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02-10-2021 | Antibiotic | Original Article

An evaluation of the clinical utility of C-reactive protein and antibiotic use in patients undergoing major head and neck reconstructive surgery with outcome assessment

Authors: Natalie Archer, Lara Zebic, Natalie Turton, James Higginson, Matthew Idle, Prav Praveen, Timothy Martin, Sat Parmar, Omar Breik

Published in: Oral and Maxillofacial Surgery | Issue 3/2022

Abstract

Purpose

This ambispective observational study aims to evaluate the local utility of peri-operative CRP testing and prophylactic antibiotics in relation to post-operative complications in patients who have undergone major head and neck oncological reconstructive surgery.

Results

A total of 79 patients were identified for inclusion; CRP testing was undertaken within the first 3 days postoperatively in 78/79 cases. Results demonstrated no benefit of extended prophylactic antibiotic use in reducing post-operative infection. Forty-two post-operative complications arose. In the prospective arm, CRP did not influence the decision to commence antibiotic therapy for any of the surgical site infections. Age, diabetes, smoking, or high body mass index (BMI) did not appear to affect the incidence of postoperative infection (p > 0.05). There is no evidence that more than 24 h of antibiotic prophylaxis is indicated for patients undergoing head and neck reconstructive surgery.

Conclusion

Everyone who is involved in peri-operative patient care should be educated regarding the appropriate use of CRP testing, with the implementation of protocols required to standardize CRP testing and prophylactic antibiotic prescription.

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Title: An evaluation of the clinical utility of C-reactive protein and antibiotic use in patients undergoing major head and neck reconstructive surgery with outcome assessment
Authors: Natalie Archer
Lara Zebic
Natalie Turton
James Higginson
Matthew Idle
Prav Praveen
Timothy Martin
Sat Parmar
Omar Breik
Publication date: 02-10-2021
Publisher: Springer Berlin Heidelberg
Keyword: Antibiotic
Published in: Oral and Maxillofacial Surgery / Issue 3/2022
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-021-01001-6

At a glance: The STEP trials

Springer Medicine

An evaluation of the clinical utility of C-reactive protein and antibiotic use in patients undergoing major head and neck reconstructive surgery with outcome assessment

Abstract

Purpose

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Results

Conclusion

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