Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Neurology
Published in: BMC Neurology 1/2023

Open Access 01-12-2023 | Magnetic Resonance Imaging | Case Report

Anterior horn damage in brachial multisegmental amyotrophy with superficial siderosis and dural tear: an autopsy case report

Authors: Yusuke Takahashi, Minori Kodaira, Mitsunori Yamada, Kai Uehara, Kiyoshi Ito, Tomoki Kaneko, Hiroki Ohashi, Masahide Yazaki, Yoshiki Sekijima

Published in: BMC Neurology | Issue 1/2023

Login to get access

Abstract

Background

Patients with superficial siderosis (SS) rarely show brachial multisegmental amyotrophy with ventral intraspinal fluid collection accompanied with dural tear.

Case presentation

We describe spinal cord pathology of a 58-year-old man who developed brachial multisegmental amyotrophy with ventral intraspinal fluid collection from the cervical to lumbar spinal levels accompanied with SS, dural tear, and snake-eyes appearance on magnetic resonance imaging (MRI). Radiological and pathological analyses detected diffuse and prominent superficial deposition of hemosiderin in the central nervous system. Snake-eyes appearance on MRI expanded from the C3 to C7 spinal levels without apparent cervical canal stenosis. Pathologically, severe neuronal loss at both anterior horns and intermediate zone was expanded from the upper cervical (C3) to middle thoracic (Th5) spinal gray matter, and these findings were similar to compressive myelopathy.

Conclusion

Extensive damage of the anterior horns in our patient may be due to dynamic compression induced by ventral intraspinal fluid collection.
Literature
1.
Fearnley JM, Stevens JM, Rudge P. Superficial siderosis of the central nervous system. Brain. 1995;118:1051–66.CrossRefPubMed
2.
3.
Kumar N, Cohen-Gadol AA, Wright RA, Miller GM, Piepgras DG, Ahlskog JE. Superficial siderosis. Neurology. 2006;66:1144–52.CrossRefPubMed
4.
Deluca GC, Boes CJ, Krueger BR, Mokri B, Kumar N. Ventral intraspinal fluid-filled collection secondary to CSF leak presenting as bibrachial amyotrophy. Neurology. 2011;76:1439–40.CrossRefPubMed
5.
Morishima R, Takai K, Ando T, Nakata Y, Shimizu T, Taniguchi M. Brachial multisegmental amyotrophy caused by cervical anterior horn cell disorder associated with a spinal CSF leak: a report of five cases. J Neurol. 2019;266:2679–84.CrossRefPubMed
6.
Iwase R, Kanouchi T, Yoshii T, Ishiguro T, Hirai T, Okawa A, Yokota T, Sanjo N. Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. J Neurol Sci. 2022;436: 120248.CrossRefPubMed
7.
Kameyama T, Ando T, Yanagi T, Yasui K, Sobue G. Cervical spondylotic amyotrophy. Magnetic resonance imaging demonstration of intrinsic cord pathology. Spine (Phila Pa 1976). 1998;23:448–52.CrossRefPubMed
8.
Mizuno J, Nakagawa H, Chang HS, Hashizume Y. Postmortem study of the spinal cord showing snake-eyes appearance due to damage by ossification of the posterior longitudinal ligament and kyphotic deformity. Spinal Cord. 2005;43:503–7.CrossRefPubMed
9.
Ito T, Oyanagi K, Takahashi H, Takahashi HE, Ikuta F. Cervical spondylotic myelopathy. Clinicopathologic study on the progression pattern and thin myelinated fibers of the lesions of seven patients examined during complete autopsy. Spine (Phila Pa 1976). 2005;21:827–33.CrossRef
10.
Hirayama K. Juvenile muscular atrophy of distal upper extremity (Hirayama disease). Intern Med. 2000;39:283–90.CrossRefPubMed
Metadata
Title
Anterior horn damage in brachial multisegmental amyotrophy with superficial siderosis and dural tear: an autopsy case report
Authors
Yusuke Takahashi
Minori Kodaira
Mitsunori Yamada
Kai Uehara
Kiyoshi Ito
Tomoki Kaneko
Hiroki Ohashi
Masahide Yazaki
Yoshiki Sekijima
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-023-03180-z

Other articles of this Issue 1/2023

BMC Neurology 1/2023 Go to the issue

Research

Long-term effects of natalizumab on MRI activity and clinical outcomes in Japanese patients with relapsing-remitting multiple sclerosis

Research

Efficacy and safety of eptinezumab in patients with chronic migraine and medication-overuse headache: a randomized, double-blind, placebo-controlled study

Case Report

A novel C19ORF12 mutation in two MPAN sisters treated with deferiprone

Research

Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?

Research

Bleeding risk and mortality according to antithrombotic agents’ exposure in cancer-related stroke patients: nationwide population-based cohort study in South Korea

Research

Cerebrolysin as an Early Add-on to Reperfusion Therapy: Risk of Hemorrhagic Transformation after Ischemic Stroke (CEREHETIS), a prospective, randomized, multicenter pilot study