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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2019

Open Access 01-12-2019 | Antiepileptic Drugs | Research

The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients: a triple blind randomized clinical trial

Authors: Shaghayegh Omrani, Mohammad Taheri, Mir Davood Omrani, Shahram Arsang-Jang, Soudeh Ghafouri-Fard

Published in: Clinical and Translational Medicine | Issue 1/2019

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Abstract

Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. In this triple blind randomized, placebo-controlled parallel group trial of omega-3 FA supplementation, 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) as well as placebo capsules were administered twice a day in 50 patients with refractory seizure during a 16-week period respectively. Seizure frequency and duration were reduced after completion of the treatment in the supplement group. The supplementation resulted in a significant decrease in TNF-α and IL-6 concentrations. Further studies are needed to compare different omega-3 FA compositions and determine the most effective dose and treatment duration as well as the long term benefits of this supplementation.
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Metadata
Title
The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients: a triple blind randomized clinical trial
Authors
Shaghayegh Omrani
Mohammad Taheri
Mir Davood Omrani
Shahram Arsang-Jang
Soudeh Ghafouri-Fard
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2019
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-019-0220-2

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