Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Inflammation
Published in: Inflammation 4/2016

01-08-2016 | ORIGINAL ARTICLE

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

Authors: Élica Renata Soares da Silva, Gustavo Ruivo Salmazzo, Jucicléia da Silva Arrigo, Rodrigo Juliano Oliveira, Candida Aparecida Leite Kassuya, Cláudia Andréa Lima Cardoso

Published in: Inflammation | Issue 4/2016

Login to get access

Abstract

Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.
Literature
1.
Wilson, P.G., M.M. O’Brien, P.A. Gadek, and C.J. Quinn. 2001. Myrtaceae revised: a reassessment of intrafamilial groups. American Journal of Botany 88: 2012–2025.
2.
3.
Ferreira, L.C., A.G. Guimarães, C.A. Paula, M.C.P. Michel, R.G. Guimarães, S.A. Rezende, J.D. Souza-Filho, and D.A.S. Guimarães. 2013. Anti-inflammatory and antinociceptive activities of Campomanesia adamantium. Journal of Ethnopharmacology 145: 100–108.CrossRefPubMed
4.
Michel, M.C.P., A.G. Guimarães, C.A. Paula, S.A. Rezende, M.E.G. Sobral, and D.A.S. Guimarães. 2013. Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo. Revista Brasileira Farmacognosia 23: 927–936. doi:10.​1590/​S0102-695X201300060001​0.CrossRef
5.
De Souza, J.C., A.C. Piccinelli, D.F. Aquino, V.V. De Souza, W.O. Schmitz, G.K. Traesel, C.A.L. Cardoso, C.A. Kassuya, and A.C. Arena. 2014. Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks. Nutritional Neuroscience 0(0): 1–9. doi:10.​1179/​1476830514Y.​0000000145.
6.
Trojan-Rodrigues, M., T.L.S. Alves, and G.L.G. Soares. 2012. Plants used as antidiabetics in popular medicine in Rio Grande do Sul, Southern Brazil, Ritter, M.R. Journal of Ethnopharmacology 139: 155–163.CrossRefPubMed
7.
Biavatti, M.W., C. Farias, F. Curtius, L.M. Brasil, S. Hort, L. Schuster, S.N. Leite, and S.R.T. Prado. 2004. Preliminary studies on Campomanesia xanthocarpa (Berg.) and Cuphea carthagenensis (Jacq.) J. F. Macbr. Aqueous extract: weight control and biochemical parameters. Journal of Ethnopharmacology 93(2–3): 385–389.CrossRefPubMed
8.
Dickel, M.L., S.M.K. Rates, and M.R. Ritter. 2007. Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil. Journal of Ethnopharmacology 109: 60–71.CrossRefPubMed
9.
Correa, M.P. 1926. Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Vol I. Rio de Janeiro: Imprensa Nacional. 747pp.
10.
Klafke, J.Z., M.A. Silva, T.F. Panigas, K.C. Belli, M.F. Oliveira, M.M. Barichello, F.K. Rigo, M.F. Rossato, A.R.S. Santos, M.G. Pizzolatti, J. Ferreira, and P.R.N. Viecili. 2010. Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients. Journal of Ethnopharmacology 127(2): 299–305.CrossRefPubMed
11.
Viecili, P.R.N., D.O. Borges, K. Kirsten, J. Malheiros, E. Viecili, R.D. Melo, G. Trevisan, M.A. Silva, G.V. Bochi, R.N. Moresco, and J.Z. Klafke. 2014. Effects of Campomanesia xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals. Atherosclerosis 234: 85–92.CrossRefPubMed
12.
Klafke, J. Z., Silva, M. A., Rossato, M. F., Trevisan,G., Walker, C. I. B., Leal, C. A. M., Borges, D. O., Schetinger, M. R. C., Moresco, R. N., Duarte, M. M. M. F., Santos, A. R. S., Viecili, P. R. N., Ferreira, J. 2012. Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine 954748.
13.
Santos, M.S., O.G. Miguel, C.L.O. Petkowicz, and L.M.B. Cândido. 2012. Antioxidant and fatty acid profile of gabiroba seed (Campomanesisa Xanthocarpa Berg). Food Science and Technology 32(2): 234–238.
14.
Vinagre, A.P.S., A.D.S.R.O. Rônnau, S.F. Pereira, L.U. Silveira, E.F. Wiilland, and E.S. Suyenaga. 2010. Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction. Brazilian Journal of Pharmaceutical Sciences 46(2): 169–177.
15.
Markman, B.E.O., E.M. Bacchi, and E.T.M. Kato. 2004. Antiulcerogenic effects of Campomanesia xanthocarpa. Journal of Ethnopharmacology 94(1): 55–57.CrossRefPubMed
16.
Cavalcanti, Y.W., Ana L.A.L. Pérez, G.D.R. Xavier, L.F.D. Almeida, and W.W.N. Padilha. 2012. Atividade Antifúngica de Extratos Vegetais Brasileiros sobre Cepas de Candida. Revista Brasileira de Ciências da Saúde 16(1): 43–48. doi:10.​4034/​RBCS.​2012.​16.​01.​07.CrossRef
17.
Pastori, T., F.C. Flores, A.A. Boligon, M.L. Athayde, C.B. Silva, T.S. Canto-Dorow, and S.B. Tedesco. 2013. Genotoxic effects of Campomanesia xanthocarpa extracts on Allium cepa vegetal system. Pharmaceutical Biology 51(10): 1249–1255. doi:10.​3109/​13880209.​2013.​786097.CrossRefPubMed
18.
Auharek, S.A., M.C. Vieira, C.A.L. Cardoso, R.J. Oliveira, and A.L. Cunha-Laura. 2013. Reproductive toxicity of Campomanesia xanthocarpa (Berg.) in female Wistar rats. Journal of Ethnopharmacology 148: 341–343.CrossRefPubMed
19.
20.
Lin, J.Y., and C.Y. Tang. 2007. Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chemistry 101: 140–147.CrossRef
21.
Djeridane, A., M. Yousfi, B. Nadjemi, D. Boutassouna, P. Stocker, and N. Vidal. 2006. Antioxidant activity of some algerian medicinal plants extracts containing phenolic compounds. Food Chemistry 97: 654–660.CrossRef
22.
Broadhurst, R.B., and W.T. Jones. 1978. Analysis of condensed tannins using acidified vanillin. Journal of the Science of Food and Agriculture 29: 788–794.CrossRef
23.
Agostini-Costa, T.S., D.S. Garruti, L. Lima, S. Freire, F.A.P. Abreu, and T. Feitosa. 1999. Avaliação de metodologias para determinação de taninos no suco de caju. Boletim Centro de Pesquisa de Processamento de Alimentos 17: 167–176.
24.
25.
Resurreccion-Magno, M.H.C., I.M. Villasenor, N. Harada, and K. Monde. 2005. Antihyperglycaemic flavonoids fromSyzygium samarangense(Blume) merr. and Perry. Phytotherapy Research 19(3): 246–251.CrossRefPubMed
26.
Mustafa, K.A., N.B. Perry, and R.T. Weavers. 2005. Lipophilic C-methylflavonoides with no B-ring oxigenation in Metrosideros species (Myrtaceae). Biochemical Systematics and Ecology 33(10): 1049–1059.CrossRef
27.
Agrawal P. K. 1989. Carbon-13 NMR of Flavonoids. Elsevier Science, Amsterdam. p. 564. ISBN 0-444-87449-6
28.
Kassuya, C.A., A. Cremoneze, L.F. Barros, A.S. Simas, F.R. Lapa, R. Mello-Silva, M.E. Stefanello, and A.R. Zampronio. 2009. Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). Journal of Ethnopharmacology 124: 369–376.CrossRefPubMed
29.
Santos, J.A., A. Arruda, M.A. Silva, C.A.L. Cardoso, M.C. Vieira, C.A.L. Kassuya, and A.C. Arena. 2012. Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats. Journal of Ethnopharmacology 144: 802–805.CrossRefPubMed
30.
Ramos, D.D., C.A.L. Cardoso, and N.T. Yamamoto. 2007. Avaliação do potencial citotóxico e atividade antioxidante em Campomanesia adamantium (Cambess.) O. Berg. (Myrtaceae). Brazilian Journal of Bioscienses 5(S2): 774–776.
31.
Coutinho, I.D., R.G. Coelho, V.M.F. Kataoka, N.K. Honda, J.R.M. Silva, W. Vilegas, and C.A.L. Cardoso. 2008. Determination of phenolic compounds and evaluation of antioxidant capacity of Campomanesia adamantium leaves. Ecletica Quimica 33(4): 53–60.CrossRef
32.
Pavan, F.R., C.Q.F. Leite, R.G. Coelho, I.D. Coutinho, N.K. Honda, C.A.L. Cardoso, W. Vilegas, S.R. Leite, and A. De. 2009. Evaluation of anti- Mycobacterium tuberculosis activity of Campomanesia adamantium (MYRTACEAE). Quimica Nova 32(5): 1222–1226.CrossRef
33.
Cardoso, C.A.L., G.R. Salmazzo, N.K. Honda, C.B. Prates, C. Vieira Mdo, and R.G. Coelho. 2010. Antimicrobial activity of the extracts and fractions of hexanic fruits of Campomanesia species (Myrtaceae). Journal of Medicinal Food 13(5): 1273–1276.CrossRefPubMed
34.
Kataoka, V. M. F., Cardoso, C. A. L. 2013. Avaliação do perfil cromatográfico obtidos por CLAE-DAD e da atividade antioxidante das folhas de espécies Campomanesia sessiliflora (O. Berg) Mattos e Campomanesia xanthocarpa O. Berg. Revista Brasileira de Plantas Medicinais 15(1): 121–129. ISSN:1678–7064. doi:10.​1590/​S0100-4042200900050002​6.
35.
Santos, M.S., J.J. Lima, C.L.O. Petkowicz, and L.M.B. Candido. 2013. Chemical characterization and evaluation of the antioxidant potential of gabiroba jam (Campomanesia xanthocarpaBerg). Acta Scientiarum Agronomy 35(1): 73–82.
36.
Coutinho, I.D., V.M.F. Kataoka, N.K. Honda, R.G. Coelho, M.C. Vieira, and C.A.L. Cardoso. 2010. Influência da variação sazonal nos teores de flavonóides e atividade antioxidante das folhas de Campomanesia adamantium (Cambess.) O. Berg, Myrtaceae. Revista Brasileira de Farmacognosia 20(3): 322–327.CrossRef
37.
Oliveira, A.M., L.M. Conserva, J.N.S. Ferro, F.A. Brito, R.P.L. Lemos, and E. Barreto. 2013. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. International Journal of Molecular Sciences 13(2): 1598–1611. doi:10.​3390/​ijms13021598.
38.
Barros, F.E.V., M.G.T. Sousa, J.L. Costa, R.S.G. Olea, S.M.F. Freire, A.C.R. Borges, and M.O.R. Borges. 2004. Avaliação das atividades analgésica e antinflamatória do extrato metanólico de Calotropis procera R. BR. (ciúme). Infarma Ciências Farmacêuticas 16(9): 60–64.
39.
40.
Kassuya, C.A.L., A. Silvestre, O.M. Lima Junior, D.M. Marotta, V.L.G. Rehder, and J.B. Calixto. 2006. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus evidence for interaction with platelet activating factor receptor. European Journal of Pharmacology 546: 182–188.CrossRefPubMed
41.
42.
Di Rosa, M., J.P. Giroud, and D.A. Willoughby. 1971. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. Journal of Pathology 104: 15–44.CrossRefPubMed
Metadata
Title
Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg
Authors
Élica Renata Soares da Silva
Gustavo Ruivo Salmazzo
Jucicléia da Silva Arrigo
Rodrigo Juliano Oliveira
Candida Aparecida Leite Kassuya
Cláudia Andréa Lima Cardoso
Publication date
01-08-2016
Publisher
Springer US
Published in
Inflammation / Issue 4/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-016-0378-3

Other articles of this Issue 4/2016

Inflammation 4/2016 Go to the issue

ORIGINAL ARTICLE

Synergistic Effects of Electroacupuncture and Mesenchymal Stem Cells on Intestinal Ischemia/Reperfusion Injury in Rats

ORIGINAL ARTICLE

Lipopolysaccharide-Activated Leukocytes Enhance Thymic Stromal Lymphopoietin Production in a Mouse Air-Pouch-Type Inflammation Model

ORIGINAL ARTICLE

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

ORIGINAL ARTICLE

Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results

ORIGINAL ARTICLE

Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing

ORIGINAL ARTICLE

Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits