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Open Access 01-12-2020 | Antidepressant Drugs | Research article

Prescribing antidepressants and anxiolytic medications to pregnant women: comparing perception of risk of foetal teratogenicity between Australian Obstetricians and Gynaecologists, Speciality Trainees and upskilled General Practitioners

Authors: Summer Williams, George Bruxner, Emma Ballard, Alka Kothari

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

Excerpt

Depression and anxiety are common disorders, however their occurrence during pregnancy has the potential to significantly impact the health and wellbeing of both mother and child [1, 2]. Negative outcomes of mental health disorders in pregnancy include a variety of serious complications. Inadequately treated depression is associated with a substantial risk of maternal, fetal and neonatal morbidity and mortality [3]. In addition to subjective distress, the impact on relationships can be very significant, particularly when attachment to the newborn is disrupted. This may lead to enduring detrimental effects on the child extending into adulthood [4]. Depression also leads to suicide, with it being the second largest cause of indirect maternal mortality in the perinatal period in Australian women [1]. …

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Australian Institute of Health Welfare, Humphrey M, Bonello M, Chughtai A, Macaldowie A, Harris K, Chambers G. Maternal deaths in Australia, 2008–2012. Canberra: ACT: Australian Institute of Health and Welfare; 2015. p. 108.

Csajka C, Jaquet A, Winterfeld U, Meyer Y, Einarson A, Panchaud A. Risk perception by healthcare professionals related to drug use during pregnancy: a Swiss survey. Swiss Med Wkly. 2014;144:w13936.PubMed

Marcus SM, Heringhausen JE. Depression in childbearing women: when depression complicates pregnancy. Prim Care. 2009;36(1):151–65 ix.CrossRef

Bowlby J. The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the fiftieth Maudsley lecture, delivered before the Royal College of psychiatrists, 19 November 1976. Br J Psychiatry. 1977;130:201–10.CrossRef

Einarson A, Selby P, Koren G. Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling. J Psychiatry Neurosci. 2001;26(1):44–8.PubMedPubMedCentral

Sivertz K, Kostaras X. The use of psychotropic medications in pregnancy and lactation. BC Med J. 2005;47(3):135–8.

Mulder E, Davis A, Gawley L, Bowen A, Einarson A. Motherisk rounds: negative impact of non-evidence-based information received by women taking antidepressants during pregnancy from health care providers and others. J Obstet Gynaecol Can. 2012;34(1):66–71.CrossRef

Kothari A, de Laat J, Dulhunty JM, Bruxner G. Perceptions of pregnant women regarding antidepressant and anxiolytic medication use during pregnancy. Australasian Psychiatry. 2019;27(2):117–20.

Cantilino A, Lorenzo L. Paula JDAd, Einarson a: use of psychotropic medications during pregnancy: perception of teratogenic risk among physicians in two Latin American countries. Rev Bras Psiquiatr. 2014;36(2):106–10.CrossRef

10.

Polifka JE, Faustman EM, Neil N. Weighing the risks and the benefits: a call for the empirical assessment of perceived teratogenic risk. Reprod Toxicol. 1997;11(4):633–40.CrossRef

11.

Bonari L, Koren G, Einarson TR, Jasper JD, Taddio A, Einarson A. Use of antidepressants by pregnant women: evaluation of perception of risk, efficacy of evidence based counseling and determinants of decision making. Arch Women’s Mental Health. 2005;8(4):214–20.CrossRef

12.

Bilszta J, Tsuchiya S, Han K, Buist A, Einarson A. Primary care physician’s attitudes and practices regarding antidepressant use during pregnancy: a survey of two countries. Arch Womens Ment Health. 2011;14(1):71–5.CrossRef

13.

Royal Australian and New Zealand College of Obstetricians and Gynaecologists, editor. Mental health care in the perinatal period. Melbourne, Vic: Royal Australian and New Zealand College of Obstetricians and Gynaecologists; 2018.

14.

Mercier RJ, Garrett J, Thorp J, Siega-Riz AM. Pregnancy intention and postpartum depression: secondary data analysis from a prospective cohort. Bjog. 2013;120(9):1116–22.CrossRef

15.

Marcus SM, Flynn HA, Blow FC, Barry KL. Depressive symptoms among pregnant women screened in obstetrics settings. J Women's Health (Larchmt). 2003;12(4):373–80.CrossRef

16.

Kim HG, Mandell M, Crandall C, Kuskowski MA, Dieperink B, Buchberger RL. Antenatal psychiatric illness and adequacy of prenatal care in an ethnically diverse inner-city obstetric population. Arch Womens Ment Health. 2006;9(2):103–7.CrossRef

17.

Ayres A, Chen R, Mackle T, Ballard E, Patterson S, Bruxner G, Kothari A. Engagement with perinatal mental health services: a cross-sectional questionnaire survey. BMC Pregnancy Childbirth. 2019;19(1):170.CrossRef

18.

Blehar MC, Spong C, Grady C, Goldkind SF, Sahin L, Clayton JA. Enrolling pregnant women: issues in clinical research. Womens Health Issues. 2013;23(1):e39–45.CrossRef

19.

RANZCP Abstracts. Aust N Z J Psychiatry. 2018;52(1_suppl):3–156. https://doi.org/10.1177/0004867418764980. PMID: 29690778.

Title: Prescribing antidepressants and anxiolytic medications to pregnant women: comparing perception of risk of foetal teratogenicity between Australian Obstetricians and Gynaecologists, Speciality Trainees and upskilled General Practitioners
Authors: Summer Williams
George Bruxner
Emma Ballard
Alka Kothari
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Antidepressant Drugs
Antidepressant Drugs
Published in: BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-020-03293-0

Keynote webinar | Spotlight on medication adherence

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Prescribing antidepressants and anxiolytic medications to pregnant women: comparing perception of risk of foetal teratogenicity between Australian Obstetricians and Gynaecologists, Speciality Trainees and upskilled General Practitioners

Excerpt

Keynote webinar | Spotlight on medication adherence

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