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Inflammation
Published in: Inflammation 4/2012

01-08-2012

Anti-inflammatory Effect of Piperine in Adjuvant-Induced Arthritic Rats—a Biochemical Approach

Authors: Vachana Murunikkara, Samuel Joshua Pragasam, Geema Kodandaraman, Evan Prince Sabina, MahaboobKhan Rasool

Published in: Inflammation | Issue 4/2012

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Abstract

The present study was undertaken to investigate the anti-inflammatory effect of piperine against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis and compared it with that of the non-steroidal anti-inflammatory drug indomethacin. Administration of heat-killed Mycobacterium tuberculosis (0. 1 ml) intradermally into the right hind paw of rats resulted in increased paw volume, lysosomal enzymes, glycoproteins and tissue marker enzymes and decreased body weight. However, these changes were reverted to near normal levels upon piperine (30 mg/kg body weight, i.p.) treatment. Histopathological analysis of joints also revealed that synovial hyperplasia and mononuclear infiltration observed in arthritic rats were alleviated by piperine. Thus, the present study clearly indicated that piperine possesses promising anti-inflammatory effect against adjuvant-induced arthritis by suppressing inflammation and cartilage destruction.
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Metadata
Title
Anti-inflammatory Effect of Piperine in Adjuvant-Induced Arthritic Rats—a Biochemical Approach
Authors
Vachana Murunikkara
Samuel Joshua Pragasam
Geema Kodandaraman
Evan Prince Sabina
MahaboobKhan Rasool
Publication date
01-08-2012
Publisher
Springer US
Published in
Inflammation / Issue 4/2012
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-012-9448-3

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