC patients in the global brain, particularly in electrodes locating in the anterior and posterior brain regions. Patients with higher CRS-R scores showed higher PLZC values. The significant difference in PLZC values between MCS and VS/UWS was mainly located in the bilateral frontal and right hemisphere regions.

Conclusion

Neural complexity measured on EEG correlates with residual consciousness levels of DOC patients. PLZC showed higher sensitivity than LZC in the classification of consciousness levels.
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Metadata
Title
EEG complexity correlates with residual consciousness level of disorders of consciousness
Authors
Yangfeng Liu
Wentao Zeng
Na Pan
Xiaoyu Xia
Yonghua Huang
Jianghong He
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-023-03167-w

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