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World Journal of Pediatrics
Published in: World Journal of Pediatrics 2/2021

01-04-2021 | Antidepressant Drugs | Letter to Editor

Imipramine-precipitated status epilepticus

Author: Ahmed Naguy

Published in: World Journal of Pediatrics | Issue 2/2021

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Excerpt

Frontal lobe epilepsy has a complex and atypical semiology that may masquerade as psychiatric or parasomnias [1]. An electroencephalography (EEG) and sleep lab workup should be an integral part of clinical assessment of these cases to avoid potential pitfalls in management with serious consequences as evidenced in this clinical vignette. By mistaking epilepsy for anxiety, imipramine, a tricyclic antidepressant, known to lower seizure threshold, was prescribed and resulted in status epilepticus. This letter concludes with a brief literature review of antidepressants and seizure risk. …
Literature
1.
Jehi LE. The role of semiology in the work-up of frontal lobe epilepsy: in the eye of the beholder. Epilepsy Curr. 2014;14:194–5.CrossRef
2.
Bourion-Bedes S, Hingray C, Faust H, Vignal JP, Vespignani H, Schwan R, et al. Pitfalls in the diagnosis of new-onset frontal lobe seizures. Epilepsy Behav Case Rep. 2014;2:1–3.CrossRef
3.
Otero S. Psychopathology and psychological adjustment in children and adolescents with epilepsy. World J Pediatr. 2009;5:12–7.CrossRef
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Naguy A, Elbadry H, Salem H. Suicide: a précis! J Fam Med Prim Care. 2020;9:4009–15.CrossRef
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Gorska N, Slupski J, Cubala WJ, Wiglusz MS, Galuszko-Wegielnik M. Antidepressants in epilepsy. NeurolNeurochir Pol. 2018;52:657–61.CrossRef
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Hamid H, Kanner AM. Should antidepressant drugs of the selective serotonin reuptake inhibitors family be tested as antiepileptic drugs? Epilepsy Behav. 2013;26:261–5.CrossRef
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Kanner AM. Depression and epilepsy: a new perspective on two closely related disorders. Epilepsy Curr. 2006;6:141–6.CrossRef
Metadata
Title
Imipramine-precipitated status epilepticus
Author
Ahmed Naguy
Publication date
01-04-2021
Publisher
Springer Singapore
Published in
World Journal of Pediatrics / Issue 2/2021
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-020-00409-6

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