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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2004

01-04-2004 | Commentary

Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis

Authors: Hani S El-Gabalawy, John A Wilkins

Published in: Arthritis Research & Therapy | Issue 2/2004

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Abstract

Anti-Sa antibodies are detected in the serum of 20–47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. The Sa antigen has previously been shown to be present in synovium. This, along with the demonstration of citrullinated proteins in rheumatoid synovium, suggests that anti-Sa antibodies may play a pathogenetic role in the initiation and/or persistence of rheumatoid synovitis.
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Metadata
Title
Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis
Authors
Hani S El-Gabalawy
John A Wilkins
Publication date
01-04-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1171

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