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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 8/2021

01-11-2021 | Letter to Editor

Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome

Authors: Natasha Moseley, Jovanka King, Ben Van Dort, Simon Williams, Victoria Rodriguez-Casero, Shanti Ramachandran, Sharon Choo, Theresa Cole, Andrew McLean-Tooke

Published in: Journal of Clinical Immunology | Issue 8/2021

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Excerpt

To the Editor …
Appendix
Available only for authorised users
Literature
1.
Park J, Lee K, Jeon B, Ochs H, Lee J, Gee H, et al. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: a systemic review. Autoimmu Rev. 2020; 19:102526.
2.
Gambineri E, Ciullini Mannurita S, Hagin D, Vignoli M, Anover-Sombke S, DeBoer S, et al. Clinical, immunological, and molecular heterogeneity of 173 patients with the phenotype of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Front Immunol. 2018;9:2411.
3.
Van Sonderen A, Petit-Pedrol M, Dalmau J, Titulaer M. The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis. Nat Rev Neurol. 2017;13:290–301.CrossRef
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Nosadini M, Toldo I, Tascini B, Bien C, Parmeggiani L, De Gaspari P, et al. LGI1 and CASPR2 autoimmunity in children: systemic literature review and report of a young girl with Morvan syndrome. J Neuroimmunol. 2019;335:577008.
5.
Surana S, Kumar R, Pitt M, Hafner P, McLellan A, Davidson J, et al. Acquired neuromyotonia in children with CASPR2 and LGI1 antibodies. Dev Med Child Neurol. 2019;61:1344–7.CrossRef
6.
Jamee M, Zaki-Dizaji M, Lo B, Abolhassani H, Aghamahdi F, Mosavian M, et al. Clinical, Immunological, and genetic features in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-like syndrome. J Allergy Clin Immunol Pract. 2020;8:2747–60.CrossRef
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Sage PT, Sharpe AH. T follicular regulatory cells in the regulation of B cell responses. Trends Immunol. 2015;36:410–8.CrossRef
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Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, et al. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood. 2013;121:1595–603.CrossRef
9.
Barzaghi F, Amaya Hernandez LC, Neven B, Ricci S, Kucuk ZY, Bleesing JJ, et al. Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: an international multicenter retrospective study. J Allergy Clin Immunol. 2018; 141:1036–49 e5.
Metadata
Title
Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome
Authors
Natasha Moseley
Jovanka King
Ben Van Dort
Simon Williams
Victoria Rodriguez-Casero
Shanti Ramachandran
Sharon Choo
Theresa Cole
Andrew McLean-Tooke
Publication date
01-11-2021
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 8/2021
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-021-01128-x

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