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01-12-2019 | Anti-NMDA Receptor Encephalitis | Understanding the Disease

Understanding auto-immune encephalitis in the ICU

Authors: R. Sonneville, A. Venkatesan, J. Honnorat

Published in: Intensive Care Medicine | Issue 12/2019

Excerpt

Encephalitis is a severe neurological syndrome that presents as rapidly progressive encephalopathy caused by brain inflammation, with varying combinations of fever, focal central nervous system (CNS) findings, new-onset seizures, cerebrospinal fluid (CSF) pleocytosis, and neuroimaging and electroencephalography (EEG) abnormalities [1]. It is associated with a multitude of etiologies, including viral infections [2], but in recent years, an increasing number of autoimmune encephalitides (AE) characterized by specific autoantibodies has been recognized [3]. Intensivists should be aware of AE and associated complications because patients frequently necessitate ICU care, specific therapy during several weeks, and because a favorable outcome is observed in most cases. …

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Title: Understanding auto-immune encephalitis in the ICU
Authors: R. Sonneville
A. Venkatesan
J. Honnorat
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Anti-NMDA Receptor Encephalitis
Electroencephalography
Encephalitis
Herpes Simplex Encephalitis
Published in: Intensive Care Medicine / Issue 12/2019
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05773-0

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