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Published in: Current Psychiatry Reports 8/2019

01-08-2019 | Antipsychotics | Geriatric Disorders (JA Cheong, Section Editor)

Management of Behavioral and Psychological Symptoms of Dementia

Authors: Laurel J. Bessey, Art Walaszek

Published in: Current Psychiatry Reports | Issue 8/2019

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Abstract

Purpose of Review

We review non-pharmacological and pharmacological approaches to managing behavioral and psychological symptoms of dementia (BPSD). We examine methods for assessment and evidence for interventions, focusing on recent findings and innovations. Finally, we recommend an algorithm for management of BPSD.

Recent Findings

Training of formal caregivers is the most effective intervention for BPSD; other non-pharmacological interventions are also beneficial. Antidepressants and antipsychotics remain a mainstay of pharmacological treatment for BPSD. There is limited evidence supporting the use of stimulants, cognitive enhancers, dextromethorphan/quinidine, benzodiazepines, anticonvulsants, and pimavanserin.

Summary

The management of BPSD is highly individualized. Following thorough assessment, the initial step is addressing contributing medical problems. Non-pharmacological interventions should be tried prior to pharmacological interventions. Antipsychotics should be prescribed only when behaviors pose a significant safety risk or if the person with dementia is very distressed. New approaches will be needed to address an increasing population of people with dementia.
Literature
1.
go back to reference Prince M, Guerchet M, Prina M. Policy brief for heads of government: the global impact of dementia 2013–2050. Alzheimer’s disease international; 2013. Prince M, Guerchet M, Prina M. Policy brief for heads of government: the global impact of dementia 2013–2050. Alzheimer’s disease international; 2013.
2.
go back to reference Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatr Clin Neurosci. 2000;12(2):233–9.CrossRef Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatr Clin Neurosci. 2000;12(2):233–9.CrossRef
3.
go back to reference Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, et al. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement. 2011;7. United States: Copyright (c) 2011 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved:532–9.CrossRef Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, et al. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement. 2011;7. United States: Copyright (c) 2011 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved:532–9.CrossRef
4.
go back to reference Kales HC, Gitlin LN, Lyketsos CG. Assessment and management of behavioral and psychological symptoms of dementia. BMJ. 2015;350:h369.CrossRef Kales HC, Gitlin LN, Lyketsos CG. Assessment and management of behavioral and psychological symptoms of dementia. BMJ. 2015;350:h369.CrossRef
5.
go back to reference Beeri MS, Werner P, Davidson M, Noy S. The cost of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Alzheimer's disease patients. Int J Geriatr Psychiatry. 2002;17(5):403–8.CrossRef Beeri MS, Werner P, Davidson M, Noy S. The cost of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Alzheimer's disease patients. Int J Geriatr Psychiatry. 2002;17(5):403–8.CrossRef
6.
go back to reference Kales HC, Gitlin LN, Lyketsos CG. Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel. J Am Geriatr Soc. 2014;62(4):762–9.CrossRef Kales HC, Gitlin LN, Lyketsos CG. Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel. J Am Geriatr Soc. 2014;62(4):762–9.CrossRef
7.
go back to reference Cheng ST. Dementia caregiver burden: a research update and critical analysis. Curr Psychiatry Rep. 2017;19(9):64.CrossRef Cheng ST. Dementia caregiver burden: a research update and critical analysis. Curr Psychiatry Rep. 2017;19(9):64.CrossRef
8.
go back to reference Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–8.CrossRef Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–8.CrossRef
9.
go back to reference • Kales HC, Gitlin LN, Stanislawski B, Myra Kim H, Marx K, Turnwald M, et al. Effect of the WeCareAdvisor on family caregiver outcomes in dementia: a pilot randomized controlled trial. BMC Geriatr. 2018;18(1):113 This pilot RCT examines a web-based toold developed to enable family caregivers to assess, manage, and track BPSD. CrossRef • Kales HC, Gitlin LN, Stanislawski B, Myra Kim H, Marx K, Turnwald M, et al. Effect of the WeCareAdvisor on family caregiver outcomes in dementia: a pilot randomized controlled trial. BMC Geriatr. 2018;18(1):113 This pilot RCT examines a web-based toold developed to enable family caregivers to assess, manage, and track BPSD. CrossRef
10.
go back to reference • Surr CA, Griffiths AW, Kelley R. Implementing dementia care mapping as a practice development tool in dementia care services: a systematic review. Clin Interv Aging. 2018;13:165–77 This systematic review discusses dementia care mapping including barriers, and information about implementation. CrossRef • Surr CA, Griffiths AW, Kelley R. Implementing dementia care mapping as a practice development tool in dementia care services: a systematic review. Clin Interv Aging. 2018;13:165–77 This systematic review discusses dementia care mapping including barriers, and information about implementation. CrossRef
11.
go back to reference Howell T. The Wisconsin Star method: understanding and addressing complexity in geriatrics. In: Malone M, Capezuti E, Palmer R, editors. Geriatrics models of care: bringing ‘best practice’ to an aging. America: Springer International Publishing; 2015. p. 87–94.CrossRef Howell T. The Wisconsin Star method: understanding and addressing complexity in geriatrics. In: Malone M, Capezuti E, Palmer R, editors. Geriatrics models of care: bringing ‘best practice’ to an aging. America: Springer International Publishing; 2015. p. 87–94.CrossRef
12.
go back to reference Lichtwarck B, Tvera A-M, Roen I. Targeted Interdisciplinary Model for Evaluation and Treatment of neuropsychiatric symptoms – Manual, 2e. Ottestad, Norway: Centre for Old Age Psychiatric Research, Innlandet Hospital Trust; 2017. Lichtwarck B, Tvera A-M, Roen I. Targeted Interdisciplinary Model for Evaluation and Treatment of neuropsychiatric symptoms – Manual, 2e. Ottestad, Norway: Centre for Old Age Psychiatric Research, Innlandet Hospital Trust; 2017.
13.
go back to reference • Lichtwarck B, Selbaek G, Kirkevold O, Rokstad AMM, Benth JS, Lindstrom JC, et al. Targeted interdisciplinary model for evaluation and treatment of neuropsychiatric symptoms: a cluster randomized controlled trial. Am J Geriatr Psychiatry. 2018;26(1):25–38 This is a recent RCT on a manualized approach (TIME) used in the treatment of moderate to severe agitation in people with dementia.CrossRef • Lichtwarck B, Selbaek G, Kirkevold O, Rokstad AMM, Benth JS, Lindstrom JC, et al. Targeted interdisciplinary model for evaluation and treatment of neuropsychiatric symptoms: a cluster randomized controlled trial. Am J Geriatr Psychiatry. 2018;26(1):25–38 This is a recent RCT on a manualized approach (TIME) used in the treatment of moderate to severe agitation in people with dementia.CrossRef
14.
go back to reference Holtta E, Laakkonen ML, Laurila JV, Strandberg TE, Tilvis R, Kautiainen H, et al. The overlap of delirium with neuropsychiatric symptoms among patients with dementia. Am J Geriatr Psychiatry. 2011;19(12):1034–41.CrossRef Holtta E, Laakkonen ML, Laurila JV, Strandberg TE, Tilvis R, Kautiainen H, et al. The overlap of delirium with neuropsychiatric symptoms among patients with dementia. Am J Geriatr Psychiatry. 2011;19(12):1034–41.CrossRef
16.
go back to reference Jump RLP, Crnich CJ, Mody L, Bradley SF, Nicolle LE, Yoshikawa TT. Infectious diseases in older adults of long-term care facilities: update on approach to diagnosis and management. J Am Geriatr Soc. 2018;66(4):789–803.CrossRef Jump RLP, Crnich CJ, Mody L, Bradley SF, Nicolle LE, Yoshikawa TT. Infectious diseases in older adults of long-term care facilities: update on approach to diagnosis and management. J Am Geriatr Soc. 2018;66(4):789–803.CrossRef
17.
go back to reference D'Agata E, Loeb MB, Mitchell SL. Challenges in assessing nursing home residents with advanced dementia for suspected urinary tract infections. J Am Geriatr Soc. 2013;61(1):62–6.CrossRef D'Agata E, Loeb MB, Mitchell SL. Challenges in assessing nursing home residents with advanced dementia for suspected urinary tract infections. J Am Geriatr Soc. 2013;61(1):62–6.CrossRef
18.
go back to reference • van Buul LW, Vreeken HL, Bradley SF, Crnich CJ, Drinka PJ, Geerlings SE, et al. The development of a decision tool for the empiric treatment of suspected urinary tract infection in frail older adults: a Delphi consensus procedure. J Am Med Dir Assoc. 2018;19(9):757–64 This is a decision tool based on a consensus consensus regarding treatment of suspected UTI in older adults. CrossRef • van Buul LW, Vreeken HL, Bradley SF, Crnich CJ, Drinka PJ, Geerlings SE, et al. The development of a decision tool for the empiric treatment of suspected urinary tract infection in frail older adults: a Delphi consensus procedure. J Am Med Dir Assoc. 2018;19(9):757–64 This is a decision tool based on a consensus consensus regarding treatment of suspected UTI in older adults. CrossRef
19.
go back to reference Hendriks SA, Smalbrugge M, Galindo-Garre F, Hertogh CM, van der Steen JT. From admission to death: prevalence and course of pain, agitation, and shortness of breath, and treatment of these symptoms in nursing home residents with dementia. J Am Med Dir Assoc. 2015;16(6):475–81.CrossRef Hendriks SA, Smalbrugge M, Galindo-Garre F, Hertogh CM, van der Steen JT. From admission to death: prevalence and course of pain, agitation, and shortness of breath, and treatment of these symptoms in nursing home residents with dementia. J Am Med Dir Assoc. 2015;16(6):475–81.CrossRef
20.
go back to reference •• Husebo BS, Achterberg W, Flo E. Identifying and managing pain in people with Alzheimer's disease and other types of dementia: a systematic review. CNS Drugs. 2016;30(6):481–97 A systematic review on managing pain in people with dementia. CrossRef •• Husebo BS, Achterberg W, Flo E. Identifying and managing pain in people with Alzheimer's disease and other types of dementia: a systematic review. CNS Drugs. 2016;30(6):481–97 A systematic review on managing pain in people with dementia. CrossRef
21.
go back to reference • Bullock L, Bedson J, Jordan JL, Bartlam B, Chew-Graham CA, Campbell P. Pain assessment and pain treatment for community-dwelling people with dementia: a systematic review and narrative synthesis. Int J Geriatr psychiatry. 2019; Very recent review on pain assessment and treatment in community dwelling people with dementia. • Bullock L, Bedson J, Jordan JL, Bartlam B, Chew-Graham CA, Campbell P. Pain assessment and pain treatment for community-dwelling people with dementia: a systematic review and narrative synthesis. Int J Geriatr psychiatry. 2019; Very recent review on pain assessment and treatment in community dwelling people with dementia.
22.
go back to reference • Jaidi Y, Nonnonhou V, Kanagaratnam L, Bertholon LA, Badr S, Noel V, et al. Reduction of the anticholinergic burden makes it possible to decrease behavioral and psychological symptoms of dementia. Am J Geriatr Psychiatry. 2018;26(3):280–8 This study shows that reducing anticholinergic burden makes it possible to reduce BPSD and caregiver burden. CrossRef • Jaidi Y, Nonnonhou V, Kanagaratnam L, Bertholon LA, Badr S, Noel V, et al. Reduction of the anticholinergic burden makes it possible to decrease behavioral and psychological symptoms of dementia. Am J Geriatr Psychiatry. 2018;26(3):280–8 This study shows that reducing anticholinergic burden makes it possible to reduce BPSD and caregiver burden. CrossRef
23.
go back to reference •• American Geriatrics Society beers criteria® update expert panel American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially. Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019. https://doi.org/10.1111/jgs.15767. Recent update of Beers Criteria for potentially inappropriate medication use in older adults. •• American Geriatrics Society beers criteria® update expert panel American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially. Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019. https://​doi.​org/​10.​1111/​jgs.​15767.​ Recent update of Beers Criteria for potentially inappropriate medication use in older adults.
24.
go back to reference Rongen S, Kramers C, O'Mahony D, Feuth TB, Olde Rikkert MG, Ahmed AI. Potentially inappropriate prescribing in older patients admitted to psychiatric hospital. Int J Geriatr Psychiatry. 2016;31(2):137–45.CrossRef Rongen S, Kramers C, O'Mahony D, Feuth TB, Olde Rikkert MG, Ahmed AI. Potentially inappropriate prescribing in older patients admitted to psychiatric hospital. Int J Geriatr Psychiatry. 2016;31(2):137–45.CrossRef
25.
go back to reference Livingston G, Kelly L, Lewis-Holmes E, Baio G, Morris S, Patel N, et al. A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol Assess. 2014;18(39):1–226.CrossRef Livingston G, Kelly L, Lewis-Holmes E, Baio G, Morris S, Patel N, et al. A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol Assess. 2014;18(39):1–226.CrossRef
26.
go back to reference •• Brasure M, Jutkowitz E, Fuchs E, Nelson VA, Kane RA, Shippee T, et al. AHRQ comparative effectiveness reviews. Nonpharmacologic interventions for agitation and aggression in dementia. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016. This review compares the effectiveness of nonpharmacological interventions for agitation and aggression in dementia. •• Brasure M, Jutkowitz E, Fuchs E, Nelson VA, Kane RA, Shippee T, et al. AHRQ comparative effectiveness reviews. Nonpharmacologic interventions for agitation and aggression in dementia. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016. This review compares the effectiveness of nonpharmacological interventions for agitation and aggression in dementia.
27.
go back to reference Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Faes K, Annemans L. Effectiveness of supporting informal caregivers of people with dementia: a systematic review of randomized and non-randomized controlled trials. J Alzheimers Dis. 2016;52(3):929–65.CrossRef Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Faes K, Annemans L. Effectiveness of supporting informal caregivers of people with dementia: a systematic review of randomized and non-randomized controlled trials. J Alzheimers Dis. 2016;52(3):929–65.CrossRef
28.
go back to reference Gilhooly KJ, Gilhooly ML, Sullivan MP, McIntyre A, Wilson L, Harding E, et al. A meta-review of stress, coping and interventions in dementia and dementia caregiving. BMC Geriatr. 2016;16:106.CrossRef Gilhooly KJ, Gilhooly ML, Sullivan MP, McIntyre A, Wilson L, Harding E, et al. A meta-review of stress, coping and interventions in dementia and dementia caregiving. BMC Geriatr. 2016;16:106.CrossRef
29.
go back to reference Williams K, Blyler D, Vidoni ED, Shaw C, Wurth J, Seabold D, et al. A randomized trial using telehealth technology to link caregivers with dementia care experts for in-home caregiving support: FamTechCare protocol. Res Nurs Health. 2018;41(3):219–27.CrossRef Williams K, Blyler D, Vidoni ED, Shaw C, Wurth J, Seabold D, et al. A randomized trial using telehealth technology to link caregivers with dementia care experts for in-home caregiving support: FamTechCare protocol. Res Nurs Health. 2018;41(3):219–27.CrossRef
30.
go back to reference Gitlin LN, Marx KA, Alonzi D, Kvedar T, Moody J, Trahan M, et al. Feasibility of the tailored activity program for hospitalized (TAP-H) patients with behavioral symptoms. Gerontologist. 2016:gnw052. Gitlin LN, Marx KA, Alonzi D, Kvedar T, Moody J, Trahan M, et al. Feasibility of the tailored activity program for hospitalized (TAP-H) patients with behavioral symptoms. Gerontologist. 2016:gnw052.
31.
go back to reference Gitlin LN, Arthur P, Piersol C, Hessels V, Wu SS, Dai Y, et al. Targeting behavioral symptoms and functional decline in dementia: a randomized clinical trial. J Am Geriatr Soc. 2018;66(2):339–45.CrossRef Gitlin LN, Arthur P, Piersol C, Hessels V, Wu SS, Dai Y, et al. Targeting behavioral symptoms and functional decline in dementia: a randomized clinical trial. J Am Geriatr Soc. 2018;66(2):339–45.CrossRef
32.
go back to reference Trahan MA, Kuo J, Carlson MC, Gitlin LN. A systematic review of strategies to foster activity engagement in persons with dementia. Health Educ Behav. 2014;41(1 Suppl):70s–83s.CrossRef Trahan MA, Kuo J, Carlson MC, Gitlin LN. A systematic review of strategies to foster activity engagement in persons with dementia. Health Educ Behav. 2014;41(1 Suppl):70s–83s.CrossRef
33.
go back to reference •• Scales K, Zimmerman S, Miller SJ. Evidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of DementiaEvidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of Dementia. Gerontologist. 2018;58(suppl_1):S88–s102. This article provides evidence-based recommendations for nonpharmacological practices for dementia care that are helpful to persons implementing these practices. CrossRef •• Scales K, Zimmerman S, Miller SJ. Evidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of DementiaEvidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of Dementia. Gerontologist. 2018;58(suppl_1):S88–s102. This article provides evidence-based recommendations for nonpharmacological practices for dementia care that are helpful to persons implementing these practices. CrossRef
34.
go back to reference • Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2015;(4):Cd006489 This is the most updated review of the effects of exercise programs in persons with dementia. • Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2015;(4):Cd006489 This is the most updated review of the effects of exercise programs in persons with dementia.
35.
go back to reference Barreto Pde S, Demougeot L, Pillard F, Lapeyre-Mestre M, Rolland Y. Exercise training for managing behavioral and psychological symptoms in people with dementia: a systematic review and meta-analysis. Ageing Res Rev. 2015;24(Pt B):274–85.CrossRef Barreto Pde S, Demougeot L, Pillard F, Lapeyre-Mestre M, Rolland Y. Exercise training for managing behavioral and psychological symptoms in people with dementia: a systematic review and meta-analysis. Ageing Res Rev. 2015;24(Pt B):274–85.CrossRef
36.
go back to reference •• Kales HC, Lyketsos CG, Miller EM, Ballard C. Management of behavioral and psychological symptoms in people with Alzheimer's disease: an international Delphi consensus. Int Psychogeriatr. 2019;31(1):83–90 This is the most recent published consensus report on management of BPSD. CrossRef •• Kales HC, Lyketsos CG, Miller EM, Ballard C. Management of behavioral and psychological symptoms in people with Alzheimer's disease: an international Delphi consensus. Int Psychogeriatr. 2019;31(1):83–90 This is the most recent published consensus report on management of BPSD. CrossRef
37.
go back to reference Legere LE, McNeill S, Schindel Martin L, Acorn M, An D. Nonpharmacological approaches for behavioural and psychological symptoms of dementia in older adults: a systematic review of reviews. J Clin Nurs. 2018;27(7–8):e1360–e76.CrossRef Legere LE, McNeill S, Schindel Martin L, Acorn M, An D. Nonpharmacological approaches for behavioural and psychological symptoms of dementia in older adults: a systematic review of reviews. J Clin Nurs. 2018;27(7–8):e1360–e76.CrossRef
38.
go back to reference • Orgeta V, Qazi A, Spector A, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. Br J Psychiatry. 2015;207(4):293–8 A review of six trials of psychological treatments found evidence of efficacy for depression and anxiety in milder forms of cognitive impairment. CrossRef • Orgeta V, Qazi A, Spector A, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. Br J Psychiatry. 2015;207(4):293–8 A review of six trials of psychological treatments found evidence of efficacy for depression and anxiety in milder forms of cognitive impairment. CrossRef
39.
go back to reference Kiosses DN, Alexopoulos GS. Problem-solving therapy in the elderly. Curr Treat Options Psychiatry. 2014;1(1):15–26.CrossRef Kiosses DN, Alexopoulos GS. Problem-solving therapy in the elderly. Curr Treat Options Psychiatry. 2014;1(1):15–26.CrossRef
40.
go back to reference Abraha I, Rimland JM, Lozano-Montoya I, Dell'Aquila G, Velez-Diaz-Pallares M, Trotta FM, et al. Simulated presence therapy for dementia. Cochrane Database Syst Rev. 2017;(4):Cd011882. Abraha I, Rimland JM, Lozano-Montoya I, Dell'Aquila G, Velez-Diaz-Pallares M, Trotta FM, et al. Simulated presence therapy for dementia. Cochrane Database Syst Rev. 2017;(4):Cd011882.
41.
go back to reference • Wang J, Yu JT, Wang HF, Meng XF, Wang C, Tan CC, et al. Pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2015;86(1):101–9 This is one of a number of recent reviews of medications options for the treatment of BPSD. CrossRef • Wang J, Yu JT, Wang HF, Meng XF, Wang C, Tan CC, et al. Pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2015;86(1):101–9 This is one of a number of recent reviews of medications options for the treatment of BPSD. CrossRef
42.
go back to reference Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer's disease. Expert Opin Pharmacother. 2017;18(6):611–20.CrossRef Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer's disease. Expert Opin Pharmacother. 2017;18(6):611–20.CrossRef
43.
go back to reference Davies SJ, Burhan AM, Kim D, Gerretsen P, Graff-Guerrero A, Woo VL, et al. Sequential drug treatment algorithm for agitation and aggression in Alzheimer's and mixed dementia. J Psychopharmacol. 2018;32(5):509–23.CrossRef Davies SJ, Burhan AM, Kim D, Gerretsen P, Graff-Guerrero A, Woo VL, et al. Sequential drug treatment algorithm for agitation and aggression in Alzheimer's and mixed dementia. J Psychopharmacol. 2018;32(5):509–23.CrossRef
44.
go back to reference • Farina N, Morrell L, Banerjee S. What is the therapeutic value of antidepressants in dementia? A narrative review. Int J Geriatr Psychiatry. 2017;32(1):32–49 The authors review the literature on the role of antidepressant for addressing BPSD. CrossRef • Farina N, Morrell L, Banerjee S. What is the therapeutic value of antidepressants in dementia? A narrative review. Int J Geriatr Psychiatry. 2017;32(1):32–49 The authors review the literature on the role of antidepressant for addressing BPSD. CrossRef
45.
go back to reference •• Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, et al. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trialEffect of Citalopram on Agitation in Alzheimer Disease. Jama. 2014;311(7):682–91. This seminal study demonstrated the efficacy of citalopram for agitation in patients with Alzheimer’s disease, but also confirmed that citalopram can cause QT prolongation. CrossRef •• Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, et al. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trialEffect of Citalopram on Agitation in Alzheimer Disease. Jama. 2014;311(7):682–91. This seminal study demonstrated the efficacy of citalopram for agitation in patients with Alzheimer’s disease, but also confirmed that citalopram can cause QT prolongation. CrossRef
46.
go back to reference Peters ME, Vaidya V, Drye LT, Devanand DP, Mintzer JE, Pollock BG, et al. Citalopram for the treatment of agitation in Alzheimer dementia: genetic influences. J Geriatr Psychiatry Neurol. 2016;29(2):59–64.CrossRef Peters ME, Vaidya V, Drye LT, Devanand DP, Mintzer JE, Pollock BG, et al. Citalopram for the treatment of agitation in Alzheimer dementia: genetic influences. J Geriatr Psychiatry Neurol. 2016;29(2):59–64.CrossRef
48.
go back to reference McCleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2016;(11):Cd009178. McCleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2016;(11):Cd009178.
49.
go back to reference Nardell M, Tampi RR. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Dement. 2014;29(2):123–32.CrossRef Nardell M, Tampi RR. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Dement. 2014;29(2):123–32.CrossRef
50.
go back to reference Scoralick FM, Louzada LL, Quintas JL, Naves JO, Camargos EF, Nobrega OT. Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study. Psychogeriatrics. 2017;17(2):89–96.CrossRef Scoralick FM, Louzada LL, Quintas JL, Naves JO, Camargos EF, Nobrega OT. Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study. Psychogeriatrics. 2017;17(2):89–96.CrossRef
51.
go back to reference De Picker L, Van Den Eede F, Dumont G, Moorkens G, Sabbe BG. Antidepressants and the risk of hyponatremia: a class-by-class review of literature. Psychosomatics. 2014;55(6):536–47.CrossRef De Picker L, Van Den Eede F, Dumont G, Moorkens G, Sabbe BG. Antidepressants and the risk of hyponatremia: a class-by-class review of literature. Psychosomatics. 2014;55(6):536–47.CrossRef
52.
go back to reference Viramontes TS, Truong H, Linnebur SA. Antidepressant-induced Hyponatremia in older adults. Consult Pharm. 2016;31(3):139–50.CrossRef Viramontes TS, Truong H, Linnebur SA. Antidepressant-induced Hyponatremia in older adults. Consult Pharm. 2016;31(3):139–50.CrossRef
53.
go back to reference Tampi RR, Tampi DJ, Balachandran S, Srinivasan S. Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses. Ther Adv Chronic Dis. 2016;7(5):229–45.CrossRef Tampi RR, Tampi DJ, Balachandran S, Srinivasan S. Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses. Ther Adv Chronic Dis. 2016;7(5):229–45.CrossRef
54.
go back to reference • Maglione M, Maher AR, Hu J, Wang Z, Shanman R, Shekelle PG, et al. AHRQ comparative effectiveness reviews. Off-label use of atypical antipsychotics: An update. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011. Though a bit dated at this point, this AHRQ review’s conclusions that risperidone, olanzapine and aripiprazole are the antipsychotics most likely to improve agitation, psychosis and overall BPSD are still valid. • Maglione M, Maher AR, Hu J, Wang Z, Shanman R, Shekelle PG, et al. AHRQ comparative effectiveness reviews. Off-label use of atypical antipsychotics: An update. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011. Though a bit dated at this point, this AHRQ review’s conclusions that risperidone, olanzapine and aripiprazole are the antipsychotics most likely to improve agitation, psychosis and overall BPSD are still valid.
55.
go back to reference •• Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543–6 This APA Practice Guideline is a state-of-the art review of the use of antipsychotics for BPSD. CrossRef •• Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543–6 This APA Practice Guideline is a state-of-the art review of the use of antipsychotics for BPSD. CrossRef
56.
go back to reference • Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med. 2006;355(15):1525–38 The CATIE-AD study represents the most comprehensive attempt to date to determine the role of antipsychotics in the treatment of BPSD. CrossRef • Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med. 2006;355(15):1525–38 The CATIE-AD study represents the most comprehensive attempt to date to determine the role of antipsychotics in the treatment of BPSD. CrossRef
57.
go back to reference Van Leeuwen E, Petrovic M, van Driel ML, De Sutter AI, Vander Stichele R, Declercq T, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018;(3):Cd007726. Van Leeuwen E, Petrovic M, van Driel ML, De Sutter AI, Vander Stichele R, Declercq T, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018;(3):Cd007726.
58.
go back to reference Tampi RR, Tampi DJ. Efficacy and tolerability of benzodiazepines for the treatment of behavioral and psychological symptoms of dementia: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Dement. 2014;29(7):565–74.CrossRef Tampi RR, Tampi DJ. Efficacy and tolerability of benzodiazepines for the treatment of behavioral and psychological symptoms of dementia: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Dement. 2014;29(7):565–74.CrossRef
60.
go back to reference • Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, et al. Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. Am J Psychiatry. 2015;172(8):731–42 After Alzheimer’s disease, one of the most common causes of dementia is Lewy body disease, which is notable for its significant risk of BPSD. This review covers treatments for LBD. CrossRef • Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, et al. Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. Am J Psychiatry. 2015;172(8):731–42 After Alzheimer’s disease, one of the most common causes of dementia is Lewy body disease, which is notable for its significant risk of BPSD. This review covers treatments for LBD. CrossRef
61.
go back to reference Ballard C, Thomas A, Gerry S, Yu LM, Aarsland D, Merritt C, et al. A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD). J Am Med Dir Assoc. 2015;16(4):316–22.CrossRef Ballard C, Thomas A, Gerry S, Yu LM, Aarsland D, Merritt C, et al. A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD). J Am Med Dir Assoc. 2015;16(4):316–22.CrossRef
62.
go back to reference Bozymski KM, Lowe DK, Pasternak KM, Gatesman TL, Crouse EL. Pimavanserin: a novel antipsychotic for Parkinson's disease psychosis. Ann Pharmacother. 2017;51(6):479–87.CrossRef Bozymski KM, Lowe DK, Pasternak KM, Gatesman TL, Crouse EL. Pimavanserin: a novel antipsychotic for Parkinson's disease psychosis. Ann Pharmacother. 2017;51(6):479–87.CrossRef
63.
go back to reference Ballard C, Banister C, Khan Z, Cummings J, Demos G, Coate B, et al. Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018;17(3):213–22.CrossRef Ballard C, Banister C, Khan Z, Cummings J, Demos G, Coate B, et al. Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018;17(3):213–22.CrossRef
64.
go back to reference Ruthirakuhan MT, Herrmann N, Abraham EH, Chan S, Lanctot KL. Pharmacological interventions for apathy in Alzheimer's disease. Cochrane Database Syst Rev. 2018;(5):Cd012197. Ruthirakuhan MT, Herrmann N, Abraham EH, Chan S, Lanctot KL. Pharmacological interventions for apathy in Alzheimer's disease. Cochrane Database Syst Rev. 2018;(5):Cd012197.
65.
go back to reference • Padala PR, Padala KP, Lensing SY, Ramirez D, Monga V, Bopp MM, et al. Methylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer's Disease: A Double-Blind, Randomized, Placebo-Controlled TrialMethylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer’s Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Am J Psychiatry. 2018;175(2):159–68. The most rigorous study to date of the use of a stimulant for apathy due to dementia demonstrated efficacy but also raised concerns about tolerability, specifically increased blood pressure. • Padala PR, Padala KP, Lensing SY, Ramirez D, Monga V, Bopp MM, et al. Methylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer's Disease: A Double-Blind, Randomized, Placebo-Controlled TrialMethylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer’s Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Am J Psychiatry. 2018;175(2):159–68. The most rigorous study to date of the use of a stimulant for apathy due to dementia demonstrated efficacy but also raised concerns about tolerability, specifically increased blood pressure.
66.
go back to reference Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, et al. Effect of dextromethorphan-quinidine on agitation in patients with Alzheimer disease dementia: a randomized clinical trial. Jama. 2015;314(12):1242–54.CrossRef Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, et al. Effect of dextromethorphan-quinidine on agitation in patients with Alzheimer disease dementia: a randomized clinical trial. Jama. 2015;314(12):1242–54.CrossRef
67.
go back to reference Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, et al. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry. 2009;17:744–51.CrossRef Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, et al. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry. 2009;17:744–51.CrossRef
68.
go back to reference Kaster TS, Blumberger DM. Palliating severe refractory neuropsychiatric symptoms of dementia: is there a role for electroconvulsive therapy? Am J Geriatr Psychiatry. 2018;26(4):435–7.CrossRef Kaster TS, Blumberger DM. Palliating severe refractory neuropsychiatric symptoms of dementia: is there a role for electroconvulsive therapy? Am J Geriatr Psychiatry. 2018;26(4):435–7.CrossRef
69.
go back to reference van den Berg JF, Kruithof HC, Kok RM, Verwijk E, Spaans HP. Electroconvulsive therapy for agitation and aggression in dementia: a systematic review. Am J Geriatr Psychiatry. 2018;26(4):419–34.CrossRef van den Berg JF, Kruithof HC, Kok RM, Verwijk E, Spaans HP. Electroconvulsive therapy for agitation and aggression in dementia: a systematic review. Am J Geriatr Psychiatry. 2018;26(4):419–34.CrossRef
70.
go back to reference Walaszek A, Behavioral and psychological symptoms of dementia, American Psychiatric Association Publishing 2019 (in press). Walaszek A, Behavioral and psychological symptoms of dementia, American Psychiatric Association Publishing 2019 (in press).
Metadata
Title
Management of Behavioral and Psychological Symptoms of Dementia
Authors
Laurel J. Bessey
Art Walaszek
Publication date
01-08-2019
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 8/2019
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-019-1049-5

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