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01-10-2003 | Editorial

Antioxidant therapy in sepsis

Authors: Gerd Albuszies, Uwe Bernd Brückner

Published in: Intensive Care Medicine | Issue 10/2003

Excerpt

The assiduous quest for a "magic bullet" in the treatment of sepsis nowadays favors the investigation of oxidative stress and the role of anti-oxidative defense systems in order to develop new pharmacological approaches in this life-threatening disease. …

Rojkind M, Dominguez-Rosales JA, Nieto N, Greenwel P (2002) Role of hydrogen peroxide and oxidative stress in healing responses. Cell Mol Life Sci 59:1872–1891PubMed

Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-C1437PubMed

Takakura K, Xiaohong W, Takeuchi K, Yasuda Y, Fukuda S (2003) Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock. Anesthesiology 98:928–934PubMed

Benkusky NA, Lewis SJ, Kooy NW (1999) Peroxynitrite-mediated attenuation of alpha- and beta-adrenoceptor agonist-induced vascular responses in vivo. Eur J Pharmacol 364:151–158CrossRefPubMed

Suliman HB, Carraway MS, Piantadosi CA (2003) Postlipopolysaccharide oxidative damage of mitochondrial DNA. Am J Respir Crit Care Med 167:570–579CrossRefPubMed

Virag L, Szabó E, Gergely P, Szabó C (2003) Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 140–141:113–124

Forman HJ, Torres M (2002) Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med 166:S4-S8PubMed

Macdonald J, Galley HF, Webster NR (2003) Oxidative stress and gene expression in sepsis. Br J Anaesth 90:221–232CrossRefPubMed

Niki E, Noguchi N (2000) Evaluation of antioxidant capacity. What capacity is being measured by which method? IUBMB Life 50:323–329CrossRefPubMed

10.

Goode HF, Cowley HC, Walker BE, Howdle PD, Webster NR (1995) Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit Care Med 23:646–651PubMed

11.

Alonso de Vega JM, Diaz J, Serrano E, Carbonell LF (2002) Oxidative stress in critically ill patients with systemic inflammatory response syndrome. Crit Care Med 30:1782–1786PubMed

12.

Cowley HC, Bacon PJ, Goode HF, Webster NR, Jones JG, Menon DK (1996) Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors. Crit Care Med 24:1179–1183PubMed

13.

Pascual C, Karzai W, Meier-Hellmann A, Oberhoffer M, Horn A, Bredle D, Reinhart K (1998) Total plasma antioxidant capacity is not always decreased in sepsis. Crit Care Med 26:705–709PubMed

14.

Dasgupta A, Malhotra D, Levy H, Marcadis D, Blackwell W, Johnston D (1997) Decreased total antioxidant capacity but normal lipid hydroperoxide concentrations in sera of critically ill patients. Life Sci 60:335–340CrossRefPubMed

15.

Ritter C, Andrades M, Frota ML, Jr., Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med (http://dx.doi.org/10.1007/s00134-003-1789-9)

16.

Kharb S, Singh V, Ghalaut PS, Sharma A, Singh GP (2000) Role of oxygen free radicals in shock. J Assoc Physicians India 48:956–957PubMed

17.

Bela P, Bahl R, Sane AS, Sawant PH, Shah VR, Mishra VV, Trivedi HL (2001) Oxidative stress status: possible guideline for clinical management of critically ill patients. Panminerva Med 43:27–31PubMed

18.

Carbonell LF, Nadal JA, Llanos MC, Hernandez I, Nava E, Diaz J (2000) Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model. Crit Care Med 28:2002–2006PubMed

19.

Bakker J, Zhang H, Depierreux M, van Asbeck S, Vincent JL (1994) Effects of N-acetylcysteine in endotoxic shock. J Crit Care 9:236–243PubMed

20.

Spapen H, Zhang H, Demanet C, Vleminckx W, Vincent JL, Huyghens L (1998) Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 113:1616–1624PubMed

21.

Molnar Z, Shearer E, Lowe D (1999) N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 27:1100–1104PubMed

22.

Walsh TS, Lee A (1999) N-acetylcysteine administration in the critically ill. Intensive Care Med 25:432–434CrossRefPubMed

23.

Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, Radella F, Garcia I, Maier RV (2002) Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 236:814–822CrossRefPubMed

24.

Quinlan GJ, Margarson MP, Mumby S, Evans TW, Gutteridge JM (1998) Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion. Clin Sci (Lond) 95:459–465

25.

Cochrane Injuries Group Albumin Reviewers (1998) Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ 317:235–240PubMed

26.

Neuzil J, Thomas SR, Stocker R (1997) Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radic Biol Med 22:57–71CrossRefPubMed

27.

Carr A, Frei B (1999) Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 13:1007–1024PubMed

28.

Halliwell B, Clement MV, Ramalingam J, Long LH (2000) Hydrogen peroxide. Ubiquitous in cell culture and in vivo? IUBMB Life 50:251–257CrossRefPubMed

29.

Halliwell B (2003) Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett 540:3–6CrossRefPubMed

30.

Reade MC, Young JD (2003) Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis. Br J Anaesth 90:115–118CrossRefPubMed

31.

Diodato MD, Knöferl MW, Schwacha MG, Bland KI, Chaudry IH (2001) Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. Cytokine 14:162–169CrossRefPubMed

32.

Hyde SR, Stith RD, McCallum RE (1990) Mortality and bacteriology of sepsis following cecal ligation and puncture in aged mice. Infect Immun 58:619–624PubMed

33.

Freise H, Brückner UB, Spiegel HU (2001) Animal models of sepsis. J Invest Surg 14:195–212CrossRefPubMed

34.

Albuszies G, Ince C, Radermacher P (2003) How to reconcile clinical criteria and the use of genetically engineered animals in sepsis research: practical aspects of intensive care in mice. In: Vincent JL (ed) Yearbook of intensive care and emergency medicine. Springer, Berlin Heidelberg New York

35.

Huang TT, Raineri I, Eggerding F, Epstein CJ (2002) Transgenic and mutant mice for oxygen free radical studies. Methods Enzymol 349:191–213PubMed

36.

Macarthur H, Couri DM, Wilken GH, Westfall TC, Lechner AJ, Matuschak GM, Chen Z, Salvemini D (2003) Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines. Crit Care Med 31:237–245PubMed

37.

Salvemini D, Cuzzocrea S (2003) Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine. Crit Care Med 31:S29-S38PubMed

38.

Nelson SK, Bose SK, McCord JM (1994) The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart. Free Radic Biol Med 16:195–200CrossRefPubMed

39.

McDonald MC, d'Emmanuele di Villa Bianca R, Wayman NS, Pinto A, Sharpe MA, Cuzzocrea S, Chatterjee PK, Thiemermann C (2003) A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock. Eur J Pharmacol 466:181–189CrossRefPubMed

Title: Antioxidant therapy in sepsis
Authors: Gerd Albuszies
Uwe Bernd Brückner
Publication date: 01-10-2003
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 10/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-1861-5

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Antioxidant therapy in sepsis

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